Histology of Intervertebral Disc Protrusion

Kuga, Naoyuki; Kawabuchi, Masaru

doi:10.1097/00007632-200109010-00005

Cited by 21 publications

References 18 publications

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Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments

et al. 2006

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The unique biochemical composition and structure of the intervertebral disc allow it to support load, permit motion, and dissipate energy. With degeneration, both the biochemical composition and mechanical behavior of the disc are drastically altered, yet quantitative relationships between the biochemical changes and overall motion segment mechanics are lacking. The objective of this study was to determine the contribution of nucleus pulposus glycosaminoglycan content, which decreases with degeneration, to mechanical function of a rat lumbar spine motion segment in axial loading. Motion segments were treated with varying doses of Chondroitinase-ABC (to degrade glycosaminoglycans) and loaded in axial cyclic compression-tension, followed by compressive creep. Nucleus glycosaminoglycan content was significantly correlated ( p < 0.05) with neutral zone mechanical behavior, which occurs in low load transition between tension and compression (stiffness: r ¼ 0.59; displacement: r ¼ À0.59), and with creep behavior (viscous parameter h 1 : r ¼ 0.34; short time constant t 1 : r ¼ 0.46). These results indicate that moderate decreases in nucleus glycosaminoglycan content consistent with early human degeneration affect overall mechanical function of the disc. These decreases may expose the disc to altered internal stress and strain patterns, thus contributing through mechanical or biological mechanisms to the degenerative cascade. ß

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Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments

et al. 2006

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Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc

et al. 2022

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Intervertebral disc degeneration is a common cause of low back pain, the leading cause of disability worldwide. Appropriate preclinical models for intervertebral disc research are essential to achieving a better understanding of underlying pathophysiology and for the development, evaluation, and translation of more effective treatments. To this end, in vivo animal and ex vivo organ culture models are both widely used by spine researchers; however, the relative strengths and weaknesses of these two approaches are a source of ongoing controversy. In this article, members from the Spine and Preclinical Models Sections of the Orthopedic Research Society, including experts in both basic and translational spine research, present contrasting arguments in support of in vivo animal models versus ex vivo organ culture models for studies of the disc, supported by a comprehensive review of the relevant literature.The objective is to provide a deeper understanding of the respective advantages and limitations of these approaches, and advance the field toward a consensus with Shirley N. Tang and Andres F. Bonilla contributed equally to this study.

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Disc Herniation and Radiculopathy

Earls

Kiefer

2019

Spine Pain Care

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Histology of Intervertebral Disc Protrusion

Abstract: The results from this study indicate that disc protrusion can be caused by disorganization of the ruptured annular lamellae, not by focal compression of the nucleus pulposus.

Cited by 21 publications

References 18 publications

Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments

Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments

Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc

Disc Herniation and Radiculopathy

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