Histology as Prognostic Factor in Early-Stage Cervical Carcinoma. Experience in a Third-Level Institution

Barquet-Muñoz, Salim Abraham; Cruz-Rodríguez, Efraín; León, David F. Cantú de; Isla‐Ortiz, David; Montalvo-Esquivel, Gonzalo; Herrera-Montalvo, Luis Alonso; Pérez‐Plasencia, Carlos; Pérez-Montiel, Delia; Herrera‐Gómez, Ángel

doi:10.24875/ric.17002143

Cited by 4 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The number of SCC is greater in the ART group compared to the RH group, whereas that of AC was greater in the RH group. Whether or not non-SCC histology in early stage cervical cancer is associated with a poor prognosis is unclear; some researchers have reported that oncologic outcomes did not differ between common histological types during early stage cervical cancer (18,20,22). Considering the subset of patients with tumors of SCC Histology, ART shows similar oncological outcomes to RH in this study.…”

Section: Discussionsupporting

confidence: 51%

Oncological and Reproductive Outcomes of Abdominal Radical Trachelectomy

et al. 2020

View full text Add to dashboard Cite

Background/Aim: There is an increasing demand for preserving the fertility of young women impacted with early-stage cervical cancer. The aim of this study is to evaluate the oncological and reproductive outcomes of abdominal radical trachelectomy (ART). Patients and Methods: We retrospectively reviewed patients with FIGO stageIA2-IB1 cervical cancer who underwent ART from 2007 to 2018. We also compared the oncological prognosis between the patients who underwent ART and radical hysterectomy (RH). Results: A total of 42 patients underwent ART. During median follow-up 62.5 months, there were 4 (9.5%) recurrences and 1 (2.4%) death. As for tumors ≤2 cm, the 5-year recurrence-free survival (RFS) rate and overall survival (OS) rate for patients who underwent ART was similar to those who underwent RH (89.8% vs. 92.7%, p=0.42 and 97.3% vs. 95.0%, p=0.44, respectively). Nineteen patients attempted to conceive and seven of them were successful. There was one case of a first-trimester miscarriage, two cases of preterm delivery, three cases of full-term delivery and one ongoing pregnancy. Conclusion: ART could be a feasible alternative to RH for patients with tumors ≤2 cm with comparable oncological outcome.

show abstract

Section: Discussionsupporting

confidence: 51%

Oncological and Reproductive Outcomes of Abdominal Radical Trachelectomy

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Previous studies have concluded that adenosquamous carcinoma of the cervix has a high degree of malignancy and a poor prognosis. 20,21 Prompt treatments in the early stages are expected to improve the prognosis of patients; Multicollinearity test and cox proportional hazard regression models were used for analysis. Proportional hazard assumption was tested and showed no interaction with time.…”

Section: Discussionmentioning

confidence: 99%

“…Adenosquamous carcinoma of the uterine cervix is a rare cervical cancer, with only a few cases reported. Previous studies have concluded that adenosquamous carcinoma of the cervix has a high degree of malignancy and a poor prognosis 20,21 . Prompt treatments in the early stages are expected to improve the prognosis of patients; however, the treatment principles are currently based on the guidelines for squamous cell carcinoma of the uterine cervix.…”

Section: Discussionmentioning

confidence: 99%

Comparison between laparoscopic and abdominal radical hysterectomy for cervical adenosquamous carcinoma at stage IA2 to IIA2: A multicenter retrospective study

Teng

Kang

et al. 2023

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Objective We aimed to compare the 5‐year oncological outcomes of laparoscopic/abdominal radical hysterectomy (LRH/ARH) in patients with cervical adenosquamous carcinoma at stage IA2 to IIA2 based on the 2009 or 2018 International Federation of Gynecology and Obstetrics (FIGO) staging criteria. Methods Based on the clinical diagnosis and treatment of cervical cancer in China (Four C) database, Cox risk regression models were applied to analyze tumor prognosis treated with ARH/LRH in FIGO 2009 and 2018 IA2‐IIA2 patients and stratified findings according to tumor diameter (≤4 and >4 cm subgroups). And to avoid bias, propensity score matching (PSM) was also used for the cohort study. Results Based on FIGO 2009 staging criteria (n = 474), there was no significant difference between the ARH and LRH groups in 5‐year disease‐free survival (DFS) or overall survival (OS). Lymph node metastasis was a risk factor for 5‐year DFS in this stage. After PSM, lymphovascular space invasion (LVSI) was an independent risk factor for 5‐year OS in the tumors ≤4 cm subgroup. Based on FIGO2018 staging criteria (n = 322), cervical interstitial infiltration depth was an independent risk factor for 5‐year OS in the total population and the tumor diameter ≤4 cm subgroup. Conclusions Laparoscopic surgery was not a risk factor affecting the oncologic prognosis of adenosquamous carcinoma of the cervix based on either FIGO 2009 or 2018 staging of stage IA2‐IIA2. In addition, LRH may be considered for patients with early‐stage cervical adenosquamous carcinoma.

show abstract

“…Many studies have investigated the survival and prognostic significance of patients with early-stage ASC and cervical adenocarcinoma. We summarized some of these in Table 4, showing 65.8% to 100% of 5-year OS rates and 55.1% to 92.3% of 5-year DFS rates [ 2 , 11 , 19 – 21 ]. Our study showed that the median OS was 74 months, and the 3-and 5-year OS rates were 82% and 71.4%, respectively.…”

Section: Discussionmentioning

confidence: 99%

The best postoperative adjuvant therapy for patients with early stage cervical adenosquamous carcinoma

Liu

Zhang

et al. 2022

BMC Women's Health

View full text Add to dashboard Cite

Background Cervical adenosquamous carcinoma (ASC) was previously thought to be a subtype of cervical adenocarcinoma, but recent studies have found that the clinical features of the two diseases are different. Moreover, the pathological characteristics, survival, prognosis, and optimal ASC therapy remain unknown. This study aims to retrospectively analyze the postoperative survival of patients with early-stage ASC and to evaluate their condition after treatment with postoperative concurrent chemoradiotherapy (CCRT) and prophylactic irradiation of the para-aortic lymphatic drainage area. Methods This study enrolled 131 patients with pathologically confirmed ASC screened from 3502 patients with confirmed stage I–II cervical cancer diagnosis who had completed surgical treatments in our hospital. Among the 131 enrolled patients, 75 patients received CCRT, 33 patients received chemotherapy (CT), and 23 patients did not receive adjuvant treatment (named surgery alone (S alone). Of the 75 patients CCRT, 43 patients received prophylactic irradiation of the para-aortic lymphatic drainage area. The efficacy of the postoperative treatments of patients among groups (CCRT, CT, and S alone) was compared. Results The median follow-up time, age, and overall survival (OS) were 76 months, 43 years, and 74 months, respectively. The 3- and 5-year survival rates were 82% and 71.4%, respectively. The median disease-free survival (DFS) was 64 months. Cox regression analysis showed that postoperative adjuvant treatment modalities and positive lymph node metastases were associated with OS and DFS. Patients who received CCRT treatment had higher OS and DFS than those with CT and S alone. Prophylactic irradiation of the para-aortic lymphatic drainage area did not improve the OS and DFS of patients with CCRT treatment. However, further subgroup analysis suggested that it might improve survival rates in patients who had positive pelvic lymph nodes as confirmed by postoperative pathology. Conclusion Postoperative CCRT improved the survival rates in patients with early-stage ASC. The value of prophylactic irradiation of the para-aortic lymphatic drainage area remains debatable, but it may benefit patients with pelvic lymph node involvement.

show abstract

Histology as Prognostic Factor in Early-Stage Cervical Carcinoma. Experience in a Third-Level Institution

Cited by 4 publications

References 11 publications

Oncological and Reproductive Outcomes of Abdominal Radical Trachelectomy

Oncological and Reproductive Outcomes of Abdominal Radical Trachelectomy

Comparison between laparoscopic and abdominal radical hysterectomy for cervical adenosquamous carcinoma at stage IA2 to IIA2: A multicenter retrospective study

The best postoperative adjuvant therapy for patients with early stage cervical adenosquamous carcinoma

Contact Info

Product

Resources

About