Histomorphometric Evidence of Hepatic Recovery of Rats Fed Repeatedly Heated Palm Oil

Abdeen, Mohammed Abdelrahim; Zaghloul, Dorrya Abd-Alla Mohammed; Saleh, Reda Awadallah; Abdelmalek, Adel

doi:10.21608/ejh.2021.57674.1415

Cited by 2 publications

(3 citation statements)

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“…Also, they added that congestion may be caused by loss of fluid from dilated vessels, so the vessels appeared to be filled with RBCs. On the other hand, Abdeen et al [36] explained vascular dilatation to the stimulation of Kupffer cells with consequent increase in the synthesis of nitric oxide which acts as a vasodilator.…”

Section: Discussionmentioning

confidence: 99%

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Histological Evaluation of the Effect of Lactoferrin on Experimentally Induced Liver Fibrosis in Adult Male Albino Rat

Badr,

Ibrahim,

Elkelany

2024

Egyptian Journal of Cell and Tissue Research

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Background: Carbon tetrachloride (CCl4)-induced liver fibrosis is a well-established model of hepatotoxicity. Lactoferrin (LF) is an iron-binding glycoprotein that has anti-inflammatory and antioxidant effects. Aim of the study: This study was made to demonstrate the ameliorating effect of lactoferrin versus CCL4 induced liver fibrosis in adult male albino rat using various biochemical and histological techniques. Materials & Methods: This study involved forty adult male albino rats that were randomly divided into 4 groups: group I represented the control group, group II received LF (100mg/kg/day) orally for 5 weeks, group III was intraperitoneally injected with CCL4 (1ml/kg/once a week, for five weeks) for induction of liver fibrosis, and group IV received LF and CCL4 concomitantly in the same dose and manner as groups II & III respectively. The liver specimens were processed for different biochemical, histological and immunohistochemical techniques. Morphometrical and statistical studies were also performed. Results: CCL4 group showed disorganization of liver architecture that was evidenced by light & electron microscopic examination. A significant increase of the mean area percentage of collagen fibers by Masson's Trichrome, immunopositive reaction of αSMA and CD133 along the sinusoids were also observed. Lactoferrin administration in group IV showed improvement of all the previous results and oxidative stress biomarkers. Conclusion: Liver fibrosis could be ameliorated by lactoferrin.

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Section: Discussionmentioning

confidence: 99%

“…On the other hand, Abdeen et al [36] attributed mitochondrial abnormalities to reduced intra mitochondrial protein synthesis and rise of cytosolic calcium caused by oxidative stress and respiratory chain dysfunction.…”

Section: Fading Nuclei Of Hepatocytes and Karyolysis Observed In Curr...mentioning

confidence: 99%

Histological Evaluation of the Effect of Lactoferrin on Experimentally Induced Liver Fibrosis in Adult Male Albino Rat

Badr,

Ibrahim,

Elkelany

2024

Egyptian Journal of Cell and Tissue Research

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“…Additionally, dilatation of central veins and blood sinusoids were attributed to inflammatory changes or ischemia and hypoxia following a high-fat diet [29].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of autophagy induced by rapamycin versus intermittent fasting in animal model of fatty liver

Hosny,

Moustafa,

Mehina

et al. 2024

Folia Histochem Cytobiol.

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This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. www.journals.viamedica.pl/folia_histochemica_cytobiologica ©Polish Society for Histochemistry and Cytochemistry

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Histomorphometric Evidence of Hepatic Recovery of Rats Fed Repeatedly Heated Palm Oil

Cited by 2 publications

References 0 publications

Histological Evaluation of the Effect of Lactoferrin on Experimentally Induced Liver Fibrosis in Adult Male Albino Rat

Histological Evaluation of the Effect of Lactoferrin on Experimentally Induced Liver Fibrosis in Adult Male Albino Rat

Therapeutic effect of autophagy induced by rapamycin versus intermittent fasting in animal model of fatty liver

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