Histomorphology and grading of regression in gastric carcinoma treated with neoadjuvant chemotherapy

Abstract

The viscoelastic properties of filled elastomers (uncured styrene–butadiene rubber filled with carbon black) were investigated with two shear rheometers specially designed for the characterization of complex polymer systems. A torsional strain‐controlled rheometer [i.e., a rubber process analyzer (RPA)] was used in dynamic and relaxation modes for measuring the storage and loss moduli and the relaxation modulus. A stress‐controlled sliding cylinder rheometer (SCR) was operated for the measurement of the creep compliance. Both devices could be operated on a large scale of imposed strains or stresses ranging from the linear viscoelastic regime to the nonlinear viscoelastic regime, and they were complementary in supporting the original viscoelastic behavior of filled elastomers for a wide experimental time range. Moreover, when the measuring ranges of the two apparatus overlapped, a cross‐check of the material functions obtained with the RPA or SCR could be successfully carried out. This validation of the data was performed not only in the linear domain of viscoelasticity, with the classical approach of a generalized Maxwell model, but also in the nonlinear domain, with a viscoelastic integral model of type K‐BKZ. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 87: 31–41, 2003

Validity of response assessment criteria in neoadjuvant chemotherapy for gastric cancer (JCOG0507-A)

“…There are several different histological grading systems for the evaluation of tumor responses in addition to that defined by the JCGC. Becker et al [14,15] proposed the following system: tumors with no viable cells are assigned grade Ia; tumors with 1-10 % viable cells, grade Ib; tumors with 10-50 % viable cells, grade II; and tumors with more than 50 % viable cells, grade III. Ajani et al [16,17] proposed a grading scheme: cases showing either an absence of tumor cells or necrosis in more than 90 % of the resected tumor were classified as responders.…”

The predictive value of molecular markers (p53, EGFR, ATM, CHK2) in multimodally treated squamous cell carcinoma of the oesophagus

“…Regarding nodal status, 62 tumours were in category ypN0 and 32 in ypN1. The histopathological response to chemoradiotherapy was classified in accordance with criteria published previously (Becker et al, 2003;Brücher et al, 2006). The percentage of viable residual tumour cells was estimated, and individual patients were subsequently allocated to one of the following groups: no residual tumour cells; o10% residual tumour cells/tumour area; 10 -50% residual tumour cells; and 450% residual tumour cells.…”

Determination of the optimal cutoff percentage of residual tumors to define the pathological response rate for gastric cancer treated with preoperative therapy (JCOG1004-A)

“…Various definitions regarding the cutoff percentage of residual tumors such as 10 % [7][8][9][10][11][12], 40 % [13], 50 % [9,14], or 67 % [15][16][17][18][19][20][21][22][23] have been used in previous clinical trials. According to the criteria proposed by Becker et al [24,25], 10 or 50 % is typically used as the cutoff percentage in Western countries, while 33 or 67 % is commonly used in Asian countries following the definition specified in the Japanese Classification of Gastric Carcinoma [26]. These differences in definitions between the East and West essentially impair the comparability of pathRRs between trials.…”