Histone deacetylase inhibitor abexinostat (S78454/PCI-24781) as a successful approach in a case of refractory peripheral angio-immunoblastic T-cell lymphoma, as a bridge to reduced intensity conditioning haplo-identical allogenic stem cell transplant

Biology and Molecular Pathogenesis of Mature T-Cell Lymphomas

“…Two widely used hypomethylating agents are decitabine (5-aza-2 0 -deoxycytidine) and 5-aza-cytidine, cytidine antimetabolite analogs that incorporate into DNA and inhibit DNA methyltransferases, resulting in hypomethyla-tion of DNA. Initial case reports demonstrated a positive outcome for AITL patients treated with 5-aza-cytidine (Cheminant et al 2015;Saillard et al 2016) and a clinical trial with relapsed PTCL patients resulted in 53% overall response rate (ORR) and 75% ORR when only AITL patients were analyzed (Saillard et al 2016).…”