Histomorphological Diagnosis of Ulcerative Colitis and Associated Conditions

Jeruc, Jera

doi:10.5772/intechopen.102364

Cited by 2 publications

(1 citation statement)

References 75 publications

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“…Unlike Crohn’s disease, where the mucosa surrounding the ulcers may or may not be inflamed, ulcers in UC are virtually invariably accompanied by mucosal inflammation ( 5 ). Interleukins (ILs), important components of the cytokine profile observed in the gastrointestinal mucosa in UC, have therefore been emphasized as potential targets for targeted therapeutics in the future.…”

Section: Introductionmentioning

confidence: 99%

Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis

Ashique¹,

Mishra

Garg

et al. 2023

Front. Nutr.

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Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because of an improperly managed immunological reactivity to the intestinal microbiota found in the GIT. The immune response to common commensal microbes plays an essential role in intestinal inflammation related to UC synbiotics, and it is an important element in the optimal therapy of UC. Therefore, synbiotics, i.e., a mixture of prebiotics and probiotics, may help control the diseased state. Synbiotics alleviate the inflammation of the colon by lowering the reactive oxygen species (ROS) and improving the level of antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD). Prebiotic supplementation is not a common practice at the moment, despite numerous research findings proving that the benefits of both probiotics and prebiotics encourage their continued existence and positioning in the GIT, with positive effects on human health by managing the inflammatory response. However, the fact that there have been fewer studies on the treatment of UC with different probiotics coupled with selected prebiotics, i.e., synbiotics, and the outcomes of these studies have been very favorable. This evidence-based study explores the possible role of ROS, SOD, and synbiotics in managing the UC. The proposed review also focuses on the role of alteration of gut microbiota, antioxidant defense in the gastrointestinal tract, and the management of UC. Thus, the current article emphasizes oxidative stress signaling in the GI tract, oxidative stress-based pathomechanisms in UC patients, and UC therapies inhibiting oxidative stress’ effects.

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Section: Introductionmentioning

confidence: 99%

Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis

Ashique¹,

Mishra

Garg

et al. 2023

Front. Nutr.

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Histopathological Features in Relapse of Ulcerative Colitis.

Iqbal¹,

rehman²,

Henna³

et al. 2023

J Allam Iqbal Med Coll Lahore

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Background and objective: To determine the frequencies of various histopathological parameters of relapse in previously diagnosed cases of ulcerative colitis .Study Design: Cross sectional type. Setting: Histopathology department at Sheikh Zayed hospital Lahore. Duration: Six months period from 1/6/2014 to 1/12/2014.Methods: Two hundred and seventy colonic biopsies were assessed using 3% margin of error and 95% of the confidence level. Patients clinically relapsed with ulcerative colitis including both genders in age group from 11 to 80 years were included. Biopsy specimen fixed in 10% formalin were received. Processing was done and sections stained with hematoxylin and were examined by the pathologist. College of Physicians and Surgeons Pakistan gave approval for this study. Data was then analyzed and entered by the SPSS version15.Results: Total number of patients were 270,out of which all of the patients have shown chronic inflammation and increase number of neutrophils in lamina propria (100%), focal lymphoid aggregate in 162/270(60%), increased number of eosinophils in lamina propria in 108/270(40%), cryptitis in 216/270(80%), crypt distortion in 202/270(75%), mucin depletion in151/270 (56%) and crypt abscess formation in 148/270(55%). Conclusion: Hence, cryptitis and crypt abscess were observed to be most commonly occurring significant and reliable indicators of relapse in ulcerative colitis.

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Histomorphological Diagnosis of Ulcerative Colitis and Associated Conditions

Cited by 2 publications

References 75 publications

Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis

Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis

Histopathological Features in Relapse of Ulcerative Colitis.

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