Histone chaperones: Variety and functions

Валиева, М. Е.; Feofanov, Аlexey V.; Studitsky, Vasily M.

doi:10.3103/s0096392516030123

Cited by 4 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HCs are defined as protein molecules responsible for histone metabolism. HCs play an important role in maintaining the chromatin dynamics of the cell by maintaining, transporting, recruiting and replacing the histones [28]. HCs can recruit the histone molecules at nucleosome independently or in association with other HCs [29].…”

Section: Epigenetics Of Histonementioning

confidence: 99%

See 1 more Smart Citation

A three layered histone epigenetics in breast cancer metastasis

2020

View full text Add to dashboard Cite

Thanks to the advancement in science and technology and a significant number of cancer research programs being carried out throughout the world, the prevention, prognosis and treatment of breast cancer are improving with a positive and steady pace. However, a stern thoughtful attention is required for the metastatic breast cancer casesthe deadliest of all types of breast cancer, with a character of relapse even when treated. In an effort to explore the less travelled avenues, we summarize here studies underlying the aspects of histone epigenetics in breast cancer metastasis. Authoritative reviews on breast cancer epigenetics are already available; however, there is an urgent need to focus on the epigenetics involved in metastatic character of this cancer. Here we put forward a comprehensive review on how different layers of histone epigenetics comprising of histone chaperones, histone variants and histone modifications interplay to create breast cancer metastasis landscape. Finally, we propose a hypothesis of integrating histone-epigenetic factors as biomarkers that encompass different breast cancer subtypes and hence could be exploited as a target of larger population.

show abstract

Section: Epigenetics Of Histonementioning

confidence: 99%

“…HCs can recruit the histone molecules at nucleosome independently or in association with other HCs [29]. Functionally histone chaperones have been implicated in replication, repair and in regulation of transcription as well [28].…”

Section: Epigenetics Of Histonementioning

confidence: 99%

A three layered histone epigenetics in breast cancer metastasis

2020

View full text Add to dashboard Cite

show abstract

“…Furthermore, HCs control the replacement of canonical histones for histone variants where required, in some cases forming histone buffers. Histone buffers store unused histones until needed, and will then deposit them back onto chromatin (Luger, 2006;Keck and Pemberton, 2011;Valieva et al, 2016). Many chaperones have redundant mechanisms to compensate for the loss of function if one chaperone is missing or defective, therefore stressing their importance in the genome Selth et al, 2009).…”

Section: Histone Chaperones (Hc)mentioning

confidence: 99%

Novel Insights into Nuclear Localization of Proteins Crucial for Chromatin Assembly Metabolism in Saccharomyces cerevisiae

Dannah

2024

Preprint

View full text Add to dashboard Cite

Proper chromatin assembly is critical for maintaining genetic integrity, accurate DNA repair as well as gene expression. These processes are fundamental in eukaryotic cells, and studying them in the powerful budding yeast genetic model allows us to uncover novel mechanisms in the regulation of chromatin assembly and dynamics. Chromatin is assembled by replication-independent or replication-coupled pathways, where histone chaperones (HCs) and modifying enzymes (such as HATs) are key factors in regulating these mechanisms. Alterations in these factors have been implicated in cancer and multiple human diseases. Therefore, the goal is to investigate the involvement of histone chaperones and HATs in the regulation of chromatin assembly. One interesting aspect of my research is the evolutionarily conserved histone H3-H4-specific chaperone Hif1. Hif1, as well as its human homolog NASP, is involved in a wide array of chromatin-related processes, including histone H3-H4 transport, chromatin assembly and DNA repair. This research elucidated several functional aspects of Hif1. I revealed that an acidic region interpreting the second TPR domain of Hif1 is essential for Hif1 physical interactions with Hat2 (HAT-B complex), H4 (Histone H3-H4), as well as Asf1. Moreover, this study was the first to demonstrate that the nuclear localization of Hif1 is regulated by a classical nuclear localization sequence (cNLS) located at its C-terminus. Another aspect of my research is to investigate the role of putative cNLSs in the complex interplay between Rtt109, Vps75 and Asf1 in H3K56ac in S cerevisiae. In yeast, H3K56ac plays a key role in DNA replication and genome stability. Therefore, I began to investigate the fungus- specific HAT Rtt109 that is required for the Asf1-dependant acetylation of K56 on histone H3. Here, I showed that the putative cNLS of Rtt109 is indeed a functional cNLS. I further provided evidence that Rtt109 is imported to the nucleus through its cNLS in a redundant manner with Vps75. Furthermore, I identified a cNLS within the acidic C-terminus of Asf1 in S. cerevisiae, which has a critical role in Asf1 nuclear localization. My work demonstrates that this cNLS of Asf1 is also required for full H3K56 acetylation. Additionally, this research expounds on how the cNLSs of Hif1, Rtt109 and Asf1 can mediate their nuclear import pathway. I specifically showed that Kap123 is partially involved in Rtt109 nuclear localization and import, conversely, Hif1 and Asf1 might use Kap123 as a secondary transporter. Finally, I provide evidence that Kap95 might be one major importin that plays an important role in Hif1, Asf1 and Rtt109 nuclear import pathway. To my knowledge, this study is the first to reveal the presence of functional cNLS motifs within Hif1, Asf1 and Rtt109. This novel finding may provide insights into learning about analogous pathways in human cells.

show abstract

Translational epigenetics in neurodegenerative diseases

Tabassum

Parvez

2021

Epigenetics and Metabolomics

View full text Add to dashboard Cite

Histone chaperones: Variety and functions

Cited by 4 publications

References 43 publications

A three layered histone epigenetics in breast cancer metastasis

A three layered histone epigenetics in breast cancer metastasis

Novel Insights into Nuclear Localization of Proteins Crucial for Chromatin Assembly Metabolism in Saccharomyces cerevisiae

Translational epigenetics in neurodegenerative diseases

Contact Info

Product

Resources

About