Histologische Befunde bei ?fortschreitender Atrophie des Irisstromas mit Lochbildung und Proliferation des Hornhautendothels?

H, Pau

doi:10.1007/bf00682355

Cited by 9 publications

(3 citation statements)

References 8 publications

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“…Nodules of the iris have not been reported with essential iris atrophy, although extension of corneal endothelium onto the surface of the iris does occur (PAU, 1965). The nodules of the iris which have been repeatedly described with neurofibromatosis (LISCH, 1935;WOLTER & BUTLER, 1963;WALTON & GRANT, 1968) suggest a similarity to the present cases.…”

Section: Discussionsupporting

confidence: 57%

A syndrome of iris nodules, ectopic descemet’s membrane, and unilateral glaucoma

Cogan

Reese

1969

Doc Ophthalmol

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In this report we wish to describe the clinical and histopathologic abnormalities in two patients who presented with unilateral glaucoma and pedunculated nodules, thought to be melanomas, arising in a sector of the iris. Pathologically both eyes showed nevus-like clusters on the iris covered by a hyaline layer (ectopic Descemet's membrane) extending from the posterior surface of the cornea. To our knowledge this syndrome has been referred to only once previously and that in a paper describing 'pseudomelanomas' of the iris by KLIEN (1941) whose second case was similar to our two. All three patients were adult women in whom the condition occurred idiopathically and unilaterally.We have no explanation for the pathogenesis of this syndrome but its recognition appears to be important since the pathologic abnormalities suggest a benign process while the clinical impression in our two cases indicated malignant melanomas requiring enucleation. KLIEN'S (1941) patient had an enucleation for advanced glaucoma and corneal ulceration. CASE REPORTSCase 1 S.S. (MEEI 144-75-80) Fifty-one year old woman who had noted a "film over the left eye" for one month. She denied any previous trouble with her eyes but had not had prior ophthalmic examination. When examined by an optometrist several years previously she had not been told of any unusual ocular abnormality. (The optometrist's records had been destroyed in the meantime.)Examination showed a normal right eye with an acuity of 20120 and an applanation tension of 16 mm.Hg. The left eye had an acuity of 20125 and a

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Section: Discussionsupporting

confidence: 57%

A syndrome of iris nodules, ectopic descemet’s membrane, and unilateral glaucoma

Cogan

Reese

1969

Doc Ophthalmol

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“…Lebensjahrzehnt manifestiert, dem Rieger-Syndrom zugehort, wird diskutiert; wahrend Pau (18,19,20,21) mehr die Unterschiede herausarbeitet, werden die ,,proliferativen Endotheiiopathien" von den meisten Autoren als Einheit betrachtet (1,27,29). Die dieser Gruppe eigene Spatmanifestation hat offenbar zur Voraussetzung, daB feingewebliche, zunächst kiinisch nicht manifeste Membranstorungen schon in der Aniage vorgegeben sind (13).…”

unclassified

Dysplasie des Limbus corneae, des mesodermalen Irislagers sowie des Kieferskelettes in einer Familie

Piper¹,

Schwinger²,

Domarus³

1985

Klin Monatsbl Augenheilkd

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Ten members of the family B./A. (belonging to two generations) who had dysplasia of the anterior mesodermal layer of the iris were examined. Several of them also had moderate microcornea. The shape of the skull was remarkable, with micrognathia, in some cases combined with mandibular prognathism and early loss of the teeth. Members of the older generation suffered from pannus, although only pingueculae had been present in youth and adolescence. The anomaly of the anterior part of the eye combined with "dysostosis maxillofacialis" (Peters and Hövels) may represent an abortive form of Rieger's syndrome. An aggressive pannus does not appear to have been described before in this syndrome or related diseases.

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“…(1979) nennen sie ,,proliferative Endothehiopathien mit Irisabnormalitäten". Tatsachlich wurden histologisch Endothelprohiferationen auf Trabekel und Iris einerseits auch bei essentieller Irisatrophie (1,5,7,11,12,18), andererseits beim Chandler-Syndrom (15) gefunden. Irisknötchen kommen auch bei progressiver Irisatrophie vor (19,20), allerdings handelt es sich dabei offenbar nicht urn Nävi wie beim Cogan-Reese-Syndrom.…”

unclassified

Zur Kenntnis des Cogan-Reese-Syndroms

Sturrock¹,

Guggenheim²

1982

Klin Monatsbl Augenheilkd

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The clinical, histological and ultrastructural findings in a case of Cogan-Reese syndrome (iris nevus) are presented. The typical iris nodules first appeared 14 years after a unilateral, juvenile, open-angle glaucoma was diagnosed. No lasting regulation of the intermittently elevated pressure was possible either medically or surgically. The failure of two filtering operations was due to the histologically verified endothelialization of the blebs. Endothelialization and deposition of Descemet's membrane on the anterior surface of the lens and on the zonule is described for the first time in this syndrome. The histological findings support the view that the peripheral anterior synechiae and iris nodules are secondary to the endothelialization. Hence the diagnosis of Cogan-Reese syndrome cannot be made until relatively late in the course of this disease. Cytological similarities between the proliferating endothelium in this case and in Chandler syndrome support the recent hypothesis that the Cogan-Reese syndrome belongs to the irido-corneal-endothelial group of syndromes.

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Histologische Befunde bei ?fortschreitender Atrophie des Irisstromas mit Lochbildung und Proliferation des Hornhautendothels?

Cited by 9 publications

References 8 publications

A syndrome of iris nodules, ectopic descemet’s membrane, and unilateral glaucoma

A syndrome of iris nodules, ectopic descemet’s membrane, and unilateral glaucoma

Dysplasie des Limbus corneae, des mesodermalen Irislagers sowie des Kieferskelettes in einer Familie

Zur Kenntnis des Cogan-Reese-Syndroms

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