Histomorphology of the hypobranchial gland in Dicathais orbita (Gmelin, 1791) (Neogastropoda: Muricidae)

Westley, Chantel Barbara; Lewis, Michelle C.; Benkendorff, Kirsten

doi:10.1093/mollus/eyp056

Cited by 13 publications

(21 citation statements)

References 26 publications

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“…Tyrian purple is thought to be synthesized from dietary derived tryptophan in the Muricidae [4,43]. Tryptophan has been detected in the hypobranchial secretory cells of several Muricidae species [14,15]. It is particularly prevalent in the rectum of D. orbita , which is embedded in the hypobranchial gland [15,18].…”

Section: A Biological Basis For Future Natural Products Researchmentioning

confidence: 99%

“…Tryptophan has been detected in the hypobranchial secretory cells of several Muricidae species [14,15]. It is particularly prevalent in the rectum of D. orbita , which is embedded in the hypobranchial gland [15,18]. Although it remains unclear how this amino acid is specifically converted into tyrindoxyl sulfate in Muricidae, several biosynthetic enzymes are likely to be involved (Table 3).…”

Section: A Biological Basis For Future Natural Products Researchmentioning

confidence: 99%

“…Over a century later, there remain major gaps in our knowledge of the ecological role and biosynthesis of this secondary metabolite [4,5]. However, significant progress has been made by Australian researchers over the last five decades [1,6,7,8,9,10,11,12,13,14,15], thus providing a foundation for using D. orbita as model species in natural products research.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed D. orbita is a relatively large, long-lived gastropod that is common on rocky reefs in temperature Australian waters [33,37,38,39] and it also occurs as a pest predator on some molluskan aquaculture farms [40]. This species produces benthic egg capsules that each contain thousands of embryos that can be studied through several stages of larval development [41] and the reproductive cycle and anatomy of the adults is well documented [15,42,43]. D. orbita is resilient to environmental fluctuations [pers.…”

Section: Introductionmentioning

confidence: 99%

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Natural Product Research in the Australian Marine Invertebrate Dicathais orbita

Benkendorff

2013

Marine Drugs

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The predatory marine gastropod Dicathais orbita has been the subject of a significant amount of biological and chemical research over the past five decades. Natural products research on D. orbita includes the isolation and identification of brominated indoles and choline esters as precursors of Tyrian purple, as well as the synthesis of structural analogues, bioactivity testing, biodistributional and biosynthetic studies. Here I also report on how well these compounds conform to Lipinski’s rule of five for druglikeness and their predicted receptor binding and enzyme inhibitor activity. The composition of mycosporine-like amino acids, fatty acids and sterols has also been described in the egg masses of D. orbita. The combination of bioactive compounds produced by D. orbita is of interest for further studies in chemical ecology, as well as for future nutraceutical development. Biological insights into the life history of this species, as well as ongoing research on the gene expression, microbial symbionts and biosynthetic capabilities, should facilitate sustainable production of the bioactive compounds. Knowledge of the phylogeny of D. orbita provides an excellent platform for novel research into the evolution of brominated secondary metabolites in marine molluscs. The range of polarities in the brominated indoles produced by D. orbita has also provided an effective model system used to develop a new method for biodistributional studies. The well characterized suite of chemical reactions that generate Tyrian purple, coupled with an in depth knowledge of the ecology, anatomy and genetics of D. orbita provide a good foundation for ongoing natural products research.

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Section: A Biological Basis For Future Natural Products Researchmentioning

confidence: 99%

Section: A Biological Basis For Future Natural Products Researchmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Natural Product Research in the Australian Marine Invertebrate Dicathais orbita

Benkendorff

2013

Marine Drugs

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“…Peptidyl-dipeptidase A 548 expression (Table 5) suggests a link between the hypobranchial gland and 549 vasoconstriction/vasodilation (Salzet et al, 2001). The hypobranchial gland has been 550 described as highly vascularised tissue (Fretter and Graham, 1994), located in close 551 proximity to the vascular sinus (Westley et al, 2010). Consequently these genes could 552 be involved in regulating blood vessels and blood supply to this metabolically active 553 biosynthetic organ.…”

Section: Gene Expression Comparisons 398mentioning

confidence: 99%