Histology as a diagnostic tool for intestinal isosporiasis in immunocompromised patients

Rao, Anjali; Vasudevan, Geetha; Kudva, Ranjini; Vidhyalakshmi, S; Rupashree, S

doi:10.1016/s2222-1808(12)60055-3

Cited by 7 publications

(9 citation statements)

References 5 publications

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“…Fragmentary information on endogenous stages have been obtained by examination of human biopsy tissues from the small intestine (Table 3) (Niedmann, 1963; French et al ., 1964; Brandborg et al ., 1970; Henry et al ., 1974; Trier et al ., 1974; Liebman et al ., 1980; Veldhuyzen van Zanten et al ., 1984; Modigliani et al ., 1985; Restrepo et al ., 1987; Peng and Tsai, 1991; Benator et al ., 1994; Comin and Santucci, 1994; Michiels et al ., 1994; Hamour et al ., 1997; Bialek et al ., 2001; Field, 2002; Jongwutiwes et al ., 2002; Sasaki et al ., 2004; Murphy et al ., 2011; Rao et al ., 2012; Kim et al ., 2013; Agholi et al ., 2016 b ; Swanson et al ., 2018) and bile ducts/or gallbladder (Benator et al ., 1994; Frenkel et al ., 2003; Lagrange-Xélot et al ., 2008; Walther and Topazian, 2009; Agholi et al ., 2016 a ).…”

Section: Morphology and Life Cyclementioning

confidence: 99%

“…Immunosuppressed patients infected with C. belli have been reported in association with viral infections other than HIV, such as Human T-cell Leukaemia Virus type 1 (HTLV-1) (Greenberg et al ., 1988; Peng and Tsai, 1991; Ud Din et al ., 2012; Hasan et al ., 2017). The parasite has also been reported for several individuals with cancers such as Hodgkin's lymphoma (Brandborg et al ., 1970; Peng and Tsai, 1991; Resiere et al ., 2003; Lagrange-Xélot et al ., 2008), mediastinal thymoma (Meamar et al ., 2009), malignant lymphoma (Ohtaki et al ., 1976), acute leukaemia (Morakote et al ., 1987; Jayshree et al ., 1996; Ud Din et al ., 2012), hypogammaglobulinemia (Desai et al ., 2014), or after organ transplant (bone marrow, intestine, liver, renal or cardiac) (Bialek et al ., 2002; Yazar et al ., 2006; Atambay et al ., 2007; Koru et al ., 2007; Gruz et al ., 2010; Rao et al ., 2012; Usluca et al ., 2012; Marathe and Parikh, 2013; Sanches et al ., 2015; Yadav et al ., 2016; Akateh et al ., 2018). In some cases, a combination of several pathologies such as HTLV-1 positive with aggressive T-cell malignancy was observed in C. belli patients (Greenberg et al ., 1988; Peng and Tsai, 1991; Kawano et al ., 1992; Yamane et al ., 1993; Ud Din et al ., 2012; Hasan et al ., 2017).…”

Section: Clinical Symptomsmentioning

confidence: 99%

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Cystoisospora belliinfections in humans: the past 100 years

Dubey

Almerı́a

2019

Parasitology

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Cystoisospora belli is a coccidian parasite of humans, with a direct fecal–oral transmission cycle. It is globally distributed, but mainly found in tropical and subtropical areas. Many cases of C. belli infections have been reported in patients with HIV, and in patients undergoing immunosuppressive therapy for organ transplants or those treated for tumours worldwide. Unsporulated or partially sporulated oocysts of C. belli are excreted in feces. When sporulated oocysts in contaminated water or food are ingested, asexual and sexual stages of C. belli are confined to the epithelium of intestines, bile ducts and gallbladder. Monozoic tissue cysts are present in extra-intestinal organs (lamina propria of the small and large intestine, lymph nodes, spleen, and liver) of immunosuppressed humans. However, a paratenic host has not been demonstrated. Cystoisospora belli infections can be persistent, lasting for months, and relapses are common; the mechanism of relapse is unknown. Recently, the endogenous stages of C. belli were re-examined and attention was drawn to cases of misidentification of non-protozoal structures in the gallbladder of patients as C. belli. Here, we review all aspects of the biology of C. belli, including morphology, endogenous stages, prevalence, epidemiology, symptoms, diagnosis and control.

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Section: Morphology and Life Cyclementioning

confidence: 99%

Section: Clinical Symptomsmentioning

confidence: 99%

Cystoisospora belliinfections in humans: the past 100 years

Dubey

Almerı́a

2019

Parasitology

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“…On H&E staining, oval-shaped intracellular structures, measuring approximately 20 µ m, were identified within the cytoplasm of the biliary epithelium, consistent with C. belli . ( Figure 1 ) The background gallbladder was otherwise unremarkable [ 27 , 30 , 31 ]. The organisms were highlighted by the PAS/D special stain.…”

Section: Case Reportmentioning

confidence: 99%

Cystoisospora belli Gallbladder Infection in a Liver Transplant Donor

Akateh

Arnold

Benissan-Messan

et al. 2018

Case Reports in Infectious Diseases

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Introduction Cystoisospora belli (previously Isospora belli) is a parasitic protozoan of the human gastrointestinal system. It rarely causes symptoms in immunocompetent hosts but can cause severe diarrhea in immunocompromised patients, with a rate of recurrence and risk of dissemination. Gallbladder infections are however rare. The treatment of choice for symptomatic patients is a 7–10-day course of trimethoprim-sulfamethoxazole. Case In this case, we report on an incidental finding of Cystoisospora belli organisms in the donor gallbladder following a transplant cholecystectomy. There was no report of symptoms in the donor. The recipient was treated with a course of trimethoprim-sulfamethoxazole, without evidence of cystoisosporiasis. Given the risk of recurrence in immunocompromised hosts, the patient will continue to be monitored for reactivation in the future. Conclusion Despite advances in transplant protocols and screening, disease transmission from the donor to recipient still occurs in about 0.2% of all organ transplants. With the increased use of organs from drug overdose victims and other high-risk donors, practitioners (including pathologists, hepatologists, and surgeons) must maintain a high index of suspicion for such potentially harmful organisms.

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“…En el caso de Cryptosporidium, teniendo en cuenta su tamaño (3-6 µm), fue necesaria la tinción para realizar una adecuada búsqueda de los ooquistes. En cuanto al método de concentración utilizado (Ritchie modificado/formol éter), es de sedimentación útil, tanto en la concentración de protozoos como de helmintos; para estos últimos se prefieren los métodos de flotación, teniendo en cuenta el tamaño de los huevos de estos parásitos [17][18][19][20].…”

Section: Recolección De La Informaciónunclassified

Prevalencia de parasitosis intestinal, anemia y desnutrición en niños de un resguardo indígena Nasa, Cauca, Colombia, 2015

Gaviria

Soscue

Campo-Polanco

et al. 2017

Rev. Fac. Nac. Salud Pública

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Objective: to determine the prevalence of intestinal parasitosis, anemia and malnutrition among children of a Nasa indigenous reservation from Caldono in the Colombian department of Cauca, and their distribution according to clinical, sociodemographic and healthcareinfrastructure variables. Methodology: a crosssectional study with a primary source of information. Sixtytwo children were evaluated for intestinal parasites via stool analysis. Similarly, anthropometric measurements were used to assess nutritional status and determine the prevalence of various types of malnutrition. Likewise, the presence of anemia was determined by measuring hemoglobin levels. The group was described using summary measures for age and frequency measures for the other variables. Prevalence was calculated for intestinal parasites, anemia and malnutrition, and its association with independent variables was explored using hypothesis testing. The program SPSS 22.0 was used in this study. Results:

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Histology as a diagnostic tool for intestinal isosporiasis in immunocompromised patients

Cited by 7 publications

References 5 publications

Cystoisospora belliinfections in humans: the past 100 years

Cystoisospora belliinfections in humans: the past 100 years

Cystoisospora belli Gallbladder Infection in a Liver Transplant Donor

Prevalencia de parasitosis intestinal, anemia y desnutrición en niños de un resguardo indígena Nasa, Cauca, Colombia, 2015

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