Histologische Veränderungen des respiratorischen Schleimhautepithels der unteren Nasenmuscheln nach Argon-Laserstrichkarbonisation (Laser-Muschel-Kaustik) bei Rhinopathia vasomotorica

Lenz, H; Preussler, H

doi:10.1055/s-2007-1008010

Cited by 16 publications

(4 citation statements)

References 3 publications

(3 reference statements)

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“…While recovery of pseudostratified epithelium usually requires 1 year or more (Dixon et al 1949;Barton et al 1980;Gray et al 1980;Inouye et al 1999) nothing is known about the transformation rate leading from pseudostratified ciliated epithelium to squamous metaplasia. Lenz and Preußler (1986) found stratified squamous epithelium 2 to 8 months after laser surgery of the inferior turbinate, whereas recovery of pseudostratified ciliated epithelium was found 1 to 2 1/ 2 years following surgery.…”

Section: Epithelial Transformation and Recoverymentioning

confidence: 89%

Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate

Schrödter

Biermann

Halata

2003

Anatomy and Embryology

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Though the lining of the healthy human nose is subject of numerous investigations, age-related changes have attracted little attention. Furthermore, varying sampling sites complicate the evaluation of the available information. Reference is needed for evaluation of abnormal conditions, e.g. in persons with sleep apnea. Biopsy samples from the middle turbinate of 40 healthy humans aged 5 to 75 years were examined. Tissue samples were fixed immediately in glutaraldehyde and embedded in Epon for semi-thin sectioning and blind histological evaluation. In all age groups, patchy arrangement of different epithelial types were found. Ciliated epithelium decrease with age. Stratified and atrophic epithelial types show striking changes. Thin atrophic epithelium with conspicuously thickened basement membranes is only seen above the age of 40 years and is frequently found in older subjects. Stratified epithelial types initially increase with age, but decrease above 50 years. In the middle aged group (26 to 50 years) we found a remarkably high amount of squamous metaplasia, resulting in overall thicker epithelium becoming thinner in older subjects. In contrast, basement membranes are thinnest in the middle aged group. In conclusion, evaluating the histology of nasal respiratory epithelium must take pronounced age-related physiological changes into account.

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Section: Epithelial Transformation and Recoverymentioning

confidence: 89%

Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate

Schrödter

Biermann

Halata

2003

Anatomy and Embryology

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“…This indicates an epithelial regener ation from the mitotically active stratum basale in seg ment 3. Other authors similarly described a rapid epithe lial regeneration after laser damage in vascular endothe lium [6,7], corneal epithelium [8][9][10] or in epithelium of the nasal mucosa [11].…”

Section: Discussionmentioning

confidence: 99%

Light- and Electron-Microscopic Study of the Rat Esophagus following Intraluminal Argon Laser Irradiation

Stratmann

Schaarschmidt²,

Lehmann³

et al. 1991

Cells Tissues Organs

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36 rat esophagi were irradiated by argon laser via an applicator with circumferential light distribution. They were perfused with glutaraldehyde and studied by light and transmission electron microscopy immediately, 2 days and 14 days after irradiation. Immediately after irradiation the laser center showed destruction of the keratinized stratified squamous epithelium. The collagenous fibers of the connective tissue were altered; fibrocytes and fibroblasts were severely damaged, and the microvascular lumina were occluded. The smooth muscle tissue and skeletal muscle tissue showed myofilament defects and initial karyonecrosis. There was decreasing damage of both fiber types up to 4 mm from the laser center. After 2 days the morphology of the laser center was not different from that seen immediately after irradiation. At a distance of 2 mm a partly differentiated new epithelium emerged below the necrotic epithelium. An inflammatory reaction was found in the connective tissue. After 14 days the esophageal wall was replaced and the lumen was occluded by young granulation tissue in the former laser center. Peripherally the esophageal wall appeared almost normal. As the rat esophagus serves as a model for esophagotracheal fistulae in newborn children, our findings indicate that the argon laser should be capable of occluding these fistulae likewise.

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“…Die Wundheilung dauert je nach Ausmaû der überschüssigen Gewebevernichtung 3 ± 6 Wochen. Die laserinduzierte subepitheliale Fibrose ist erst nach einem Jahr vollständig abgeschlossen [21,22]. Über 80 % der Patienten zeigten nach Argon-Laser-Strichkarbonisation eine Verbesserung der Nasenatmung.…”

Section: Endonasale Laseranwendungenunclassified

“…Das Nd:YAG-Laserlicht verursacht in der Schleimhaut eine ausgeprägte Fibrosierung mit Atrophie der Schleimdrüsen und Verkleinerung des venösen Plexus [15,21,22]. Aufgrund der groûen Eindringtiefe der Nd:YAG-Laserstrahlung sind diese Veränderungen am Gewebe stärker ausgeprägt als beim Argon-bzw.…”

Section: Endonasale Laseranwendungenunclassified

3 Laser in der Rhinologie

2003

Laryngorhinootologie

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In der Rhinologie wurden bisher verschiedene Lasersysteme, wie Argon-, KTP-, Dioden-, Nd:YAG-, Ho:YAG-, Er:YAG-und CO 2 -Laser bei unterschiedlichen Erkrankungen eingesetzt. Die Vorteile der Lasertechnik im Bereich der Nase und Nasennebenhöhlen sind eine gute intraoperative Übersicht durch die deutlich verbesserte Hämostase, eine hohe Präzision bei der Gewebeabtragung, eine geringe Gewebetraumatisierung und hieraus resultierend eine geringe Ödemneigung sowie Abnahme der postoperativen Schmerzen. In vielen Fällen kann auf die Einlage einer Nasentamponade verzichtet werden. Die Kenntnis der biophysikalischen Wirkung des jeweiligen Lasersystems und die sorgfältige Indikationsstellung für eine bestimmte Erkrankung führen zu sehr guten Behandlungsergebnissen. So hat aus unserer Sicht die Lasertherapie einen festen Stellenwert in der Behandlung der Nasenmuschelhyperplasie, der rezidivierenden Epistaxis einschlieûlich des M. Osler, von Hämangiomen und vaskulären Malformationen, der Choanalatresie, von begrenzten benignen Veränderungen sowie des Rhinophyms. Die Anwendung in der Septum-und Nasennebenhöhlenchirurgie sowie der endonasalen Tränenwegschirurgie hingegen muss zur Zeit noch mit Zurückhaltung beurteilt werden. Schlüsselwörter Laser´Rhinologie´Nase´Nasennebenhöhlen Inhaltsverzeichnis 3.1Einleitung ± Lasersysteme in der Rhinologie ¼ 55

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Histologische Veränderungen des respiratorischen Schleimhautepithels der unteren Nasenmuscheln nach Argon-Laserstrichkarbonisation (Laser-Muschel-Kaustik) bei Rhinopathia vasomotorica

Cited by 16 publications

References 3 publications

Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate

Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate

Light- and Electron-Microscopic Study of the Rat Esophagus following Intraluminal Argon Laser Irradiation

3 Laser in der Rhinologie

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