Histone deacetylase Sir2 promotes the systemic
Candida albicans
infection by facilitating its immune escape via remodeling the cell wall and maintaining the metabolic activity
Chen Yang,
Guanglin Li,
Qiyue Zhang
et al.
Abstract:Histone deacetylation affects
Candida albicans
(
C. albicans
) pathogenicity by modulating virulence factor expression and DNA damage. The histone deacetylase Sir2 is associated with
C. albicans
plasticity and maintains genome stability to help
C. albicans
adapt to various environmental niches. However, whether Sir2-mediated chromatin modification affects
C. albicans
virul… Show more
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