Histone acetylation and the role of histone deacetylases in normal cyclic endometrium

Gujral, Palak; Mahajan, Vishakha; Lissaman, Abbey C; Ponnampalam, Anna P.

doi:10.1186/s12958-020-00637-5

Cited by 92 publications

(77 citation statements)

References 100 publications

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“…The obtained results indicate the highest levels of HAT and HDAC activity on days 2-10 of the cycle. In human endometrium, increased HAT activity at the early stage of proliferation may be associated with the increased transcriptional activity of genes involved in endometrial regeneration [43,44]. The subsequent decrease in acetylation in the secretory phase was associated with the regression of the corpus luteum and changes in endometrial function related to the absence of pregnancy [43].…”

Section: Discussionmentioning

confidence: 99%

Steroid Receptor Coregulators Can Modulate the Action of Progesterone Receptor during the Estrous Cycle in Cow Endometrium

Rękawiecki

Dobrzyn

Kowalik

2021

Animals

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Nuclear receptor coregulators include coactivators and corepressors which associate with the progesterone receptor (PGR) during its activation. Fluctuations in the transcription levels of their respective genes and subsequent protein production as well as in related activities for histone acetyltransferase (HAT) and histone deacetylase (HDAC) can affect PGR function and thus change the action of progesterone (P4) in bovine endometrium during the estrous cycle. Endometrial tissue on days 2–5, 6–10, 11–16, and 17–20 of the estrous cycle was used for determination of the mRNA expression levels of coactivators P300, CREB, and SRC-1 along with corepressor NCOR-2 using Real-Time PCR, with protein levels by Western blot. Coregulators cellular localizations were assessed by immunohistochemistry whereas the activities of HAT and HDAC by using EIA. The highest levels of mRNA and proteins for all of the investigated coregulators, as well as the highest levels of activity for HAT and HDAC, were detected over days 2–16 of the estrous cycle. All of the tested coregulatory proteins were localized in the nuclei of endometrial cells. This research indicates the important role of coregulators of the PGR receptor in regulating P4 activity in endometrial cells, especially during the pre-implantation period.

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Section: Discussionmentioning

confidence: 99%

Steroid Receptor Coregulators Can Modulate the Action of Progesterone Receptor during the Estrous Cycle in Cow Endometrium

Rękawiecki

Dobrzyn

Kowalik

2021

Animals

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“…On the basis that butyrate is an HDAC inhibitor, studies have speculated that the SCFA induces epigenetic reprogramming [ 43 ]. In line with this concept, bone marrow-derived macrophage (BMDM) polarisation toward an M2 phenotype was induced by butyrate through acetylation of H3K9, which showed to be a histone modification that enhances STAT6 activation [ 49 ]. The question remains whether butyrate can modulate macrophage plasticity.…”

Section: Dietary Approaches For Targeting Macrophage Plasticitymentioning

confidence: 99%

Diet–Microbiota Interplay: An Emerging Player in Macrophage Plasticity and Intestinal Health

O’Mahony

Amamou

Ghosh

2022

IJMS

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Inflammatory bowel diseases (IBD) are chronic disorders of the gastrointestinal tract with an increasing prevalence worldwide. Targeted therapies for IBD are limited by several factors, including the therapeutic ceiling and the high incidence of non-responders or loss-of-response. In order to improve therapeutic efficacy, there is critical need to decipher disease pathogenesis, currently not well understood. Macrophages, innate immune cells that exhibit high plasticity, perpetuate inflammatory signalling in IBD through excessive release of inflammatory mediators. In recent years, pioneering research has revealed the importance of the interplay between macrophages and gut microbiota in maintaining intestinal homeostasis. Particular attention is focusing on microbiota-derived metabolites, believed to possess immunomodulatory properties capable of manipulating macrophage plasticity. Microbiota-derived short-chain fatty acids (SCFAs) and indole compounds, along with dietary sourced omega-3 (ω-3) polyunsaturated fatty acids (PUFA), exert anti-inflammatory effects, attributable to interactions with macrophages. Before we can effectively incorporate these metabolites into IBD therapies, a deeper understanding of microbiota–macrophage interactions at a molecular level is necessary. Therefore, the aim of this review is firstly to detail current knowledge regarding how diet and microbiota-derived metabolites modify macrophage plasticity. Later, we discuss the concept of therapeutic strategies directed at microbiota–macrophage interactions, which could be highly valuable for IBD therapies in the future.

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“…PTM by HATs or HDACs plays an important role in various types of cancers. In EC, the deregulation of HDACs has been reported more than HATs [ 66 ].…”

Section: Mechanisms Of Carcinogenesis and Cancer Progression Involmentioning

confidence: 99%

Targeting Epigenetic Regulators for Endometrial Cancer Therapy: Its Molecular Biology and Potential Clinical Applications

Inoue¹,

Sone²,

Toyohara³

et al. 2021

IJMS

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Endometrial cancer is one of the most frequently diagnosed gynecological malignancies worldwide. However, its prognosis in advanced stages is poor, and there are only few available treatment options when it recurs. Epigenetic changes in gene function, such as DNA methylation, histone modification, and non-coding RNA, have been studied for the last two decades. Epigenetic dysregulation is often reported in the development and progression of various cancers. Recently, epigenetic changes in endometrial cancer have also been discussed. In this review, we give the main points of the role of DNA methylation and histone modification in endometrial cancer, the diagnostic tools to determine these modifications, and inhibitors targeting epigenetic regulators that are currently in preclinical studies and clinical trials.

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Histone acetylation and the role of histone deacetylases in normal cyclic endometrium

Cited by 92 publications

References 100 publications

Steroid Receptor Coregulators Can Modulate the Action of Progesterone Receptor during the Estrous Cycle in Cow Endometrium

Steroid Receptor Coregulators Can Modulate the Action of Progesterone Receptor during the Estrous Cycle in Cow Endometrium

Diet–Microbiota Interplay: An Emerging Player in Macrophage Plasticity and Intestinal Health

Targeting Epigenetic Regulators for Endometrial Cancer Therapy: Its Molecular Biology and Potential Clinical Applications

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