Histone acetylation in an Alzheimer’s disease cell model promotes homeostatic amyloid-reducing pathways
Daniel C. Xu,
Hanna Sas-Nowosielska,
Greg Donahue
et al.
Abstract:Alzheimer's Disease (AD) is a disorder characterized by cognitive decline, neurodegeneration, and accumulation of amyloid plaques and tau neurofibrillary tangles in the brain. Dysregulation of epigenetic histone modifications may lead to expression of transcriptional programs that play a role either in protecting against disease genesis or in worsening of disease pathology. One such histone modification, acetylation of histone H3 lysine residue 27 (H3K27ac), is primarily localized to genomic enhancer regions a… Show more
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