Histomorphological study of the reparation process in the optic nerve in experimental chronic alcoholic intoxication after treatment with polyoxidonium

Abstract

Õàðüêîâñêàÿ ìåäèöèíñêàÿ àêàäåìèÿ ïîñëåäèïëîìíîãî îáðàçîâàíèÿ, ã. Õàðüêîâ; ÊÓ Ñóìñêàÿ îáëàñòíàÿ êëèíè÷åñêàÿ áîëüíèöà, ã. Ñóìû* Ïðîâåäåíî ã³ñòîìîðôîëîã³÷íå äîñë³äaeåííÿ ïðîöåñ³â ðåïàðàö³¿ ï³ñëÿ ë³êóâàííÿ ïðåïàðàòîì ïîë³-îêñèäîí³é ó ³íòðàáóëüáàðíîìó, ðåòðîáóëüáàðíîìó, èíòðàêàíàë³êóëÿðíîìó òà ³íòðàêðàí³àëüíîìó â³ä-ä³ëàõ çîðîâîãî íåðâà ïðè éîãî óðàaeåíí³ âíàñë³äîê õðîí³÷íî¿ àëêîãîëüíî¿ ³íòîêñèêàö³¿ â åêñïåðèìåíò³. Äîñë³äaeåííÿì, ïðîâåäåíèì íà 24 êðîëèêàõ ñàìöÿõ ïîðîäè øèíøèëà, âñòàíîâëåíî, ùî ï³ñëÿ ë³êóâàííÿ â óñ³õ äîñë³äaeåíèõ â³ää³ëàõ çîðîâîãî íåðâó: 1) ïðèïèíÿþòüñÿ ïðîöåñè àëüòåðàö³¿, íà ùî âêàçóº çíèêíåííÿ ìîðôîëîã³÷íèõ îçíàê ðîçïàäó 쳺ë³íîâèõ îáîëîíîê íåðâîâèõ âîëîêîí; 2) ð³çêî àêòèâ³çóþòüñÿ êîìïåíñàòîðíî-ïðèñòîñóâàëüí³ òà ðåãåíåðàòîðí³ ïðîöåñè, ùî ìîðôîëîã³÷íî âèðàaeàºòüñÿ ã³ïåðïëà糺þ ñóäèííî¿ ñ³òêè òà íåðâîâèõ âîëîêîí çîðîâîãî íåðâà. Çâàaeàþ÷è íà ïîçèòèâíèé âïëèâ ë³êóâàííÿ ïðåïàðàòîì ïîë³îêñèäîí³é íà ïðîöåñè ðåãåíåðàö³¿ â çîðîâîìó íåðâ³ ï³ñëÿ ïðèïèíåííÿ âaeèâàííÿ àëêîãîëþ, à òàêîae â³äñóòí³ñòü ìîðôîëîã³÷íèõ îçíàê ñòèìóëÿö³¿ àóòî³ìóííèõ ïðîöåñ³â, ñèíòåòè÷íèé ³ìóíîìîäóëÿòîð ïîë³îêñèäîí³é ìîaeíà ââàaeàòè ïåðñïåêòèâíèì äëÿ ë³êóâàííÿ òîêñè÷íî¿ îïòè÷íî¿ íåéðîïàò³¿ àëêîãîëüíîãî ´åíåçó ó ëþäåé.