Histology of Chemically Induced Mesotheliomas in Mrc-wistar Rats

Pelfrène, Alain F.; Astiazarán-García, Humberto

doi:10.1177/030089167506100602

Cited by 17 publications

(3 citation statements)

References 12 publications

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“…of primary mesotheliomas in Fischer 344 rats were similar to those of asbestos-induced mesotheliomas in this species. Our detailed histologic and electron microscopic findings of the tumors, as those of others (4,13,20,24,29), were quite similar to those induced by asbestos. These results indicate that morphological characteristics of mesotheliomas are the same, irrespective of whether the tumors are induced or spontaneous.…”

Section: Discussionsupporting

confidence: 85%

Spontaneous Mesotheliomas in Fischer Rats—A Histological and Electron Microscopic Study

1987

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A E S T R A~Seventeen mesotheliomas from 395 untreated male Fischer 344/DuCrj rats were studied by light and electron microscopy to define the morphological characteristics of the tumors. In 16 out of 17 rats, mesotheliomas were observed in the abdominal and/or scrota1 sac, and the other one was localized on the pleura. Grossly, tumors were yellow-brown with various-sized multiple modules growing irregularly over the surface of the serosa. Microscopically, they varied from complex papillary to sessile nodular growths. Tumor cells were cuboidal to polygonal with round to oval nuclei, and were sometimes arranged in tubule-like structures. Occasionally, the cells contained Mowry's colloidal iron positive materials, which were negative following prior incubation with hyaluronidase. Furthermore, intracellular keratins were detected using the peroxidaseantiperoxidase method. Ultrastructural features of tumor cells included numerous microvilli, a basement membrane, junctional complexes, abundant cytofilaments, dilated rough surfaced endoplasmic reticulum cisternae, and a well-developed Golgi apparatus. The morphological characteristics of these tumors in Fischer 344 rats were consistent with those in humans and with experimentally induced counterparts in rats. The histogenesis of these tumors and the variability in their incidence following oral administration of chemical carcinogens is discussed.

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Section: Discussionsupporting

confidence: 85%

Spontaneous Mesotheliomas in Fischer Rats—A Histological and Electron Microscopic Study

1987

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“…These include malignant uterine mesotheliomas in squirrel monkeys after prolonged treatment with diethylstilbestrol (29) and peritoneal mesothelioma in rats following the administration of 1-nitroso-5,6dihydrouracil (30). A number of nonfibrous chemicals other than asbestos and the fibrous nonasbestos materials (see below) have been found to produce mesotheliomas experimentally.…”

Section: Several Case Reports Have Attributed a Mesothelioma To Radiamentioning

confidence: 99%

Mesothelioma in Man and Experimental Animals

Kannerstein¹,

Churg²

1980

Environmental Health Perspectives

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. The National Institute of Environmental Health Sciences (NIEHS) and Brogan & Partners are collaborating with JSTOR to digitize, preserve and extend access to Environmental Health Perspectives.Asbestos has been established as the cause of most cases of diffuse malignant mesothelioma occurring in the industrialized world. The morphology of mesothelioma may be complex, and the employment of dnicl, histochemical and ultrastructural studies are often helpful in identification. Diagnostic dhifcultiesmay to some degree blur the extent of its prevalence and reliance on exposure history may not reveal its association with asbestos. Reference panels can be useful in assessing the former and analysis of lung tissue asbestos content may help to clarify the latter, especially in the low dose range. Electron microscopy may prove to be of assistance in this respect, possibly with particular attention to the peripheral areas of the lung. Anhnal experimentation has supported epidemiologic conclusions and revealed the phenomenon of fiber carcinogenesis. The morphology of mesothelioma in experimental animals is very similar to that in humans, Eliuding ultrastructural and biochemical features.The predominant association of mesothelioma with exposure to asbestos and the failure to demonstrate another epidemiologically consequential etiologic agent, in the industrialized world, give this tumor unique significance (1). Other neoplasms of increased prevalence among asbestos workers have one or more known or suspected causal factors that act upon the general population (2). The one known exception to the singular role of asbestos in relation to mesothelioma is confined to an area of Turkey. Here endemic mesothelioma has been related to zeolites. These resemble asbestos, in that they are fibrous hydrated silicates but differ chemically and structurally (3).The term, mesothelioma, used in the context of asbestos exposure in man means diffuse malignant mesothelioma of the pleura and peritoneum. The localized, usually benign, primary tumors of the pleura and the very rare malignant mesotheliomas of the pericardium and tunica vaginalis have not been shown to have any association with asbestos.A brief summary of features of the morphology of human diffuse malignant mesothelioma may be desirable. The term diffuse is significant. Although possibly limited in its earliest phases, when meso-

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“…A number of nonfibrous chemicals other than asbestos and the fibrous nonasbestos materials (see below) have been found to produce mesotheliomas experimentally. These include malignant uterine mesotheliomas in squirrel monkeys after prolonged treatment with diethylstilbestrol (29) and peritoneal mesothelioma in rats following the administration of 1-nitroso-5,6-dihydrouracil (30). A metabolite of molds, sterigmatocystin, injected into the peritoneal cavity of rats, caused mesotheliomas (31).…”

mentioning

confidence: 99%

Mesothelioma in man and experimental animals.

Kannerstein¹,

Churg²

1980

Environ Health Perspect

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Asbestos has been established as the cause of most cases of diffuse malignant mesothelioma occurring in the industrialized world. The morphology of mesothelioma may be complex, and the employment of chemical, histochemical and ultrastructural studies are often helpful in identification. Diagnostic difficulties may to some degree blur the extent of its prevalence and reliance on exposure history may not reveal its association with asbestos. Reference panels can be useful in assessing the former and analysis of lung tissue asbestos content may help to clarify the latter, especially in the low dose range. Electron microscopy may prove to be of assistance in this respect, possibly with particular attention to the peripheral areas of the lung. Animal experimentation has supported epidemiologic conclusions and revealed the phenomenon of fiber carcinogenesis. The morphology of mesothelioma in experimental animals is very similar to that in humans, including ultrastructural and biochemical features.

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Histology of Chemically Induced Mesotheliomas in Mrc-wistar Rats

Cited by 17 publications

References 12 publications

Spontaneous Mesotheliomas in Fischer Rats—A Histological and Electron Microscopic Study

Spontaneous Mesotheliomas in Fischer Rats—A Histological and Electron Microscopic Study

Mesothelioma in Man and Experimental Animals

Mesothelioma in man and experimental animals.

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