Histomorphometric analysis following augmentation of the posterior mandible using cancellous bone‐block allograft

Abstract

The present study was conducted to histologically and histomorphometrically evaluate the application of cancellous bone-block allografts for the augmentation of the posterior atrophic mandible. Twenty-four consecutive patients underwent augmentation with cancellous bone-block allografts in the posterior mandible. A bony deficiency of at least 3 mm horizontally and/or vertically according to CT para-axial reconstruction served as inclusion criteria. Following 6 months, 85 implants were placed and a cylindrical sample core was collected. All specimens were prepared for histological and histomorphometrical examination. Implant survival rate was 95.3%. Follow-up ranged 12-66 months (mean 43 ± 19 months). The mean newly formed bone was 44 ± 28%, that of the residual cancellous bone-block allograft 29 ± 24%, and of the marrow and connective tissue 27 ± 21%. Statistically significant histomorphometric differences regarding newly formed bone (69% vs. 31%, p = 0.05) were found between younger (< 45 years) and older (> 45 years) patients, respectively. Histomorphometric differences regarding residual cancellous bone-block allograft (17% vs. 35%) and of the marrow and connective tissue (14% vs. 34%) were not statistically significant. Cancellous bone-block allograft is biocompatible and osteoconductive, permitting new bone formation following augmentation of extremely atrophic posterior mandible with a two-stage implant placement procedure. New bone formation was age-dependent.

Treatment of Severely Resorbed Maxilla Due to Peri-Implantitis by Guided Bone Regeneration Using a Customized Allogenic Bone Block: A Case Report

“…The present results show an optimal integration behavior of the FDBA block after six months 173 and the formation of new vital bone, which is comparable to values found in case of other 174 treatment options for such kind of defects. 15,16 Thus, the analyses of the present case report 175 confirm the use of the customized CAD/CAM bone block for augmentation of a complex defect 176 in the maxillary aesthetic zone as a successful treatment concept.…”

The Use of Cancellous Bone-Block Allograft for Reconstruction of the Atrophic Alveolar Ridge

“…Our findings of a significantly greater percentage of new bone formation in younger patients relative to older ones following remodeling with cancellous block-allograft in the anterior atrophic maxilla and posterior atrophic mandible (Nissan et al, 2011d;Nissan et al, 2011e) agree with earlier studies of the effect of age on new bone formation (Fisher et al, 2010;Matsumoto et al, 2001;Rando, 2006;Tanuka et al, 1996;Walboomers et al, 2006). Following induction of injury to the tibia marrow cavity in a rat model, MicroCT and histomorphometry revealed a reduced response with an increase in age, suggesting that the restoration of normal tissue is age-dependent (Fisher et al, 2010).…”

“…Division of the patients by age (less or more than 45 years) yielded statistically significant differences in the percentage of newly formed bone (69% vs. 31%, respectively; P = 0.05), but not in the percentage of residual cancellous block-allograft (17% and 5%) or marrow and connective tissue (14% and 34%). There were no statistically significant histomorphometric differences in percentage of newly formed bone by patient sex or presence/absence of soft tissue dehiscence (Nissan et al, 2011d). …”

“…There was no evidence of acute or chronic inflammatory infiltrate (Chaushu et al, 2010b;Nissan et al, 2011d;Nissan et al, 2011e).…”

Estudo da regeneração óssea guiada em mandíbula de ratos idosos

“…Esse insucesso foi atribuído à falta de aporte sanguíneo no idoso (Smolka et al, 2006). Uma formação óssea menor no idoso foi tambem descrita para aloenxerto em bloco inserido em maxila atrófica, (Nissan et al, 2012).…”