Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis

Garrido, Amanda; Kim, Eun-Jeong; Teijeiro, Ana; Sánchez, Paula Sánchez; Gallo, Rosa; Nair, Ajay; Montoya, Maria Matamala; Perna, Cristian; Vicent, Guillermo P.; Muñoz, Javier; Campos-Olivas, Ramón; Melms, Johannes C.; Izar, Benjamin; Schwabe, Robert F.; Djouder, Nabil

doi:10.1016/j.jhep.2021.12.019

Cited by 26 publications

(12 citation statements)

References 21 publications

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“… 150 Fundamentally, BAs activate farnesoid X receptor (FXR) and G-protein coupled BA receptor 1 (GPBAR1) that both control numerous oncogenic processes, including inflammation, oxidative stress, and the regulation of many cancer-related genes. 150 BAs act through FXR in different cell types and organs, including the gut, 151 hepatocytes, 152 hepatic stellate cells (HSCs) 152 and immune cells. 153 Conversely, a stepwise increase in plasma-conjugated BAs has been observed in the trajectory from healthy control to benign biliary disease, and further to CCA.…”

Section: Deregulation Of Lipid Metabolism In Liver Cancermentioning

confidence: 99%

Lipid alterations in chronic liver disease and liver cancer

2022

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Section: Deregulation Of Lipid Metabolism In Liver Cancermentioning

confidence: 99%

Lipid alterations in chronic liver disease and liver cancer

2022

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“…In addition, scRNAseq has revealed that high expression of FXR contributes to HSC activation and collagen production in cholestatic liver disease. 160 Another important BA receptor is TGR5 (also known as GPBAR1), a surface receptor that has been linked with steatosis and inflammation, which has a direct role in NLRP3 macrophage polarisation in NASH. 161 Furthermore dysregulated BA homeostasis alters the immune cell composition.…”

Section: Endothelial Cells and Their Interactionsmentioning

confidence: 99%

Understanding the cellular interactome of non-alcoholic fatty liver disease

et al. 2022

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“…Interestingly, senescence-associated secretory phenotypes were also observed after secondary unconjugated BAs treatment. Garrido et al (Garrido et al, 2022) showed that the accumulation of bile acids in liver sinusoids, which was resulted from the histone acetylation of the gene encoding Na + -taurocholate co-transporting polypeptide (NTCP), led to the activation of HSCs through FXR and progression of cirrhosis.…”

Section: Metabolism Regulated By Gut Microbiota Has Both Direct and I...mentioning

confidence: 99%

Circadian Rhythms Coordinated With Gut Microbiota Partially Account for Individual Differences in Hepatitis B-Related Cirrhosis

Wang

Rong

Zhao

2022

Front. Cell. Infect. Microbiol.

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Cirrhosis is the end stage of chronic liver diseases like chronic hepatitis B. In China, hepatitis B accounts for around 60% of cases of cirrhosis. So far, clinical and laboratory indexes for the early diagnosis of cirrhosis are far from satisfactory. Nevertheless, there haven’t been specific drugs for cirrhosis. Thus, it is quite necessary to uncover more specific factors which play their roles in cirrhosis and figure out the possible therapeutic targets. Among emerging factors taking part in the initiation and progression of cirrhosis, gut microbiota might be a pivot of systemic factors like metabolism and immune and different organs like gut and liver. Discovery of detailed molecular mechanism in gut microbiota and gut liver axis leads to a more promising prospect of developing new drugs intervening in these pathways. Time-based medication regimen has been proofed to be helpful in hormonotherapy, especially in the use of glucocorticoid. Thus, circadian rhythms, though haven’t been strongly linked to hepatitis B and its complications, are still pivotal to various pathophysiological progresses. Gut microbiota as a potential effective factor of circadian rhythms has also received increasing attentions. Here, our work, restricting cirrhosis to the post-hepatitis B one, is aimed to summarize how circadian rhythms and hepatitis B-related cirrhosis can intersect via gut microbiota, and to throw new insights on the development of new and time-based therapies for hepatitis B-related cirrhosis and other cirrhosis.

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Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis

Cited by 26 publications

References 21 publications

Lipid alterations in chronic liver disease and liver cancer

Lipid alterations in chronic liver disease and liver cancer

Understanding the cellular interactome of non-alcoholic fatty liver disease

Circadian Rhythms Coordinated With Gut Microbiota Partially Account for Individual Differences in Hepatitis B-Related Cirrhosis

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