Histone acetylation and chromatin signature in stem cell identity and cancer

Shukla, Vivek; Vaissière, Thomas; Herceg, Zdenko

doi:10.1016/j.mrfmmm.2007.07.012

Cited by 80 publications

(55 citation statements)

References 104 publications

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“…Levels of compaction of chromatin dictate the accessibility of genomic DNA and, together with epigenetic mechanisms such as histone modifications and methylation of DNA at cytosine residues in CpG dinucleotides, will largely confer the unique properties we call 'stemness' and be pivotal in the maintenance of stem cell identity and the subsequent fate of differentiating progeny (reviewed in [73,74]). For example, histone acetylation, mediated by histone acetyltransferases, removes positive charges, thereby reducing the affinity of histones with DNA, and is associated with increased transcription.…”

Section: Epigenetic Modificationsmentioning

confidence: 99%

Attributes of adult stem cells

Alison

Islam

2008

The Journal of Pathology

151

115

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While cultured embryonic stem (ES) cells can be harvested in abundance and appear to be the most versatile of cells for regenerative medicine, adult stem cells also hold promise, but the identity and subsequent isolation of these comparatively rare cells remains problematic in most tissues, perhaps with the notable exception of the bone marrow. The ability to continuously self-renew and produce the differentiated progeny of the tissue of their location are their defining properties. Identifying surface molecules (markers) that would aid in stem cell isolation is a major goal. Considerable overlap exists between different putative organspecific stem cells in their repertoire of gene expression, often related to self-renewal, cell survival and cell adhesion. More robust tests of 'stemness' are now being employed, using lineage-specific genetic marking and tracking to show production of long-lived clones and multipotentiality in vivo. Moreover, the characterization of normal stem cells in specific tissues may provide a dividend for the treatment of cancer. The successful treatment of neoplastic disease may well require the specific targeting of neoplastic stem cells, cells that may well have many of the characteristics of their normal counterparts.

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Section: Epigenetic Modificationsmentioning

confidence: 99%

Attributes of adult stem cells

Alison

Islam

2008

The Journal of Pathology

151

115

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“…11 As a consequence of this, a limited set of epigenetic modifications can indirectly alter the expression of hundreds to thousands of genes proving the efficiency of this type of control in establishing cellular identities. [11][12][13][14] DNA methylation is an epigenetic modification that results in the addition of a methyl group to cytosine residues of CpG dinucleotides. 15 The addition of this methyl group is catalyzed by DNA methyltransferases (DNMTs).…”

Section: The Role Of Dna Methylation In Embryonic Stem Cell Differentmentioning

confidence: 99%

“…For example, alterations in chromatin structure have been shown to influence gene expression during normal cellular differentiation and malignant transformation. 2,13 These findings led to the development of novel chemotherapeutic drugs including DNTM and HDAC inhibitors that are currently in clinical trials for the treatment of various cancer types. 77,78 Further analyses of normal epigenetic regulatory mechanisms and their aberrancies in cancer may lead to the discovery of new strategies for cancer diagnosis and treatment.…”

Section: Abnormalities Of Epigenetic Patterns In Cancermentioning

confidence: 99%

Epigenetic patterns of embryonic and adult stem cells

Bloushtain-Qimron

Yao²,

Shipitsin

et al. 2009

Cell Cycle

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“…In some disease developments, it has been found that acetylation plays an important role. For instance, the interplay of acetylation and methylation in gene transcription regulation is one of contributing factors in cancer development and has been investigated if patterns can be used for disease diagnosis [56]. Histone deacetylation inhibitors, if properly designed, can be used for tumour radiosensitization [57].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Metabolic Pathways with the Primary Structure in Acetylated Proteins

Yang¹,

Chou²

2008

TOBIOIJ

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Signaling pathways are the major component in cellular networks, but most studies done recently on signaling pathways were either aimed to enhance various molecular predictions using pathways as contexts or focused to predict pathways indirectly. The former assumed that the pathways for the biomolecules (genes or proteins) used in the modelling were known. Although the latter was well suiting the biosciences researches at the systems level, the indirect predictions would more or less rely on the prediction accuracy of other systems. So far no work whatsoever has been done for studying the direct correlation between signaling pathways and protein primary structures although acetylated proteins are one of the main players in metabolic signaling pathways. In order to investigate their correlation, the sequences of 76 experimentally verified acetylated proteins were downloaded from NCBI. They cover three major metabolic pathways, i.e., biosynthesis, degradation, and metabolism. Without any a prior knowledge about how these three metabolic pathways are correlated with the primary structures of acetylated proteins, we proposed some classification models between the pathways. It has been found through computer simulations that the signaling pathways are indeed correlated with the primary structures in acetylated proteins, further demonstrating the well-known biological law that sequence determines structure and structure determines function.

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Histone acetylation and chromatin signature in stem cell identity and cancer

Cited by 80 publications

References 104 publications

Attributes of adult stem cells

Attributes of adult stem cells

Epigenetic patterns of embryonic and adult stem cells

Correlation of Metabolic Pathways with the Primary Structure in Acetylated Proteins

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