Histomorphological Patterns of Endometrium in Infertility

Nandedkar, Shirish; Patidar, Ekta; Gada, Dhiraj; Malukani, Kamal; Munjal, Kavita; Varma, Amit

doi:10.1007/s13224-014-0614-4

Cited by 13 publications

(15 citation statements)

References 3 publications

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“…Endometrium reflects the pathophysiological state of hypothalamic-pituitary-ovarian complex as well as serve as bed and bread of the early embryo. [1] Endometrial lesions are quite common among reproductive as well as females in postmenopausal age groups. Abnormal uterine bleeding (AUB) is a common gynaecological complain associated with significant morbidity and hinders patients personal, family and social life as well.…”

Section: Introductionmentioning

confidence: 99%

Histopathological and Immunohistochemical Study of Endometrial Lesions Obtained from D&C and Hysterectomy Specimens at a Tertiary Care Hospital

Bhattacharya

Jha²,

Agarwal³

et al. 2018

APALM

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Background: Endometrial lesions are represented by a set of diversified disorders which has challenged clinicians for a long time. Due to its chances of progressing to malignant states, the condition needs prompt and focussed study, keeping clinical context in view. Methods: This 12-month (June 2016-May 2017) cross-sectional studyinvolved 100 specimens from dilatation and curettage (D & C) and hysterectomy specimens from female patientsaged ≥ 18 years who presented with complain of pelvic pain, abnormal uterine bleeding, dysmenorrhoea, pelvic mass and infertility. For all the specimens received,histopathological and immunohistochemical assessment was done. Results: Out of 100 cases of abnormal uterine bleeding 44 females showed physiological changes, 25 females showed benign lesions and 20 females had malignant lesions of endometrium. Out of 20 cases of endometrial carcinoma 50 % were well differentiated and 25% were moderately differentiated and 25% were poorly differentiated. Expression of Ki-67 was >35% in poorly differentiated carcinoma. Well differentiated carcinoma showed 80-85% positivity of ER, moderately differentiated showed 30-35% positivity and poorly differentiated carcinoma showed 6-12%. The association between benign and malignant endometrial lesion was found to be statistically significant with age-group, history of contraceptive use and chronic illnesses (p<0.05). Conclusion: Endometrial biopsy is one of the prompt tools in diagnosis and assessment of the benign and malignant diseases of endometrium. Immunohistochemical markers like ER (hormonal receptor) and Ki-67 (proliferative marker) play a major role in diagnosis, prognostication and therapeutic management of malignant cases.

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Section: Introductionmentioning

confidence: 99%

Histopathological and Immunohistochemical Study of Endometrial Lesions Obtained from D&C and Hysterectomy Specimens at a Tertiary Care Hospital

Bhattacharya

Jha²,

Agarwal³

et al. 2018

APALM

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“…This suggests that glycogen is present in traces in the proliferative phase and increases progressively during the secretory phase [15,16,17,18]. and were asymptomatic (37%) [19,20,21]. Among the patients with primary infertility, nine endometria were in proliferative phase (24.3%) and 28 endometria were in secretory phase (75.7%).…”

Section: Resultsmentioning

confidence: 99%

A Correlative Study of Endometrial Glycogen Content in Female Infertility

Rajan

Parijatham

Srivastava

2021

JPRI

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Infertility is a global problem. It has been viewed as a discredit and social humiliation thrust upon healthy young adults. The present detects the glycogen content in the endometrial glands of infertile women in the age group of 18 -39 years. This study aimed to compare infertility and the glycogen content in the endometrial glands of fertile women of the same age group. The endometrium is the tissue of attention because it is the site for implantation of ovum. The current study was done to evaluate the glycogen content in the endometrium of infertile patients and compare it with that of fertile patients. This study was done on 60 cases and 20 controls. Our study showed that large masses of glycogen (++++) was seen in only 7 secretory endometria in infertile cases (14.9%) when compared to 14 secretory endometria infertile subjects (77.7%). Also, endometrial glycogen grading in the secretory phase in infertile patients showed glycogen depletion (Grade 0) in 13 cases (27.7%) whereas it was nil in the fertile group. Glycogen is an essential and straight source of nutrient for the primary concepts and also helps in the successful implantation of blastocyst and continuation of pregnancy.

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“…The endometrial biopsy is very precious for an infertile woman and a lot depends on its correct diagnosis especially in cases of primary infertility. 11 The level of disagreement between consultants can be of value in identifying problems lying in the interpretation of biopsies. The main reason for variability in diagnosing endometrial biopsy is subjective interpretation of Noye's method which does not have precise enough objective criteria.…”

Section: Discussionmentioning

confidence: 99%

Endometrial Biopsies;

Nasir

Khan

Sharif

et al. 2018

TPMJ

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… Background: In histopathology, inter-observer variability is frequently encounter leading to diagnostic dilemma. Endometrial biopsies are one of them where multiple factors including hormonal influences make the interpretation difficult. The aim of the article was to find the interobserver variability level between two consultants on endometrial biopsies by applying kappa and ICC analysis. Study Design: Prospective study. Setting: . Methods: This study consisted of 102 endometrial biopsies of infertile women on 22 nd or 23 rd day of menstrual cycle. All cases were examined by two consultants separately and formed their opinions independent of each other according to Noye's criteria. Their opinions were categorized as those in agreement, with minor disagreement and with major difference in opinion. Results: Agreement of opinion was established only in 34 (33.3%) cases. There was disagreement in 68 (66.7%) of cases. Out of these 68 cases, 46 (68%) belonged to the category of major conflicting opinion. In case of minor conflicting opinion, there was difference in specific day of the phase of menstrual cycle. The Kappa coefficient and ICC statistics was performed which gave the overall results as fair agreement. Conclusion:The main cause of disagreement was difficulty in applying the criteria for effects of hormonal influences on endometrial biopsies leading to subjective interpretation.

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Histomorphological Patterns of Endometrium in Infertility

Cited by 13 publications

References 3 publications

Histopathological and Immunohistochemical Study of Endometrial Lesions Obtained from D&C and Hysterectomy Specimens at a Tertiary Care Hospital

Histopathological and Immunohistochemical Study of Endometrial Lesions Obtained from D&C and Hysterectomy Specimens at a Tertiary Care Hospital

A Correlative Study of Endometrial Glycogen Content in Female Infertility

Endometrial Biopsies;

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