Histone deacetylase 8 promotes innate antiviral immunity through deacetylation of RIG-I
Huijun Zhang,
Tingli Liu,
Xinhua Liu
et al.
Abstract:Histone deacetylates family proteins have been studied for their function in regulating viral replication by deacetylating non-histone proteins. RIG-I (Retinoic acid-inducible gene I) is a critical protein in RNA virus-induced innate antiviral signaling pathways. Our previous research showed that HDAC8 (histone deacetylase 8) involved in innate antiviral immune response, but the underlying mechanism during virus infection is still unclear. In this study, we showed that HDAC8 was involved in the regulation of v… Show more
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