Histological Types of Gastric Cancer and its Relationship with Intestinal Metaplasia

Muñóz, Núbia; Matko, I

doi:10.1007/978-3-662-41032-5_9

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…In addition, it com-Prtses control subjects suffering exclusively from or-}hopedic disorders and admitted to a hospital different rom those which provided the cases. Although this Was necessary under the existing conditions it may, nevertheless, raise questions concerning the compara-Epidemiological evaluation of the role of nutrition in the development of gastric cancer [or its postulated precursors (Munoz and Matko, 1972;] has relied mainly on case-control investigations (Wynder et al, 1963;Acheson and Doll, 1964;Meinsma, 1964;Higginson, 1966;Graham et at., 1967;Hirayama, 1971;Haenszel et al, 1972;Bjelke, 1974;Madan et al, 1974;1975;Haenszel et al, 1976a,b;) although risk correlations (Haenszel, 1958;Hakama and Saxen, 1967;Munoz et al, 1968; Armstrong and Doll, 1975;Joosens and Geboers, 1981;Tominaga et al, 1982;Correa et al, 1983;Kono et al, 1983) and cohort studies (Hirayama, 1982) have also been undertaken. Most authors interpret the collective evidence as indicating that salted and starchy foods increase the risk of gastric cancer whereas fresh fruits and vegetables decrease this risk (Graham, 1975;Haenszel et al, 1976a;Weisburger, 1979;Hirayama, 1982;Nomura, 1982;Tominaga et al, 1982;Correa et al, 1983;Kolonel et at., 1983;Mirvish, 1983;Palmer and Bakshi, 1983).…”

Section: Discussionmentioning

confidence: 99%

Diet and Cancer of the Stomach: A Case‐control Study in Greece

Trichopoulos

Ouranos

Day

et al. 1985

Intl Journal of Cancer

187

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A case-control study focusing on the role of diet in the etiology of gastric cancer was undertaken in Piraeus, the sister city of Athens, in a population characterized by ethnic homogeneity but substantial heterogeneity with respect to dietary habits. The case series consisted of 110 consecutive patients with histologically confirmed adenocarcinoma of the stomach, admitted to two teaching hospitals during a 3-year period; the control series consisted of orthopedic patients admitted to a nearby hospital for accidents, fractures and other orthopedic disorders, during the same time period. Dietary histories concerning the frequency of consumption (per month or per week) of about 80 food items were obtained by the same interviewer. Cases reported significantly less frequent consumption of lemons, oranges, brown bread, and raw, salad-type vegetables (particularly lettuce, onions and cucumbers) and, independently, significantly more frequent consumption of pasta, beans and nuts. A relative risk of about 40 was found between extreme quintiles when the above 9 food items were combined in a linear risk score. Use of an index constructed from the study material will clearly overestimate the level of risk between the extreme quintiles, but nevertheless the risk differences appear noteworthy, and consistent with the international variation in the incidence of gastric cancer. No significant associations were found with alcoholic beverages, coffee or tea.

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Section: Discussionmentioning

confidence: 99%

Diet and Cancer of the Stomach: A Case‐control Study in Greece

Trichopoulos

Ouranos

Day

et al. 1985

Intl Journal of Cancer

187

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“…In addition, 25 healthy volunteers were examined. Subjects were selected without previous knowledge of PGA phenotypes, and were classified into 10 diagnostic groups by criteria based on medical history, endoscopy and histological examination of the endoscopic biopsies as follows: (Note: in this study partial gastrectomy or atrophic gastritis/intestinal metaplasia are regarded as premalignant changes of the stomach (Munoz & Matko 1972, Correa et al 1970, Schrumpf et al 1977).…”

Section: Patientsmentioning

confidence: 99%

Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer

et al. 1986

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Electrophoretic pepsinogen A patterns were determined in gastric fundic mucosa biopsies from 601 patients with various gastric disorders and 25 healthy volunteers. Pepsinogen A patterns with an intense fraction 5 appeared to be associated with gastric cancer and premalignant changes of the stomach (p< In 60 individuals pepsinogen A patterns were determined in normal mucosa from different parts of the stomach. No differences were found between these patterns. In 29 out of 59 gastric cancer patients pepsinogen A could be demonstrated in the macroscopically malignant tissue. In two cases a different pattern compared with uninvolved fundic mucosa was observed.During a follow up study, major changes in the pepsinogen A pattern were observed in 7 out of 56 patients. In 8.6% of the examined patients urinary pepsinogen A patterns differed considerably as compared with the pattern observed in the gastric fundus.The results suggest that the highly significant association between intense Pg5 (the product of the D gene) and gastric cancer or its precursors may be caused by genetic as well as nongenetic factors.

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Histological Types of Gastric Cancer and its Relationship with Intestinal Metaplasia

Cited by 2 publications

References 7 publications

Diet and Cancer of the Stomach: A Case‐control Study in Greece

Diet and Cancer of the Stomach: A Case‐control Study in Greece

Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer

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