Histologically non‐malignant angioma, with numerous metastases

Shennan, Theodore

doi:10.1002/path.1700190201

Cited by 69 publications

(10 citation statements)

References 6 publications

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“…Liver cysts and/or chylothorax were reported in only 5 cases, but were invariably lethal. [ 1 7 17 22 25 ] Spleen involvement has also been reported in GLA [9] …”

Section: Discussion and Reviewmentioning

confidence: 99%

“…Some authors have described cutaneous involvement, with brown nevi [ 2 3 20 ] or subcutaneous hemangiomas [ 21 22 ] associated with CA. One of our 4 patients (Case 4) presented with diffuse brown nevi.…”

Section: Discussion and Reviewmentioning

confidence: 99%

“…[ 3 7 12 16 17 22 23 26 ] Conversely, several case reports have described the successful use of radiotherapy in GSD, with an overall success rate for the treatment of localized lesions of about 75% [38] . Maximal therapeutic benefit seems to be achieved with the use of 36 to 45 Gray in total, administered in 2-Gray units [38] .…”

Section: Discussion and Reviewmentioning

confidence: 99%

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Cystic angiomatosis, a heterogeneous condition

et al. 2016

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Background:Cystic angiomatosis (CA) is a rare disorder causing bony cysts. It displays some similarity to Gorham–Stout disease (GSD), but has a much better local prognosis, despite the larger number of cysts. These 2 conditions also differ in terms of their location, visceral involvement, and response to treatment.Methods:We report 4 cases of CA, including 1 sclerosing form, which we compare with cases from a literature review performed with PRISMA methodology.Results:We reviewed 38 articles describing 44 other patients. Mean age at diagnosis for the 48 patients (our 4 patients + the 44 from the review) was 22.5 years, and 28 of the patients were men. The femur was involved in 81% (n = 39), the pelvis in 73% (n = 35), the humerus in 52% (n = 25), the skull in 48% (n = 23), and the vertebrae in 44% (n = 21). Visceral lymphangiomatosis (either clinical, or detected on autopsy) was also reported in 35% (n = 18) of the patients. The spleen was the most frequently involved organ (n = 12), followed by the lungs and pleura (n = 8). Liver cysts and/or chylothorax were rarely reported (5 cases), but were invariably fatal. Radiation therapy on bone or soft tissue masses was ineffective, as was interferon alpha, in the 2 patients in which this drug was tested. The efficacy of bisphosphonate was at best equivocal.Conclusion:The progression of CA is unpredictable and treatments effective against GSD, such as bisphosphonates and radiotherapy, have proved ineffective for this condition. New treatments are thus urgently required.

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“…Liver cysts and/or chylothorax were reported in only 5 cases, but were invariably lethal. [ 1 7 17 22 25 ] Spleen involvement has also been reported in GLA [9] …”

Section: Discussion and Reviewmentioning

confidence: 99%

Section: Discussion and Reviewmentioning

confidence: 99%

Section: Discussion and Reviewmentioning

confidence: 99%

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Cystic angiomatosis, a heterogeneous condition

et al. 2016

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“…3 The fi rst case was reported by Shennan 4 3 Most mediastinal hemangiomas are located in the anterior mediastinum, 6 and a few have been reported in the posterior mediastinum. Cohen et al 1 indicated that nearly half of all patients are symptomatic.…”

Section: Discussionmentioning

confidence: 99%

Thoracoscopic resection of a mediastinal venous hemangioma: Report of a case

et al. 2011

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Mediastinal hemangioma is a rare tumor, accounting for 0.5% or fewer of all mediastinal tumors in most reports. We herein report a case of thoracoscopic resection of venous hemangioma in the middle mediastinum. A 48-year-old man was referred to our hospital for dysphagia. A chest computed tomography scan showed the mass to have a smooth surface and heterogeneous contents. Magnetic resonance imaging demonstrated the morphology of the vascular tumor to be a hyperintense mass on a T2-weighted image. Using thoracoscopic surgery, the tumor was completely extirpated and confirmed histologically to be a venous hemangioma. In this case, thoracoscopic surgery provided a satisfactory view and facilitated correct handling for the mediastinal venous hemangioma.

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“…Various workers (eg, Shennan, 1914;Wright, 1949) have commented that the appearances of the blood film in patients with malignant haemangio-endothelioma resemble those of pernicious anaemia. Bourne, Cook, and Williams (1965) have described two patients with a leuco-erythroblastic anaemia which they attributed to infiltration of the marrow by haemangio-endothelioma.…”

Section: Discussionmentioning

confidence: 99%