“…Many of the cardinal pathological features of rabies virus infection were first described over about a 40-year period extending from the early 1870s to the early 1900s (Abba & Bormans, 1905;Babes, 1892;Benedikt, 1878;Gowers, 1877;Negri, 1903a;Negri, 1909;Nepveu, 1872;Pasteur, Chamberland, Roux, & Thuillier, 1881;Ramón y Cajal & Garcia, 1904;Schaffer, 1888;Van Gehuchten & Nelis, 1900). However, throughout the subsequent century, especially following the introduction of electron microscopy and immunohistochemistry, pathological studies have continued to provide key insights into our understanding of this dreaded disease.…”