Histone acetyltransferease p300 modulates TIM4 expression in dendritic cells

Yang, Bo; Li, Lin-Jing; Xu, Lingzhi; Liu, Jiang‐Qi; Zhang, Huanping; Geng, Xinyu; Liu, Zhigang; Yang, Ping‐Chang

doi:10.1038/srep21336

Cited by 17 publications

(15 citation statements)

References 22 publications

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“…Although we found this phenomenon in previous studies, in which we observed that CT increased TIM4 expression to facilitate the development of food allergy in mice1112, while we observed that TIM4 was also associated with the initiation of an allergen-related inflammation in the colon mucosa. We also observed that p300 and STAT6 mediate the microbial product CT-induced TIM4 expression in DCs in a recent study13.…”

Section: Discussionsupporting

confidence: 73%

Induction of colitis in mice with food allergen-specific immune response

Zeng

et al. 2016

Sci Rep

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The pathogenesis of intestinal chronic inflammation is unclear. Food allergy plays an important role in the induction of intestinal inflammation. This study aims to test a hypothesis that food allergy initiates colitis. In this study, BALB/c mice were sensitized to a common food allergen, ovalbumin (OVA) with cholera toxin (CT) as an adjuvant. The colon epithelial barrier function was assessed with Ussing chamber technique. Expression of T cell immunoglobulin mucin domain molecule-4 (TIM4) in dendritic cells was evaluated by flow cytometry, RT-PCR and Western blotting. The results showed that allergen-related colitis was induced in mice as shown by heavy infiltration of inflammatory cells in the colon mucosa, loss of body weight of mice, increases in myeloperoxidase, tumor necrosis factor-α, interleukin-4, OVA-specific IgE in the colon tissue. The colon epithelial barrier function was markedly compromised in colitis group mice, which was mimicked by exposure the colon mucosa to CT in Ussing chamber. High frequency of TIM4+ dendritic cells was detected in the colon mucosa of colitis mice. Exposure of dendritic cells to CT markedly increased the expression of TIM4. We conclude that IBD-like inflammation can be induced in the mouse colon by the food allergen-related immune response.

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Section: Discussionsupporting

confidence: 73%

Induction of colitis in mice with food allergen-specific immune response

Zeng

et al. 2016

Sci Rep

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“…However, the mechanisms governing Tim-4 expression remain largely elusive. Some evidences suggested that the histone acetyltransferase, p300, and STAT6 regulate the expression of Tim-4 in DCs upon stimulation by the cholera toxin (25). Recently, it was found that cigarette smoke extract (CSE) upregulated Tim-4 expression in immature DCs from murine bone marrow, and the upregulation of Tim-4 stimulated by CSE was inhibited by an ERK inhibitor but not by a p38 or JNK inhibitor (26).…”

Section: Introduction To Tim-4mentioning

confidence: 99%

Tim-4 in Health and Disease: Friend or Foe?

Liang

et al. 2020

Front. Immunol.

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T-cell immunoglobulin and mucin domain containing 4 (Tim-4) is a phosphatidylserine receptor and is selectively expressed on antigen presenting cells. Recently, Tim-4 was reported to be expressed on iNKT cells, B1 cells, and tumor cells, suggesting it has multiple biological functions. In this review, we mainly summarize the expression and regulation of Tim-4 in immune cells including T cells, macrophages, dendritic cells, NKT cells, B cells, and mast cells. The expression of Tim-4 in these cells implies that Tim-4 might participate in immune related diseases. Emerging evidence emphasizes a substantial role for Tim-4 in maintaining homeostasis by regulating various immune responses, including viral infection, allergy, autoimmunity, and tumor immunity. Here, we collectively evaluated the role of Tim-4 in health and diseases. This summary will be extremely useful to fully understand the function of Tim-4 in the pathogenesis of immune related diseases, which would provide novel clues for the diagnosis and treatment of diseases.

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“…The data reported above suggest that Gal‐1 may enhance the efficacy of the traditional SIT on allergic responses. To examine this, we developed a food allergy model with OVA and CT (cholera toxin; Sigma‐Aldrich) with the established procedures . From week 5, the sensitized mice were treated with SIT and/or Gal‐1.…”

Section: Resultsmentioning

confidence: 99%