Histometric Evaluation of Bone Regeneration Around Immediate Implants Partially in Contact With Bone

Enamel Matrix Derivative and Bone Healing After Guided Bone Regeneration in Dehiscence‐Type Defects Around Implants. A Histomorphometric Study in Dogs

“…37 The use of growth factors to treat osseous defects around implants has shown promising results. [16][17][18] The differences among the studies in the type of defects and the length of healing make comparisons with the present study difficult. However, it can be observed from the study by Becker et al 16 that the association of PDGF/IGF-I with ePTFE membranes may provide a superior percentage of implant surface in contact with bone (41.0%) when compared to ePTFE membranes alone (23.1%).…”

“…The results of the study questioned the use of DFDBA and supported the use of ePTFE membranes alone or with PDGF-BB/IGF-I as potential methods of promoting bone formation around dental implants. Nociti et al 17 also demonstrated a greater extension of bone-to-implant contact, a larger percentage of bone area, and greater intensity of bone labeling for immediate implants partially in contact with bone and treated with PDGF and IGF-1 when compared to controls. Hanisch et al 18 evaluated bone formation and reosseointegration following surgical implantation of recombinant human bone morphogenetic protein-2 (rhBMP-2) in peri-implantitis defects in monkeys.…”

“…The use of growth factors has also been reported to enhance bone healing around titanium implants. [16][17][18] Becker et al 16 evaluated bone promotion around implants inserted into fresh extraction sockets with large buccal dehiscences treated with expanded polytetrafluoroethylene (ePTFE) membranes alone or in combination with cortical demineralized freeze-dried bone (DFDBA) or with the combination of platelet derived growth factor-BB (PDGF) and insulin like growth factor-I (PDGF/IGF-I). After 18 weeks, a significant gain in clinical bone levels was present in both the ePTFE membrane alone group (P <0.005) and PTFE plus PDGF/IGF-I group (P <0.01), but not in the PTFE plus DFDBA group.…”

Growth Factors and Craniofacial Surgery

“…Moreover, it may have a significant impact on the expression of Osterix (Osx) and expression of Runx2. This dual relationship was confirmed in studies by Nociti et al 94 Furthermore, IGF-1 appears to upregulate type I collagen and alkaline phosphatase.…”

A Comparison Between Enamel Matrix Derivative and a Bioabsorbable Membrane to Enhance Healing Around Transmucosal Immediate Post‐Extraction Implants

“…The use of several growth factors such as platelet-derived growth factor (PDGF), insulin-like growth factor (IGF), and bone morphogenetic protein (BMP)-2 has been shown to enhance bone healing around dental implants. [31][32][33] Enamel matrix derivate is a mixture of proteins with amelogenin as a major component that has been demonstrated to promote periodontal regeneration with the formation of acellular cementum, collagen fibers, and alveolar bone both in vitro and in clinical studies. [20][21][22][23][24][25][26][27][28][29] In a randomized, controlled clinical trial on 33 subjects, Heijl et al 34 demonstrated that the sites treated with EMD showed an increased gain of radiographic bone and clinical attachment compared to control sites at 3 years after surgery.…”