Histone Deacetylase AtSRT1 Links Metabolic Flux and Stress Response in Arabidopsis

Liu, Xiaoyun; Wei, Wei; Zhu, Wenjun; Su, Lufang; Xiong, Zeyang; Zhou, Man; Zheng, Yu; Zhou, Dao‐Xiu

doi:10.1016/j.molp.2017.10.010

Cited by 68 publications

(66 citation statements)

References 45 publications

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“…One possibility would be that HDA15 stabilizes HFR1 by regulating lysine acetylation of HFR1 which is however not yet demonstrated. Previous data have shown that lysine acetylation promotes ubiquitination and proteolysis of a target protein and deacetylation by an HDAC could stabilize the protein in Arabidopsis (Liu et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Arabidopsis histone deacetylase HDA15 directly represses plant response to elevated ambient temperature

et al. 2019

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Elevated ambient temperatures affect plant growth and substantially impact biomass and crop yield. Recent results have indicated that chromatin remodelling is critical in plant thermal responses but how histone modification dynamics affects plant thermal response has not been clearly demonstarted. Here we show that Arabidopsis histone deacetylase genes HDA9, HDA15 and HDA19 play distinct roles in plant response to elevated ambient temperature. hda9 and hda19 mutants showed a warm-temperature-insensitive phenotype at 27°C, whereas hda15 plants displayed a constitutive warm-temperature-induced phenotype at 20°C and an enhanced thermal response at 27°C. The hda19 mutation led to upregulation of genes mostly related to stress response at both 20 and 27°C. The hda15 mutation resulted in upregulation of many warm temperature-responsive as well as metabolic genes at 20 and 27°C, while hda9 led to differential expression of a large number of genes at 20°C and impaired induction of warm-temperature-responsive genes at 27°C. HDA15 is associated with thermosensory mark genes at 20°C and that the association is decreased after shifting to 27°C, indicating that HDA15 is a direct repressor of plant thermal-responsive genes at normal temperature. In addition, as hda9, the hda15 mutation also led to upregulation of many metabolic genes and accumulation of primary metabolites. Furthermore, we show that HDA15 interacts with the transcription factor HFR1 (long Hypocotyl in Far Red1) to cooperatively repress warm-temperature response. Our study demonstrates that the histone deacetylases target to different sets of genes and play distinct roles in plant response to elevated ambient temperature.

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Section: Discussionmentioning

confidence: 97%

Arabidopsis histone deacetylase HDA15 directly represses plant response to elevated ambient temperature

et al. 2019

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“…More than one SRT1 gene copy was found only in Fagaceae genomes (Fig 7). SRT1 is required for transposon repression and to regulate the expression of genes involved in plant stress-response and programmed cell death [101,102]. Unfortunately, it was not possible to obtain any clue about QsSRT1 functional divergence since only QsSRT1-like3 was significantly expressed in the Q. suber tissues analyzed in this work (more expressed in last stages of male flower development, in embryos and in well-watered roots) (Fig 8, Table S3).…”

Section: Discussionmentioning

confidence: 89%

Genome-Wide Identification of Epigenetic Regulators inQuercus suber

Silva

Sobral

Magalhães

et al. 2020

Preprint

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Modifications of DNA and histones, including methylation and acetylation, are critical for the epigenetic regulation of gene expression during plant development, particularly during environmental adaptation processes. However, information on the enzymes catalyzing all these modifications in perennial trees, such as Quercus suber, is still not available. In this study, several epigenetic modifier proteins, including eight DNA methyltransferases (DNA Mtases), three DNA demethylases (DDMEs) and ninety-one histone modifiers including thirty-five histone methyltransferases (HMTs), twenty-six histone demethylases (HDMTs), eight histone acetyltransferases (HATs) and twenty-two histone acetylases (HDACs) were identified in Q. suber. Phylogenetic analyses of the DNA and histone modifier proteins were performed using several plant species homologs, enabling the classification of the Q. suber proteins. Additional in silico analysis showed that some Q. suber DNA Mtases, DMEs and histone modifiers have the typical domains found in the plant model Arabidopsis, which might suggest a conserved functional role. A link between the expression levels of each gene in different Q. suber tissues (buds, flowers, acorns, embryos, cork and roots) with the functions already known for their closest homologs in other species was also established. Therefore, the data generated here are important for future studies exploring the role of epigenetic regulators in this economically important species.

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“…Arabidopsis Has a Complex NAD Salvage System Linked to NA Conjugation NAM is known to be generated in almost all living organisms (prokaryotic and eukaryotic) by NAD-consuming enzymes, such as PARP and Sir2 (Vanderauwera et al, 2007;Gazzaniga et al, 2009;Liu et al, 2017;Yoshino et al, 2018). In mammals, NAM can be converted to NMN by nicotinamide phosphoribosyltransferase and then to NAD (Rongvaux et al, 2002), and NAM can also be metabolized to N-methylnicotinamide by nicotinamide N-methyltransferase (NNMT) (Aksoy et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

MeNA, Controlled by Reversible Methylation of Nicotinate, Is an NAD Precursor that Undergoes Long-Distance Transport in Arabidopsis

Zhang

Liu

et al. 2018

Molecular Plant

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Nicotinamide adenine dinucleotide (NAD) biosynthesis, including synthesis from aspartate via the de novo pathway and from nicotinate (NA) via the Preiss-Handler pathway, is conserved in land plants. Diverse species of NA conjugates, which are mainly involved in NA detoxification, were also found in all tested land plants. Among these conjugates, MeNA (NA methyl ester) has been widely detected in angiosperm plants, although its physiological function and the underlying mechanism for its production in planta remain largely unknown. Here, we show that MeNA is an NAD precursor undergoing more efficient long-distance transport between organs than NA and nicotinamide in Arabidopsis. We found that Arabidopsis has one methyltransferase (designated AtNaMT1) capable of catalyzing carboxyl methylation of NA to yield MeNA and one methyl esterase (MES2) predominantly hydrolyzing MeNA back to NA. We further uncovered that the transfer of [C]MeNA from the root to leaf was significantly increased in both MES2 knockdown and NaMT1-overexpressing lines, suggesting that both NaMT1 and MES2 fine-tune the long-distance transport of MeNA, which is ultimately utilized for NAD production. Abiotic stress (salt, abscisic acid, and mannitol) treatments, which are known to exacerbate NAD degradation, induce the expression of NaMT1 but suppress MES2 expression, suggesting that MeNA may play a role in stress adaption. Collectively, our study indicates that reversible methylation of NA controls the biosynthesis of MeNA in Arabidopsis, which presumably functions as a detoxification form of free NA for efficient long-distance transport and eventually NAD production especially under abiotic stress, providing new insights into the relationship between NAD biosynthesis and NA conjugation in plants.

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Histone Deacetylase AtSRT1 Links Metabolic Flux and Stress Response in Arabidopsis

Cited by 68 publications

References 45 publications

Arabidopsis histone deacetylase HDA15 directly represses plant response to elevated ambient temperature

Arabidopsis histone deacetylase HDA15 directly represses plant response to elevated ambient temperature

Genome-Wide Identification of Epigenetic Regulators inQuercus suber

MeNA, Controlled by Reversible Methylation of Nicotinate, Is an NAD Precursor that Undergoes Long-Distance Transport in Arabidopsis

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