Histomorphometric and biochemical study of osteoclasts at orthodontic compression sites in the rat during indomethacin inhibition

Zhou, Daohong; Hughes, Bert; King, Gregory J.

doi:10.1016/s0003-9969(97)00070-8

Cited by 36 publications

(33 citation statements)

References 38 publications

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“…21–26 Indeed, key differences in odontoclastic and osteoclastic activity have been reported in the literature: a) the cell size – odontoclasts are smaller and have fewer nuclei when compared to osteoclasts; 21,25 b) regulation by systemic factors – dentin resorption, as opposed to bone resorption, is not regulated by parathyroid hormone (PTH), 27 and c) response to drugs – indomethacin seems to enhance root resorption but doesn’t interfere with bone resorption during orthodontic tooth movement. 28,29 Thus, the unusual pattern of tooth resorption in LAP patients here support previous research findings that osteoclasts and odontoclasts do not respond identically to inflammatory mediators. Our clinical and radiographic observations indicated that atypical patterns of external root resorption occurs and apical/physiological root resorption appears to occur more slowly while surrounding bone resorption occurs more aggressively around primary teeth in LAP patients.…”

Section: Discussionsupporting

confidence: 90%

Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition

Miller¹,

Treloar²,

Guelmann³

et al. 2018

Journal of Clinical Pediatric Dentistry

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Objectives Due to the low prevalence of localized aggressive periodontitis (LAP), clinical characteristics of LAP in primary dentition are derived from a few case reports/series in the literature. The goal of this study was to determine common clinical characteristics such as bone and root resorption patterns, in a series of cases with LAP in primary dentition. We hypothesize these cases present aggressive periodontal bone destruction starting mostly around first primary molars and atypical root resorption patterns. Study Design We have evaluated 33 LAP cases in primary dentition for pattern of bone destruction, root resorption and early exfoliation. Results Cases evaluated were aged 5–12 (mean=8.7 years). Thirty cases presented more severe bone loss on first than second molars, with relatively fast progression to second molars, altered pattern of root resorption, mostly external (n=16) and early exfoliation of primary teeth due to periodontal bone loss, rather than physiologic root resorption (n=11). Conclusions This study showed common clinical characteristics found in LAP in primary molars, including possible initiation on first primary molars and abnormal root resorption patterns. These characteristics are important to be early identified and treated in order to prevent possible progression into the permanent dentition.

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Section: Discussionsupporting

confidence: 90%

Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition

Miller¹,

Treloar²,

Guelmann³

et al. 2018

Journal of Clinical Pediatric Dentistry

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“…Osteoclasts and odontoclasts are implicated in the root resorption process (10). In experimental rats, the extent of root resorption is reported to increase only when force reactivation is performed at the peak count of osteoclasts in the involved region (12,13). Several studies have reported the involvement of multinucleated tartrate-resistant acid phosphatase-positive giant cells without ruffled borders in the removal of hyaline tissue.…”

Section: Introductionmentioning

confidence: 99%

Lithium chloride attenuates root resorption during orthodontic tooth movement in rats

Wang

Gao

Jiang

et al. 2013

Experimental and Therapeutic Medicine

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Root resorption is a common side effect of orthodontic treatment. In the current study, lithium chloride (LiCl), a Wnt signaling activator, was examined to determine its effect on root resorption. In total, 10 Sprague Dawley rats were randomly allocated into the experimental group (EG) and control group (CG). Each group consisted of five subjects. By using closed nickel-titanium coil springs, a 50-g force was applied between the upper incisors and the maxillary right first molars in order to mimic orthodontic biomechanics in the EG and CG for 14 days. During the 14 days, the EG rats were gavage-fed 200 mg/kg LiCl every 48 h. Next, digital radiographs were captured using a micro-computational tomography scanner. The movement of the maxillary first molars and the root resorption area ratio were measured electronically on the digital radiographs. The outcomes were analyzed using ANOVA. Following 14 days of experimental force application, all rats had spaces of varying sizes between the first and second right maxillary molars. The average distance measured in the CG was slightly higher than in the EG, however, the difference was not found to be statistically significant (P=0.224). Root resorption craters were observed in the groups following the experiment. Rough cementum areas were observed on the mesial surface of the distobuccal and distopalatal roots. The mean root resorption area ratio of CG was significantly greater than EG (P<0.05). Results of the present study indicate that LiCl can attenuate orthodontically induce root resorption during orthodontic tooth movement. The effect of LiCl on tooth movement is insignificant.

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“…Efeito de diminuição da taxa de movimentação foi conseguido quando da administração de indometacina 3,16,50 ; acetato de cortisona 41 , bifosfanatos 1,15 . No presente estudo, utilizou-se a avaliação após 14 dias de movimentação o que possibilita a comparação com resultados da literatura tendo em vista que a maioria dos estudos de curta duração com animais são totalmente comparáveis com as feitas em seres humanos 29 .…”

Section: Resultsunclassified

“…Vários medicamentos foram estudados quanto à possibilidade de interferência no movimento dentário ortodôntico. Entre eles, estão os estudos com ácido acetilsalicílico 8,30,44 , indometacina 3,8,43,45,48,50 , anticoncepcionais 25,35 , corticosteróides 2,9,41 , diazepam 23 e dipirona 34 . Agentes ansiolíticos e anticonvulsivantes afetam o remodelamento ósseo, também podendo afetar os procedimentos ortodônticos devido à alteração da reação tissular e, conseqüentemente, o movimento dentário 7,11,18,32,39,45,47 .…”

Section: Introductionunclassified

Avaliação clínica e radiográfica da influência do fenobarbital (Gardenal®) na movimentação ortodôntica: estudo em coelhos

Pithon

Ruellas

2008

Rev. Dent. Press Ortodon. Ortop. Facial

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Objetivo: Deste estudo foi avaliar clínica e radiograficamente a influência do Fenobarbital na movimentação ortodôntica. Metodologia: Foram utilizados 22 coelhos da raça Nova Zelândia (Oryctolagus cuniculus), distribuídos em três grupos: normal (N), controle (C) e experimental (E). O grupo N (n=2) não foi tratado, apenas certificada a condição de normalidade. Nos grupos C (n=10) e E (n=10), foi montado aparelho ortodôntico entre os primeiros molares e incisivos inferiores para promover a movimentação para mesial dos molares. No grupo E, foi administrado conjuntamente à movimentação dentária induzida, o medicamento Fenobarbial. Após os períodos de 7 e 14 dias os animais foram sacrificados para análise clínica e radiográfica. Conclusões: Os resultados demonstraram não haver diferenças na extensão do movimento nem alterações radiográficas entre os animais do grupo controle e experimental. ResumoPalavras-chave: Movimentação dentária. Medicamentos. Ortodontia. A r t i g o i n é d i t o INTRODUÇÃOCom relativa freqüência, observa-se grande número de pessoas que utilizam medicamentos 10 , muitos dos quais decorrentes de auto-medicação, efeito contraceptivo, tratamento de doenças crô-nicas ou uso crônico por pacientes idosos 42 . Desta forma torna-se imperioso o conhecimento do mecanismo de ação destas substâncias por parte do Cirurgião-Dentista, bem como as possíveis interações que podem ocorrer, de forma a beneficiar o tratamento ou ajustá-lo aos efeitos sobre o sistema estomatognático.O sucesso do tratamento ortodôntico depende, entre outros fatores, da remodelação óssea. A remodelação óssea bem sucedida durante o movimento dentário, apresentava vantagem de promover menor dano histológico, menor dor e movimento dentário mais rápido, resultando em menor período de tratamento 24 . O movimento dentário ortodôntico ocorre quando forças são aplicadas sobre os dentes 40 e são transmitidas ao periodonto de suporte 29 , fazendo com que modifiquem sua posição em relação às estruturas que os rodeiam 40 pelo mecanismo de remodelamento do osso alveolar 36 . Ou seja, aposição óssea na área tracionada e absorção óssea na área pressionada 14,21,26,29,36,40 . Além do conhecimento profundo sobre movi-

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Histomorphometric and biochemical study of osteoclasts at orthodontic compression sites in the rat during indomethacin inhibition

Cited by 36 publications

References 38 publications

Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition

Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition

Lithium chloride attenuates root resorption during orthodontic tooth movement in rats

Avaliação clínica e radiográfica da influência do fenobarbital (Gardenal®) na movimentação ortodôntica: estudo em coelhos

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