Histone Deacetylase Inhibitors Induced Differentiation and Accelerated Mineralization of Pulp-derived Cells

The Role of SIRT1 on Angiogenic and Odontogenic Potential in Human Dental Pulp Cells

“…It was recently reported that histone deacetylase inhibitors could positively affect cell proliferation, cell differentiation, and the cell cycle, leading to accelerated mineralization events in dental pulp-derived cells (20). However, the molecular control mechanism on HDPCs differentiate into were transfected with control vector and 250 pmol SIRT-1 siRNA for 24 hours and exposed to OM for 7 days.…”

Effects of histone deacetylase inhibitors on regenerative cell responses in human dental pulp cells

“…, Marks , Duncan et al . ). These apparently contradictory results indicate that in certain cell environments, concentrations of HDACi may play pivotal roles in regulating cell growth.…”

Bone Density and Dental External Apical Root Resorption

“…[42] More closely connected to dental development, however, altered pulp cell differentiation was observed with accelerated mineralization when two HDAC inhibitors were administered. [43] More importantly, recent evidence, which surprisingly contrasts with these results, has contributed the insights that HDAC5 negatively regulates sclerostin levels secreted by osteocytes in vitro and in vivo , and that sclerostin is an inhibitor of bone formation by osteoblasts. [44] Therefore, HDAC5 itself may indirectly be an enhancer of alveolar bone mineral density.…”