Histology Proved Malpositioning of Dextranomer/Hyaluronic Acid in Submucosal Ureter in Patients After Failed Endoscopic Treatment of Vesicoureteral Reflux

Ben‐Meir, David; Morgenstern, Sara; Sivan, Bezalel; Efrat, Rachel; Livne, Pinhas M.

doi:10.1016/j.juro.2012.03.019

Cited by 8 publications

(2 citation statements)

References 7 publications

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“…There was no a significant difference in the amount of cytokines between the patients with primary VUR and patients with primary VUR following failed injection therapy with Dx/HA. The mean VEGF and CD34 scores were 5.7±15.1 (0-80) cells per HPF and 9.6±3.5 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21) vessels per HPF in ureters with reflux with primary VUR respectively; and these values were 16.2±23.6(0-90) cells per HPF and 10.2±3.5(4-16) vessels per HPF in ureters with reflux had history of failed dextranomer/hyaluronic-acid(Dx/HA) injections these values were 60.6±16.4(32-84) cells per HPF and 17.8±4.1 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) vessels per HPF in the control group. The amount of VEGF and CD34 were same both of the patients with primary VUR and patients with primary VUR following failed injection therapy with Dx/HA.…”

Section: Immunohistochemistrymentioning

confidence: 99%

“…In the literature, similar histological findings were reported by other studies as previously discussed. [23][24] Schwentner et al 25 VEGF, which is a stimulator in vasculogenesis is a signal protein produced by muscle or endothelial cells to protect the tissue under conditions of stress, including hypoxia and ischemia. Additionally, it is important for regulating tissue growth, nerve coordination and gap junction metabolism.…”

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Primer Vezikoüreteral Reflülü (VUR) ve Dx/HA ile Başarısız Enjeksiyon Tedavisi Sonrası Primer VUR lu Çocukların Üreterovezikal Bileşkesinde Sitokin Profillerinin ve Ultrayapısal Değişikliklerinin Karşılaştırılması.

Deger¹,

İzol²,

Kuyucu³

et al. 2020

jocass

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Purpose: To compare the cytokine profiles and ultrastructural changes in the ureterovesical junctions of children with primary vesicoureteral reflux(VUR) and children with primary VUR following failed injection therapy with dextranomer/hyaluronic-acid (Dx/HA) using immunohistochemical methods and transmission electron microscopy (TEM).Materials and Methods: 41 children underwent ureteroneocystostomy for VUR and 18 children underwent ureteroneocystostomy for primary VUR following failed injection therapy with Dx/HA. Sixty-seven distal intravesical ureters were obtained during surgery for histopathological and ultrastructural evaluations. The ureteral wall smooth-muscle organization and transforming growth factor-β1(TGF-β1), vascular endothelial growth factor(VEGF), and CD34 were evaluated immunohistochemically. The ultrastructural evaluations and morphological descriptions were performed semi-quantitatively.Results: Of the patients, 10(24,3%) were male and 31(75,7%) were female. 28 ureter had a history of failed Dx/HA injections.Histopathology; the amount of TGF-β1, and the VEGF and CD34 levels were same in the patients with primary VUR and patients with primary VUR following failed injection therapy with Dx/HA but different compared with the control group(p=0.001,p<0.001, and p<0.001, respectively), but the differences were not correlated with the grade of reflux(p=0.42, p=0.26 and p=0.94 respectively).Ultrastructural changes in the muscle cells were observed in all the VUR specimens.Conclusions: Our study demonstrated that ultra-structural changes in the muscle cells were observed in all VUR specimens. There was no significant difference in the quantification of cytokine assays between the patients with primary VUR and primary VUR with failed Dx/HA therapy. The quantification of VEGF, CD34, and, TGF-β1 levels was comparable in both primary VUR groups.

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