Histological Typing of Odontogenic Tumours

Kramer, I.R.H.; Pindborg, J. J.; Shear, Mervyn

doi:10.1007/978-3-662-02858-2

Cited by 905 publications

(663 citation statements)

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“…Therefore, the GOC, though rare, is now relatively well known, especially among oral and head and neck pathologists. Moreover, the microscopic features of GOC have been well documented, and the most recent World Health Organization classification includes a definition of the GOC and lists numerous characteristic microscopic features of this cyst [3]. However, it is not uncommon in the practice of pathology to encounter jaw cysts that display some but not all the features that have been described in the ''classic'' GOC.…”

Section: Discussionmentioning

confidence: 99%

“…Cases with discrepancies of opinion in this regard were reviewed by two of us (CBF and RBB) and a final determination was made. In all cases, the decision of whether to accept or reject the lesion as GOC was based on interpretation of the diagnostic criteria set forth by Gardner et al [2] and Kramer et al [3]. After this review, the cases were separated into two groups based on the diagnosis: 46 of the cases were diagnosed as ''GOC'' and 21 cases as ''non-GOC''.…”

Section: Methodsmentioning

confidence: 99%

“…The selection of these parameters was based on and adapted from previously reported microscopic features for GOC [2,3,7,8]. Examples of these parameters are shown in Fig.…”

Section: Microscopic Parametersmentioning

confidence: 99%

“…In 1988, Gardner and colleagues [2] described eight additional cases, preferring the term ''glandular odontogenic cyst'' (GOC). This moniker was also adopted by the World Health Organization [3] in 1992, reflecting the theory that these cysts were most likely of odontogenic rather than salivary gland origin. Odontogenic origin has also been confirmed immunohistochemically by several investigators [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Fowler

Brannon

Kessler

et al. 2011

Head and Neck Pathol

128

172

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The glandular odontogenic cyst (GOC) is now a relatively well-known entity with recent reviews indicating over 100 cases reported in the English literature. The GOC's importance relates to the fact that it exhibits a propensity for recurrence similar to the odontogenic keratocyst, and that it may be confused microscopically with central mucoepidermoid carcinoma (CMEC). Numerous histopathologic features for the GOC have been described, but the exact microscopic criteria necessary for diagnosis have not been universally accepted. Furthermore, some of the microscopic features of GOC may also be found in dentigerous, botryoid, radicular, and surgical ciliated cysts. The purpose of this multicenter retrospective study is to further define the clinical, radiographic, and microscopic features of GOC, to determine which microscopic features may be helpful for diagnosis in problematic cases, to determine the most appropriate treatment, and to determine if GOC and CMEC share a histopathologic spectrum. In our series of 46 cases, the mean age at diagnosis was 51 years with 71% of cases in the 5th-7th decades. No gender predilection was noted. 80% of cases occurred in the mandible, and 60% of the lesions involved the anterior regions of the jaws. Swelling/expansion was the most common presenting complaint, although some cases were asymptomatic. Radiographically, most cases presented as a well-defined unilocular or multilocular radiolucency involving the periapical area of multiple teeth. Some lesions displayed a scalloped border. Cases also presented in dentigerous, lateral periodontal, and ''globulomaxillary'' relationships. The canine area was a common location for maxillary cases. All cases were treated conservatively (enucleation, curettage, cystectomy, excision). Follow-up on 18 cases revealed a recurrence rate of 50% (9/18), with 6 cases recurring more than once (range of follow-up: 2 months to 20 years; average length of follow-up: 8.75 years). The mean interval from initial treatment to first recurrence was 8 years, and from first recurrence to second recurrence was 5.8 years. Two cases recurred three times and the interval from second to third recurrence was 7 years (exact interval only documented in one case). All cases exhibited eosinophilic cuboidal (hobnail) cells, a feature not specific for GOC, but necessary for diagnosis, in our opinion. Univariate analysis indicated several features that are most helpful in distinguishing GOC from GOC mimickers in problematic cases, including: (1) the presence of microcysts (P \ 0.0001); (2) epithelial spheres 123Head and Neck Pathol (2011) 5:364-375 DOI 10.1007 (P \ 0.0001); (3) clear cells (P = 0.0002); (4) variable thickness of the epithelial cyst lining (P = 0.0002); and (5) multiple compartments (P = 0.006). Stratified analysis indicated that when microcysts are present, epithelial spheres and multiple compartments are still significant, and clear cells are marginally significant in distinguishing GOCs from GOC mimickers. The presence of microcysts (P = 0.00...

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The selection of these parameters was based on and adapted from previously reported microscopic features for GOC [2,3,7,8]. Examples of these parameters are shown in Fig.…”

Section: Microscopic Parametersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Fowler

Brannon

Kessler

et al. 2011

Head and Neck Pathol

128

172

View full text Add to dashboard Cite

show abstract

“…They are present in unerupted teeth, but the proliferative potential of odontogenic epithelium in PFs of teeth in this condition has not been elucidated. Dentigerous cysts (DC) may also affect unerupted teeth, enclosing the crown and attaching to the neck of the unerupted tooth [6]. The origins of DCs have been attributed to odontogenic epithelium [1-4, 6, 7].…”

Section: Introductionmentioning

confidence: 99%

Odontogenic Epithelium: Immunolabeling of Ki-67, EGFR and Survivin in Pericoronal Follicles, Dentigerous Cysts and Keratocystic Odontogenic Tumors

Oliveira

Lauxen

Chaves

et al. 2010

Head and Neck Pathol

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Association of DSM-5 Betel-Quid Use Disorder With Oral Potentially Malignant Disorder in 6 Betel-Quid Endemic Asian Populations

Lee

Yang

et al. 2018

JAMA Psychiatry

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This international study gathered data about BQ users across 6 Asian populations, and it demonstrates that DSM-5 symptoms could fulfill a BUD construct. Most current Asian users of BQ already have BUD, which is correlated with risk of OPMD. Among individuals with moderate to severe BUD who used BQ, tolerance and a larger amount or longer history of BQ use are the key symptoms that correlated with enhanced risk of OPMD. These findings play an important role in providing a new indication of an additional psychiatric management plan for users of BQ who have BUD.

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Histological Typing of Odontogenic Tumours

Cited by 905 publications

References 0 publications

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Odontogenic Epithelium: Immunolabeling of Ki-67, EGFR and Survivin in Pericoronal Follicles, Dentigerous Cysts and Keratocystic Odontogenic Tumors

Association of DSM-5 Betel-Quid Use Disorder With Oral Potentially Malignant Disorder in 6 Betel-Quid Endemic Asian Populations

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