Histologische Untersuchung eines Falles von Lyssa

Pathology

“…Many of the cardinal pathological features of rabies virus infection were first described over about a 40-year period extending from the early 1870s to the early 1900s (Abba & Bormans, 1905;Babes, 1892;Benedikt, 1878;Gowers, 1877;Negri, 1903a;Negri, 1909;Nepveu, 1872;Pasteur, Chamberland, Roux, & Thuillier, 1881;Ramón y Cajal & Garcia, 1904;Schaffer, 1888;Van Gehuchten & Nelis, 1900). However, throughout the subsequent century, especially following the introduction of electron microscopy and immunohistochemistry, pathological studies have continued to provide key insights into our understanding of this dreaded disease.…”

120 years of hippocampal Schaffer collaterals

“…This position provided the young doctor with the opportunity to learn the methods of histology, including the Golgi impregnation, which was known since 1873. Schaffer was only a 24‐year‐old medical student when he published his first scientific work on the histopathology of spinal cord lesions caused by rabies (Schaffer,1888). He assumed, correctly, that the rabies virus traveled from the bitten body part by way of peripheral nerves to the corresponding segments of the spinal cord, where the most severe cellular infiltration and necrosis could be found.…”

Károly Schaffer and his school: The birth of biological psychiatry in Hungary, 1890–1940

“…"I was able to examine the central nervous system of a woman who had died of rabies in our section, and -still as a fourth-year student -I got to publish my findings in the most distinguished German specialized journal, Archiv für Psychiatrie [und Nervenkrankheiten]." In 1888, Schaffer discovered that the clinical symptoms of rabies could be linked anatomically to central nervous lesions [32]. In a second article in 1890, he reported that the maximal damage to the spinal cord corresponded to the site of the bite, that the virus reaches the spinal cord from the bite wound along the path of the nerves, and that the virus creates the central nervous symptoms as it spreads up the spinal cord [34].…”

“…[Schaffer K, typescript autobiography, Manuscript Archives of Hungarian Academy of Sciences, Budapest, Deák B, trans.]. Since his parents were unable to finance this pastime, Schaffer realized that he would have to study medicine, although he felt no intrinsic interest in the subject, still less in psychiatry (later saying that hospital psychiatry offered absolutely no charms for him) [32]. On his own, he developed the knowledge of Latin that he needed for medical-school admission (given that medical students were usually admitted from the Gymnasium, not the Realschule), and in 1882 began his medical studies.…”