Histomorphometric and microarchitectural analysis of bone in metastatic breast cancer patients

Beltran-Bless, Ana-Alicia; Murshed, Monzur; Zakikhani, Mahvash; Kuchuk, Iryna; Bouganim, N.; Robertson, S.; Kekre, Natasha; Vandermeer, Lisa; Li, J.; Addison, Christina L.; Rauch, Frank; Clemons, M; Kremer, Richard

doi:10.1016/j.bonr.2021.101145

Cited by 1 publication

(2 citation statements)

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“…6 Given the profound impact that MBD can have on patients' quality of life and life expectancy, it is crucial for healthcare providers to have a thorough understanding of the molecular biology implicated in the development of bone metastases. 3,9,10 Knowledge of the microarchitecture and related molecular physiology of bones and cancer cells may function as a foundation for the development of potential therapeutic options. 3,7 The microenvironment of bones involves a dynamic interplay of several different types of cells including osteocytes, osteoblasts, osteoclasts, hematopoietic and immune cells, stromal cells, adipocytes, fibroblasts, and endothelial cells.…”

Section: Introductionmentioning

confidence: 99%

“…Given the profound impact that MBD can have on patients’ quality of life and life expectancy, it is crucial for healthcare providers to have a thorough understanding of the molecular biology implicated in the development of bone metastases 3,9,10 . Knowledge of the microarchitecture and related molecular physiology of bones and cancer cells may function as a foundation for the development of potential therapeutic options 3,7 .…”

Section: Introductionmentioning

confidence: 99%

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The dynamic microenvironment associated with metastatic bone disease: Current concepts

Bhale¹,

Ghosh²,

Theriault³

et al. 2023

Journal of Surgical Oncology

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Patients with bone metastases may experience debilitating pain, neurological conditions, increased risk of pathological fractures, and death. A deeper understanding of the bone microenvironment, the molecular biology of cancer types prone to metastasis, and how bone physiology promotes cancer growth, may help to uncover targeted treatment options. The purpose of this paper is to outline the current concepts relevant to topics including bone remodeling, angiogenesis, and immunomodulation as it relates to metastatic bone disease.

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