Histology of Healing Split-Thickness, Full-Thickness Autogenous Skin Grafts and Donor Sites

Hinshaw, J. Raymond

doi:10.1001/archsurg.1965.01320160112027

Cited by 82 publications

(33 citation statements)

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“…In 1965, Hinshaw and Miller published an extensive report on the healing of 7 × 7-cm full-thickness surgically excised wounds in young Chester White pigs (10 kg) that were covered with a 30/1000-inch split-thickness or full-thickness autograft. 21 By the end of a 6-week study period, the wounds were healed and mostly devoid of hair, and had become level with or slightly raised above the surrounding normal skin. Mittermayr et al grafted 8 × 4-cm full-thickness wounds with split-thickness (0.4 mm) skin grafts fixed with or without fibrin sealant.…”

Section: Discussionmentioning

confidence: 98%

Early versus Delayed Excision and Grafting of Full-Thickness Burns in a Porcine Model: A Randomized Study

Singer

Toussaint

Chung

et al. 2016

Plastic &Amp; Reconstructive Surgery

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Section: Discussionmentioning

confidence: 98%

Early versus Delayed Excision and Grafting of Full-Thickness Burns in a Porcine Model: A Randomized Study

Singer

Toussaint

Chung

et al. 2016

Plastic &Amp; Reconstructive Surgery

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“…However, Maclaren et al reported on one patient with a graft perfused from its periphery by blood entering horizontally through a contact point with the surrounding macular choroid as estimated by high speed angiography [20]. This is plausible, as in skin grafts the major contribution to revascularization of the graft originates from the underlying bed, and also, but less often, from the graft margins [6,14].…”

Section: Discussionmentioning

confidence: 99%

Retinal pigment epithelium and choroid translocation in patients with exudative age-related macular degeneration: long-term results

Maaijwee

Heimann

Missotten

et al. 2007

Graefes Arch Clin Exp Ophthalmol

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Background To study the results of the translocation of a free autologous retinal pigment epithelium (RPE)-choroid graft after removal of a subfoveal choroidal neovascular membrane in patients with exudative age-related macular degeneration (AMD), and to determine whether preoperative variables may predict visual outcome at 1 year after surgery. Methods Prospective interventional case series of 84 eyes of 83 consecutive eligible patients with exudative AMD with a minimal follow-up of 1 year after surgery. Of this group, 45, 24 and 11 patients reached a follow-up of respectively 2, 3 and 4 years. Pre-and postoperative evaluation included ETDRS visual acuity (VA), fixation testing and color fundus photography. Preoperative fluorescein angiograms were assessed by masked readers for lesion size, size of hemorrhage and lesion composition according to the MPS criteria. The relationship between lesion composition adjusted for preoperative delay and VA, lesion size, percentage of blood, and visual outcome at 1 year after surgery was analyzed. Results The mean VA (logMAR) improved slightly at 1 and 2 years (0.89, Δ=−0.06), 3 years (0.79, Δ=−0.16) and 4 years (0.74, Δ=−0.21) after surgery. Five patients had a preoperative VA better than 20/80, compared to 19 out of 84, six out of 45, four out of 24 and two out of 11 after 1, 2, 3 and 4 years respectively. Fixation was located on the graft in 62 patients (74%) up to the last examination. Predominantly classic and occult lesions had a significant better prognosis than minimally classic or hemorrhagic (≥50% blood) lesions. Retinal detachment occurred in seven patients; two caused by rhegmatogenous detachment and five caused by proliferative vitreoretinopathy. In 11 eyes, a recurrent or persisting neovascular membrane was observed. Conclusion An autologous free RPE-choroid graft may stabilize or improve vision in patients with exudative AMD up to 4 years after surgery.

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“…extracellular matrix (ECM), and differentiation of fibroblasts into myofibroblasts (Desmouli+re et al, 1992; Gabbiani et al, 1971; Hinshaw et al, 1965). The processes of cellular differentiation, dermal tissue degradation, synthesis, and remodeling are guided by cytokines, cell-cell contacts and cell-matrix interactions (Grinnell, 1994;Tooney et al, 1993;Ruoslahti, 1989).…”

Section: Histocbem Cytochem 44:1311-1322 19%)mentioning

confidence: 99%

Extracellular matrix characterization during healing of full-thickness wounds treated with a collagen/elastin dermal substitute shows improved skin regeneration in pigs.

Lamme¹,

Vries²,

Veen³

et al. 1996

J Histochem Cytochem.

134

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We investigated the architecture of the extracellular matrix (ECM) during healing of full-thickness wounds in the pig. Two different treatments, one based on epidermal transplantation (split skin mesh grafts, SP wounds) and one consisting of a combination of epidermal transplantation and a dermal matrix substitute (MA wounds) were compared. The dermal matrix consisted of native bovine collagen coated with elastin hydrolysate. The latter treatment r e d u d wound contraction and improved tissue regeneration. The expression patterns of fibronectin, von Willebrand factor, laminin, chondroitin sulfate, and elastin, detected by immunohistochemistry, were examined in time and indicated different stages of healing. During the early phase of healing the dermal matrix induced more granulation tissue, a *rent fibronectin expression pattem, and rapid vascular cell ingrowth (von Willebrand factor). Furthermore, in the MA wounds chondroitin sulfate was detected earlier in the basement membrane and fibronectin staining disappeared more

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Histology of Healing Split-Thickness, Full-Thickness Autogenous Skin Grafts and Donor Sites

Cited by 82 publications

References 1 publication

Early versus Delayed Excision and Grafting of Full-Thickness Burns in a Porcine Model: A Randomized Study

Early versus Delayed Excision and Grafting of Full-Thickness Burns in a Porcine Model: A Randomized Study

Retinal pigment epithelium and choroid translocation in patients with exudative age-related macular degeneration: long-term results

Extracellular matrix characterization during healing of full-thickness wounds treated with a collagen/elastin dermal substitute shows improved skin regeneration in pigs.

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