Histomorphometrische und histologische Untersuchungen zur morphokinetischen Wirkung von Furazolidon auf die Spermiogenese geschlechtsreifer Ratten

Abstract

The antispermatongenic effects of furazolidone on the testes of mature Wistar rats were investigated using histological and morphometric methods. The sections showed a varying degree of depopulation of the germinal epithelium, a shrinking and a deformation of the Tubuli contorti, and an enlargement of the intertubular lymphatic sinuses. The strain led to a standstill in the spermatogenesis at the primary-spermatocyte stage. After administering furazolidone, the following results could be seen: a weight loss of up to 42.1% and a decrease in testes volume by up to 30.2%; a decrease in the volume of the nuclei of the Leydig-cells by up to 51.6%; a reduction in the diameter, perimeter and area covered by Tubuli seminiferi contorti of up to 33.5%, 30.8%, and 53.4%, respectively; an increase in the number of Tubuli seminiferi contorti per mm2 by up to 44.8%; a decrease in the percentage of Tubuli seminiferi contorti of the total testes tissue by up to 39.1%.