Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis

Xu, Cheng‐Ran; Liu, Cui; Wang, Yilan; Li, Lin‐Chen; Chen, Wenqian; Xu, Zhi-Hong; Bai, Shu-Nong

doi:10.1073/pnas.0503143102

Cited by 145 publications

(146 citation statements)

References 35 publications

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“…Except for AtHDA18, nothing is known about the function of class II HDACs in Arabidopsis. AtHDA18 has been recently reported to control the positiondependent expression of genes involved in defining the pattern of the root epidermis (Xu et al, 2005).…”

Section: Arabidopsis Hdacsmentioning

confidence: 99%

Arabidopsis histone deacetylase 6: a green link to RNA silencing

et al. 2007

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Epigenetic reprogramming is at the base of cancer initiation and progression. Generally, genome-wide reduction in cytosine methylation contrasts with the hypermethylation of control regions of functionally wellestablished tumor suppressor genes and many other genes whose role in cancer biology is not yet clear. While insight into mechanisms that induce aberrant cytosine methylation in cancer cells is just beginning to emerge, the initiating signals for analogous promoter methylation in plants are well documented. In Arabidopsis, the silencing of promoters requires components of the RNA interference machinery and promoter double-stranded RNA (dsRNA) to induce a repressive chromatin state that is characterized by cytosine methylation and histone deacetylation catalysed by the RPD3-type histone deacetylase AtHDA6. Similar mechanisms have been shown to occur in fission yeast and mammals. This review focuses on the connections between cytosine methylation, dsRNA and AtHDA6-controlled histone deacetylation during promoter silencing in Arabidopsis and discusses potential mechanistic similarities of these silencing events in cancer and plant cells.

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Section: Arabidopsis Hdacsmentioning

confidence: 99%

Arabidopsis histone deacetylase 6: a green link to RNA silencing

et al. 2007

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“…Within this context, deacetylation of Lys residues in histones 3 and 4, catalyzed by histone deacetylases (HDACs), establishes a repressive mark (Kouzarides, 2007;Roudier et al, 2009). In plants, histone deacetylation supports fundamental life functions, including maintenance of genome stability (Probst et al, 2004;To et al, 2011;Liu et al, 2012), determination of cell-type specificity (Xu et al, 2005;Hollender and Liu, 2008), and transition between developmental stages (Tanaka et al, 2008;Yu et al, 2011). Gene repression through histone deacetylation is also an important part of the hormonal signaling pathways that orchestrate plant responses to biotic or abiotic stress factors in the environment (Zhou et al, 2005;.…”

Section: Introductionmentioning

confidence: 99%

Histone Deacetylase Complex1 Expression Level Titrates Plant Growth and Abscisic Acid Sensitivity in Arabidopsis

et al. 2013

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Histone deacetylation regulates gene expression during plant stress responses and is therefore an interesting target for epigenetic manipulation of stress sensitivity in plants. Unfortunately, overexpression of the core enzymes (histone deacetylases [HDACs]) has either been ineffective or has caused pleiotropic morphological abnormalities. In yeast and mammals, HDACs operate within multiprotein complexes. Searching for putative components of plant HDAC complexes, we identified a gene with partial homology to a functionally uncharacterized member of the yeast complex, which we called Histone Deacetylation Complex1 (HDC1). HDC1 is encoded by a single-copy gene in the genomes of model plants and crops and therefore presents an attractive target for biotechnology. Here, we present a functional characterization of HDC1 in Arabidopsis thaliana. We show that HDC1 is a ubiquitously expressed nuclear protein that interacts with at least two deacetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress. The fast-growing HDC1-overexpressing plants outperformed wild-type plants not only on well-watered soil but also when water supply was reduced. Our findings identify HDC1 as a rate-limiting component of the histone deacetylation machinery and as an attractive tool for increasing germination rate and biomass production of plants.

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“…It has been reported that histone deacetylation affects many growth and developmental events in plants, such as flowering time, cold tolerance, embryogenesis, root hair development, abscisic acid, and salt responses (34)(35)(36)(37)(38). A molecular link between this epigenetic control and JA signaling has been implied, as an RPD3-type histone deacetylase 6 (HDA6) was reported to associate with COI1 in a coimmunoprecipitation (co-IP) assay (39).…”

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confidence: 99%

Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis

Zhu

An²,

Feng³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Jasmonate (JA) and ethylene (ET) are two major plant hormones that synergistically regulate plant development and tolerance to necrotrophic fungi. Both JA and ET induce the expression of several pathogenesis-related genes, while blocking either signaling pathway abolishes the induction of these genes by JA and ET alone or in combination. However, the molecular basis of JA/ET coaction and signaling interdependency is largely unknown. Here, we report that two Arabidopsis ET-stabilized transcription factors (EIN3 and EIL1) integrate ET and JA signaling in the regulation of gene expression, root development, and necrotrophic pathogen defense. Further studies reveal that JA enhances the transcriptional activity of EIN3/EIL1 by removal of JA-Zim domain (JAZ) proteins, which physically interact with and repress EIN3/EIL1. In addition, we find that JAZ proteins recruit an RPD3-type histone deacetylase (HDA6) as a corepressor that modulates histone acetylation, represses EIN3/EIL1-dependent transcription, and inhibits JA signaling. Our studies identify EIN3/EIL1 as a key integration node whose activation requires both JA and ET signaling, and illustrate transcriptional derepression as a common mechanism to integrate diverse signaling pathways in the regulation of plant development and defense.root hair | Botrytis cinerea P lants are sessile organisms and face different environmental changes during their lifespan. To survive various abiotic and biotic stresses, plants synthesize a number of small molecules functioning as phytohormones to elaborately regulate their growth, development, and defense. Two types of phytohormonesethylene (ET) and jasmonate (JA)-are crucial for plant development and defense against necrotrophic fungi infections (1-3). Complicated modes of interaction between ET and JA have been documented in different processes. For example, ET strongly suppresses JA-induced wounding-responsive gene expression, but JA suppresses ET-induced apical hook formation (4, 5), indicative of their antagonisms. Upon necrotrophic fungi infections, plants can quickly produce ET and JA and induce the expression of downstream defense genes (like ERF1, ORA59, and PDF1.2) that help plants tolerate or fight against the fungal pathogens (1). Plants treated with exogenous JA or ET express high levels of defense genes (6, 7), and simultaneous treatment with JA and ET results in the highest expression (8). Nevertheless, in the ET or JA insensitive mutant (ein2 or coi1, respectively), JA and ET alone or in combination fail to induce the expression of those defense genes (8, 9), indicating that the two hormone-signaling pathways are required concomitantly for the activation of plant-defense response. These results suggest that JA and ET act synergistically and mutually dependently in regulating necrotrophic pathogen responses. However, the molecular details underlying such hormone synergy and signaling interdependency are currently unknown.ET is a gaseous hormone, which is perceived by its receptors and represses a Raf-like kinase CON...

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Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis

Cited by 145 publications

References 35 publications

Arabidopsis histone deacetylase 6: a green link to RNA silencing

Arabidopsis histone deacetylase 6: a green link to RNA silencing

Histone Deacetylase Complex1 Expression Level Titrates Plant Growth and Abscisic Acid Sensitivity in Arabidopsis

Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis

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