Histological Typing of Cancer and Precancer of the Oral Mucosa

Pindborg, J. J.; Reichart, Peter A.; Smith, Colin J.; Waal, I. van der

doi:10.1007/978-3-642-60592-5

Cited by 461 publications

(336 citation statements)

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“…As previously described, verrucous carcinoma is a benignappearing lesion with ''pushing'' borders, and the basement membrane can appear to be intact [27]. This histology often presents a diagnostic challenge, as the differential diagnosis includes pseudoepitheliomatous hyperplasia, squamous papilloma, keratosis, and verrucous hyperplasia [28,29].…”

Section: Discussionmentioning

confidence: 98%

Temporal Bone Verrucous Carcinoma: Outcomes and Treatment Controversy

Miller¹,

Martin

Juillard³

et al. 2010

The Laryngoscope

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Verrucous carcinoma is a rare tumor that presents in the head and neck with the most common sites being the oral cavity and larynx. Fourteen cases of verrucous carcinoma of the temporal bone have been described in literature; this study aims to examine treatment outcomes and discuss the controversy surrounding postoperative radiation. The study design included a literature review along with individual case report in the setting of a tertiary care medical center. Outcome analysis of all cases of verrucous carcinoma of the temporal bone, which are documented in the English literature, and presentation of a single patient report including gross, histologic and radiologic analyses were performed. The longest recorded survival for verrucous carcinoma of the temporal bone occurs in patients treated with surgery alone. Poorer outcomes for patients treated with adjuvant (chemo)radiation may be due to more advanced stage of disease at the time of treatment. Early reports of radiation leading to tumor dedifferentiation or early recurrence are not supported by more recent studies. Whether adjuvant radiation therapy is indicated in verrucous carcinoma of the temporal bone remains controversial.

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Section: Discussionmentioning

confidence: 98%

Temporal Bone Verrucous Carcinoma: Outcomes and Treatment Controversy

Miller¹,

Martin

Juillard³

et al. 2010

The Laryngoscope

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“…15 Histological grading was performed following the WHO criteria for squamous cell carcinomas of the oral mucosa. 16 To dichotomize, patients were divided into the categories smoker and non-smoker, if having a history of 1 or <1 pack-year during the last 16 years. For alcohol consumption, patients were categorized accordingly, having >2 or 2 standard drinks on every day.…”

Section: Patients Tumor Samples and Clinical Data Collectionmentioning

confidence: 99%

“…Extracted DNA was analyzed for mucosal high risk HPV-DNA and HPV genotypes (16,18,31,33,35,39,45, 51, 52, 56, 58, 59, 68, 73 and 82) by PCR optimized for DNA extracted from FFPE tissue, followed by bead-based hybridization (Luminex technology, Multimetrix, Progen, Heidelberg), as described previously. 17,18 HPV-DNA contamination protection steps (e.g., new microtome blades for every block, separated pre and post PCR areas) were applied and appropriate controls (tissue-free paraffin blocks, water-controls) were processed to monitor potential high risk HPV-DNA contamination.…”

Section: Hpv-dna Genotypingmentioning

confidence: 99%

CD56-positive lymphocyte infiltration in relation to human papillomavirus association and prognostic significance in oropharyngeal squamous cell carcinoma

et al. 2016

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Human papillomavirus (HPV)-related squamous cell carcinoma of the oropharynx (OSCC) are clinical and biological distinct from their HPV-unrelated counterparts. Patients with HPV-related OSCC display improved prognosis and therefore we investigated possible immune cell infiltrations associated with this tumor phenotype. We retrospectively analyzed a randomly selected cohort of 140 OSCC for presence of immune cells and HPV by immunohistochemistry and PCR followed by beadbased hybridization (Luminex technology). HPV prevalence was 24.3% as determined by positive staining of p16INK4a and detection of high risk HPV-DNA. We found significantly higher numbers of CD56 positive (CD561) cells in tumor and surrounding microenvironment in HPV-associated compared to HPV-negative OSCC (t-test: p 5 0.004 and p 5 0.002). For the entire cohort presence of CD561 cells was associated with increased overall survival independent from HPV (Kaplan-Meier: p 5 0.002; Cox regression: p 5 0.042). Presence of CD561 cells also correlated with a better outcome in HPV-negative and especially in HPV-negative OSCC with alcohol consumption 2 standard drinks per day (Kaplan-Meier: p 5 0.05 and p 5 0.003). Immunofluorescence localization of granular Granzyme B (GZMB) within CD561 cells and coexpression of CD16 and CD56 suggests that detected CD561 cells mainly represent cytotoxic Natural Killer (NK) cells. The fraction of potentially cytotoxic NK cells was significantly higher in HPV-associated compared to HPV-negative OSCC (Mann-Whitney-U-Test: p 5 0.011). The elevated abundance and activity of cytotoxic NK cells in OSCC with HPV driven carcinogenesis might contribute to favorable outcome in HPV-related OSCC.Head and neck cancer (HNC, comprising cancers of the oral cavity, lip, pharynx, nasopharynx and larynx) is ranking at position seven of newly diagnosed cancers and cause of cancer death worldwide, with 4.8% of total cancer incidence and 4.6% of total cancer mortality. 1 In particular oropharyngeal squamous cell carcinomas (OSCC) are related to high risk human papillomavirus (HPV) infection, which is accepted to be causally connected to HNC. 2,3 A recently published metaanalysis demonstrates a rising incidence of HPV1 OSCC in the United States from 21% (pre-1990), to 51% (1990-1999), to 65% (2000-2013). 4 Patients with HPV-associated OSCC show lower levels of disease recurrence and progression compared to patients with HPV-negative OSCC. Even with good loco regional tumor control, patients with HPV-associated OSCC have similar rates of distant metastases as patients with HPVnegative OSCC. Further efforts are needed to understand clinical and biological features of this distinct disease. 2,5,6 Molecular basis of HPV-associated cancers differ from their HPVunrelated counterparts. 3 Pathways related to cell cycle control or apoptosis (commonly affected by mutations in HPVnegative cancers) are silenced at protein level by HPVoncoproteins (mainly E6 and E7). It has been speculated that lower levels of genetic alterations contribute to better treat...

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“…Tumor histologic grade was defined according to the WHO classification [18]. Pattern of invasion (POI) was examined at the host/tumor interface.…”

Section: Patientsmentioning

confidence: 99%

Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients

Yanamoto

Yamada

Takahashi

et al. 2013

Pathol. Oncol. Res.

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Locoregional recurrence of oral tongue squamous cell carcinoma (OTSCC) has been considered a poor prognostic entity in terms of survival rate.The purpose of this study was to evaluate the incidence of locoregional recurrence and to identify significant risk factors for locoregional recurrence in early-stage OTSCC. We retrospectively reviewed the records of 58 patients who underwent radical surgery for T1-2N0 OTSCC. The local recurrence and regional recurrence rates were 10.3% (6/58 patients) and 15.5% (9/58 patients) in this study, respectively. The survival rate of patients with local recurrence was 66.7%, which was significantly lower than that (96.2%) of patients without local recurrence, whereas the survival rates of patients with or without regional recurrence were not significantly difference. Pattern of invasion (POI), neoadjuvant chemotherapy (NAC) and the status of the surgical margin were identified as factors influencing local recurrence. In particular, the status of the deep surgical margin was a high potential independent risk factor. The deep surgical margin was resected closely in many NAC-treated cases, suggesting that NAC may lead to local recurrence and a poor outcome. No efficacy of NAC was observed, suggesting that the standard treatment for early OTSCC is surgery alone.

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Histological Typing of Cancer and Precancer of the Oral Mucosa

Cited by 461 publications

References 0 publications

Temporal Bone Verrucous Carcinoma: Outcomes and Treatment Controversy

Temporal Bone Verrucous Carcinoma: Outcomes and Treatment Controversy

CD56-positive lymphocyte infiltration in relation to human papillomavirus association and prognostic significance in oropharyngeal squamous cell carcinoma

Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients

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