Histomorphometric Indicators of Small Intestine in Piglets With Neonatal Diarrhea

The study presents the data on the level of expression of pro- and anti-inflammatory cytokines in piglets with gas-trointestinal diseases of bacterial etiology. The analysis of gene expression showed that the expression levels of IL-1α and IL-10 were significantly increased in sick piglets, while IL-1β lost its activity. During the histological examination, there were no differences between the structure of the intestines of sick and healthy piglets. However, cytological examination: of the samples obtained from sick piglets demonstrated alteration and a decrease in the adhesive barrier in the epithelium of intestinal villi.

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Level of Pro- And Anti-Inflammatory Cytokines in Piglets With Gastrointestinal Diseases of Bacterial Etiology

Михайлов

Shabunin

Vorotnikova

et al. 2021

Transactions of the Educational Establishment “Vitebsk the Order of “The Badge of Honor” State Academy of Veterinary Medicine

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Level of Cd-3 Lymphocytes in the Mucosa of the Small Intestine of Piglets in a Complex Therapy of Gastrointestinal Diseases of Bacterial Etiology

Vorotnikova

Shabunin

Михайлов

et al. 2021

Transactions of the Educational Establishment “Vitebsk the Order of “The Badge of Honor” State Academy of Veterinary Medicine

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For the experiment, 3 groups of 40 sick piglets at the age of 5-7 days were selected, in which gastrointestinal tract diseases of mixed bacterial etiology were recorded. The first group was the control one and underwent no treatment. The animals of group 2 were administered intramuscularly the drug "Quinokol". The animals of the third group were administered “Quinokol” in combination with GM-CSF. In the immunе histochemical studies the revealed level of CD-3 positive cells in the mucous membrane in group 3 was found higher than in groups 1 and 2 by 62% and 51%, respectively. This indicates the stimulation of the migration of T cells into the intestine to maintain local immunity.

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Histological Changes in Piglets With the Associative Course of Salmonellosis and Eimeriosis

Mironova

Pavlenko

et al. 2022

Transactions of the Educational Establishment “Vitebsk the Order of “The Badge of Honor” State Academy of Veterinary Medicine

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The article describes the microscopic changes found during the autopsy of piglets that died from the associative course of salmonellosis and eimeriosis. In case of the associative course of salmonellosis and eimeriosis, clinical forms of the disease are recorded: severe intestinal exicosis, an infectious-toxic form with a severe and very severe course and a severe toxic-dystrophic form. At the histological level, with a mixed course of salmonellosis and eimeriosis, typical changes in the small intestine were found in all cases: congestive hyperemia, edema, hemorrhages, fibrin, granular dystrophy and villous necrosis, granular dystrophy and necrosis of the glandular epithelium, proliferation; in the large intestine: congestive hyperemia and edema, hemorrhages, granular degeneration and necrosis of the crypt epithelium, fibrin, proliferation; in the liver: congestive hyperemia, edema, hemorrhages, granular and fatty degeneration of hepatocytes, dry milliary areactive necrosis, proliferation around the triads, granulomas in the parenchyma; in the kidney: intracapillary glomerulonephritis; granular dystrophy of the tubular epithelium, rhexis and pycnosis of the tubular epithelial nuclei, proliferation and hyperemia in the interstitium; in the heart: congestive hyperemia, hemorrhages, edema, granular dystrophy of myocardial fibers, milliary areactive dry necroses, Zenker’ necrosis, proliferation; in the lungs: congestive hyperemia, catarrhal bronchopneumonia, proliferation in the interstitium, alveolar emphysema; in the spleen: congestive hyperemia, edema, hemorrhage, follicular necrosis; in the mesenteric lymph nodes: congestive hyperemia, edema, hemorrhage, follicular hyperplasia; in the brain: congestive hyperemia, edema.

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Histomorphometric Indicators of Small Intestine in Piglets With Neonatal Diarrhea

Cited by 4 publications

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Level of Pro- And Anti-Inflammatory Cytokines in Piglets With Gastrointestinal Diseases of Bacterial Etiology

Level of Pro- And Anti-Inflammatory Cytokines in Piglets With Gastrointestinal Diseases of Bacterial Etiology

Level of Cd-3 Lymphocytes in the Mucosa of the Small Intestine of Piglets in a Complex Therapy of Gastrointestinal Diseases of Bacterial Etiology

Histological Changes in Piglets With the Associative Course of Salmonellosis and Eimeriosis

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