Histomorphometric Analysis and Regional Variations of Full Thickness Skin Grafts in Dogs

Bhandal, Jitender; Langohr, Ingeborg M.; Degner, Daniel A.; Stanley, Brian; Walshaw, Richard

doi:10.1111/j.1532-950x.2012.00987.x

Cited by 10 publications

(8 citation statements)

References 4 publications

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“…The difference in the epidermis thickness depends on the dog's body, but it does not affect the electric field distribution at simulated tissues (data not shown). The epidermis and SC thickness of dogs (0.020 mm ) are thinner than those of humans (0.051 mm ). The dermis is the second layer of skin, beneath the epidermal layer.…”

Section: Discussionmentioning

confidence: 88%

“…Figure shows the results of a superficial dermal tumor model. The epidermis and SC thickness is 0.06 mm , dermis thickness is 1 mm , muscle thickness is 5 mm , and tumor diameter is 2.9 mm. The thickness values are applied for dogs.…”

Section: Resultsmentioning

confidence: 99%

“…The dermis is the second layer of skin, beneath the epidermal layer. This layer is much thicker than the epidermis; the dermis thickness of humans is 50 µm on the eyelids to 1 mm on the palms and soles, with an average thickness of 100 µm , whereas that of a dog is 800 µm to 1.5 mm . As shown in Fig.…”

Section: Discussionmentioning

confidence: 96%

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Numerical Model of Dog Mast Cell Tumor Treated by Electrochemotherapy

et al. 2014

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Electrochemotherapy is a combination of high electric field and anticancer drugs. The treatment basis is electroporation or electropermeabilization of the cell membrane. Electroporation is a threshold phenomenon and, for efficient treatment, an adequate local distribution of electric field within the treated tissue is important. When this local electric field is not enough, there is a regrown tumor cell; however, if it is stronger than necessary, permanent damage to the tissue occurs. In the treatment of dogs, electrochemotherapy is not yet an established treatment for mast cell tumor in veterinary medicine, although there are studies showing evidence of its effectiveness. In this study, we examined electrochemotherapy of dog mast cell tumor with numerical simulation of local electric field distribution. The experimental result was used to validate the numerical models. The effect of tumor position and tissue thickness (tumor in different parts of dog body) was investigated using plate electrodes. Our results demonstrated that the electrochemotherapy is efficient and flexible, and even when the tumor extends into the subcutis, the treatment with plate electrode eliminated the tumor cells. This result suggests that electrochemotherapy is a suitable method to treat mast cell tumors in dog.

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Section: Discussionmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

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Numerical Model of Dog Mast Cell Tumor Treated by Electrochemotherapy

et al. 2014

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“…Another three studies measured abdominal skin thickness by using skin biopsy. In those studies, skin thickness in normal dogs was reported as 1.3 ± 0.34 mm [ 25 ], 0.95 ± 0.11 mm [ 4 ], and 0.62 mm [ 27 ]. The results in the first two studies [ 4 25 ] were similar to the results of this study, probably because they measured beagles, a small dog breed.…”

Section: Discussionmentioning

confidence: 99%

“…In those studies, skin thickness in normal dogs was reported as 1.3 ± 0.34 mm [ 25 ], 0.95 ± 0.11 mm [ 4 ], and 0.62 mm [ 27 ]. The results in the first two studies [ 4 25 ] were similar to the results of this study, probably because they measured beagles, a small dog breed. The results of another study [ 27 ] showed significantly thinner skin than the mean skin thickness of this study, but the breed was not identified.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic evaluation of skin thickness in small breed dogs with hyperadrenocorticism

2018

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The purpose of this study was to propose a standard for differentiation between normal dogs and patients with hyperadrenocorticism (HAC) by measuring skin thickness via ultrasonography in small breed dogs. Significant changes in skin thickness of patients treated with prednisolone (PDS) or patients with HAC treated with trilostane were evaluated. Skin thickness was retrospectively measured on three abdominal digital images obtained from small breed dogs weighing < 15 kg that underwent abdominal ultrasonography. Mean skin thickness of normal dogs was 1.03 ± 0.25 mm (mean ± SD). Both the HAC and PDS groups showed significantly thinner skin than that in the normal group. Seven of the 10 HAC patients treated with trilostane had increased skin thickness. The area under the curve value of 0.807 was based on the receiver operating characteristics (ROC) curve for differentiating normal dogs from HAC patients. Sensitivity was 76% and specificity was 73% when skin thickness was less than the 0.83 mm cutoff value. In conclusion, measurement of skin thickness in small breed dogs by using ultrasonography is likely to provide clinical information useful in differentiating HAC patients from normal dogs. However, exposure to PDS, trilostane, and other conditions may have a significant effect on skin thickness.

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Degloving and Shear Injuries

Stanley

2015

Small Animal Surgical Emergencies

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Histomorphometric Analysis and Regional Variations of Full Thickness Skin Grafts in Dogs

Abstract: Thickness of the epidermis and dermis is dependent on body region. Hair follicle density in the FTSG specimens was decreased compared with intact skin specimens, which may affect hair regrowth in FTSG.

Cited by 10 publications

References 4 publications

Numerical Model of Dog Mast Cell Tumor Treated by Electrochemotherapy

Numerical Model of Dog Mast Cell Tumor Treated by Electrochemotherapy

Ultrasonographic evaluation of skin thickness in small breed dogs with hyperadrenocorticism

Degloving and Shear Injuries

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