Histone deacetylase inhibitor induces the odontogenic differentiation in human dental pulp cells: comparison of trichostatin a (TSA) and suberoylanilide hydroxamic acid (SAHA)
Abstract:Human dental pulp cells (hDPCs) have shown their plasticity to differentiate into odontoblast-like cell lineages under the treatment of two-members of hydroxamates HDAC inhibitors (HDACis), Trichostatin A (TSA) and Suberoylanilide hydroxamic acid (SAHA). However, a comparison of the potency for stimulating odontoblast-like differentiation and mineralization process among these two HDACis has not been reported. Therefore, we aimed to confirm and compare the stimulatory effect of TSA and SAHA in inducing odontob… Show more
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