Histological Subtyping and Nuclear Grading of Renal Cell Carcinoma and Their Implications for Survival: A Retrospective Nation-Wide Study of 629 Patients

Guðbjartsson, Tómas; Hardarson, Sverrir; Pétursdóttir, Vigdís; Thoroddsen, Ásgeir; Magnússon, Jónas; Einarsson, Guðmundur

doi:10.1016/j.eururo.2005.04.016

Cited by 173 publications

(136 citation statements)

References 26 publications

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“…Tabibi et al 8 showed mean age was 55.3 years. Gudbjartsson et al 9 and Renshaw et al 10 showed similar mean age values ranging from 52 to 68.3 years.…”

Section: Discussionsupporting

confidence: 51%

Histopathological Analysis of Renal Tumours- A Two Year Study From a Tertiary Care Centre

Chathukutty¹,

Pothen²,

Kandasamy³

et al. 2017

jemds

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BACKGROUNDThere is an increased incidence of renal tumours every year in the last three decades, RCC being the most common. There is little published data on the spectrum of renal tumours in India, especially Southern parts like Kerala. Hence, this study is undertaken to analyse the relative frequencies of different types of renal tumours and their histopathological characteristics.The aim of the study is to find out the mean age of presentation, mode of presentation and gender predominance of renal tumours, the histopathological subtype of renal tumours and microvascular invasion. MATERIALS AND METHODSThis was a descriptive study carried out in the Department of Pathology, Government Medical College, Kottayam. 51 nephrectomy specimens of renal neoplasm received during the period of two years were studied. Statistical analysis was done using SPSS version 16. RESULTSAmong 51 nephrectomy specimens of renal neoplasm, 90.2% (46/51 cases) were of malignant tumours. Of 46 malignant cases 31/51 cases were of clear cell carcinoma, 7/51 cases were of papillary carcinoma, 5/51 cases were of chromophobe carcinoma, 1/51 were of multilocular cystic RCC and 2/51 were of unclassified RCC. Of 5 benign cases (9.8%) 2/51 were of oncocytoma, 1/51 were of solitary fibrous tumour, 1/51 were of clear cell sarcoma and 1/51 were of angiomyolipoma. Majority of renal neoplasms (90.2%) were RCC, seen predominantly in middle aged males (mean age is 52.41 years). They mostly presented with symptoms of abdominal pain (37.2%) and mass (31.3%). The classical symptom triad (macroscopic haematuria, palpable tumour and pain) was less commonly seen (8.7%). Clear cell carcinoma was the most common histological type of renal tumours (60.7%) and also had the most number of capsular (60%) and renal sinus invasion (72%), which may indicate bad prognosis. As the size, stage/ grade of the tumour increased, the symptoms did not increase. Therefore, relative paucity of symptoms does not mean that the tumour has not made much progression/ is completely curable/ resectable. CONCLUSIONIncidental tumours being in the lower stages and lower nuclear grades indicate that early detection of renal neoplasms by radiological screening may have some value. However, large scale case control studies are needed to make accurate analysis of renal neoplasms including the measurement of cancer specific survival and prognosis. The incidence rates of RCC have risen steadily each year during the last three decades in most parts of the world with an average increase of 2% to 3% per year. 1 The increased incidence is primarily due to two reasons. One is the increased detection via radiological methods like USG and CT. 'Financial or Other Competing Interest': None. Submission 24-10-2017, Peer Review 21-11-2017, Acceptance 27-11-2017, Published 11-12-2017. Corresponding Author: Dr. Lillykutty Pothen, Kaniankunnel House, Gandhinagar P. O, Kottayam. E-mail: glamskan@gmail.com DOI: 10.14260/jemds/2017/1453 Another reason is the increased prevalence of risk factors l...

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“…Tabibi et al 8 showed mean age was 55.3 years. Gudbjartsson et al 9 and Renshaw et al 10 showed similar mean age values ranging from 52 to 68.3 years.…”

Section: Discussionsupporting

confidence: 51%

Histopathological Analysis of Renal Tumours- A Two Year Study From a Tertiary Care Centre

Chathukutty¹,

Pothen²,

Kandasamy³

et al. 2017

jemds

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“…[5][6][7][8][9][10] Thus, a priori identification of this phenotype is important in clinical decision making.…”

Section: Introductionmentioning

confidence: 99%

Positron Emission Tomography/Computed Tomography Identification of Clear Cell Renal Cell Carcinoma: Results From the REDECT Trial

Divgi

Uzzo

Gatsonis

et al. 2013

JCO

210

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A B S T R A C T PurposeA clinical study to characterize renal masses with positron emission tomography/computed tomography (PET/CT) was undertaken. Patients and MethodsThis was an open-label multicenter study of iodine-124 ( 124 I) -girentuximab PET/CT in patients with renal masses who were scheduled for resection. PET/CT and contrast-enhanced CT (CECT) of the abdomen were performed 2 to 6 days after intravenous 124 I-girentuximab administration and before resection of the renal mass(es). Images were interpreted centrally by three blinded readers for each imaging modality. Tumor histology was determined by a blinded central pathologist. The primary end points-average sensitivity and specificity for clear cell renal cell carcinoma (ccRCC)-were compared between the two modalities. Agreement between and within readers was assessed. Results 124I-girentuximab was well tolerated. In all, 195 patients had complete data sets (histopathologic diagnosis and PET/CT and CECT results) available. The average sensitivity was 86.2% (95% CI, 75.3% to 97.1%) for PET/CT and 75.5% (95% CI, 62.6% to 88.4%) for CECT (P ϭ .023). The average specificity was 85.9% (95% CI, 69.4% to 99.9%) for PET/CT and 46.8% (95% CI, 18.8% to 74.7%) for CECT (P ϭ .005). Inter-reader agreement was high ( range, 0.87 to 0.92 for PET/CT; 0.67 to 0.76 for CECT), as was intrareader agreement (range, 87% to 100% for PET/CT; 73.7% to 91.3% for CECT). ConclusionThis study represents (to the best of our knowledge) the first clinical validation of a molecular imaging biomarker for malignancy. 124I-girentuximab PET/CT can accurately and noninvasively identify ccRCC, with potential utility for designing best management approaches for patients with renal masses.

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“…This is partly because, as yet, no consensus has been reached on a universal tumor grading system (Kanamaru et al 2001, Medeiros et al 1997. The observed five-year disease-specific survival (DSS) rate is approximately 90% for G1, 70-85% for G2, 45-60% for G3, and 15-30% for G4 (Gudbjartsson et al 2005, Ficarra et al 2001. Currently, different grading systems are utilized at different institutions.…”

Section: Histopathological Tumor Gradingmentioning

confidence: 99%

Prognostic Factors in Renal Cell Carcinoma: An Evaluation of T-Stage, Histopathological Grade, p53, Ki-67, COX-2, and Her-2 Expressions

Kankuri-Tammilehto¹

2012

Emerging Research and Treatments in Renal Cell Carcinoma

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Histological Subtyping and Nuclear Grading of Renal Cell Carcinoma and Their Implications for Survival: A Retrospective Nation-Wide Study of 629 Patients

Cited by 173 publications

References 26 publications

Histopathological Analysis of Renal Tumours- A Two Year Study From a Tertiary Care Centre

Histopathological Analysis of Renal Tumours- A Two Year Study From a Tertiary Care Centre

Positron Emission Tomography/Computed Tomography Identification of Clear Cell Renal Cell Carcinoma: Results From the REDECT Trial

Prognostic Factors in Renal Cell Carcinoma: An Evaluation of T-Stage, Histopathological Grade, p53, Ki-67, COX-2, and Her-2 Expressions

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