Histological study on the effect of nicotine on adult male guinea pig thin skin

Eltony, Sohair A.; Ali, Safaa M.

doi:10.5115/acb.2017.50.3.187

Cited by 8 publications

(7 citation statements)

References 45 publications

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“…This study was designed to evaluate the probable benefit of minocycline on depression-like behaviours and oxidative stress induced by chronic sleep deprivation in mice. The results from the current study depicted that sleep deprivation induced oxidative stress by enhancing production and activity of reactive oxygen species, a mechanism that has been linked to a depression-like phenotype in earlier studies (21,22).…”

Section: Discussionsupporting

confidence: 66%

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Minocycline Attenuated Depressive-Like Phenotype in Sleep-Deprived Mice via its Antioxidant Effect

Anthony,

Kesiena,

Lily

et al. 2023

MJMHS

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Introduction: Central nervous system (CNS) neuropathologies are the most common effects of insufficient sleep/prolonged wakefulness. This puts people who undergo sleep deprivation in the course of their daily lives at risk of certain affective disorders such as depression. Minocycline is an antibiotic that can penetrate the CNS, which puts it at the forefront of numerous neuropathologies. This research was therefore intended to investigate into the possible anti-depressant effect of minocycline in mice exposed to chronic sleep deprivation. Methods: Thirty (30) mice were grouped into five (n=6) and treated with either distilled water, minocycline or astaxanthin. Four out of the five groups were exposed to the sleep deprivation set-up. After a 7-day treatment, all groups were subjected to behavioural tests. Subsequently, biochemical assays and histology of selected brain regions were carried out. Experimental data were analysed using one-way analysis of variance and another post-hoc test. Results: Results obtained suggest that minocycline attenuated the alterations in mood behaviour caused by sleep deprivation with a concurrent reversal of sleep-deprivation induced oxidative stress in mice. Conclusion: In conclusion, minocycline could be considered a reliable intervention in further studies on depression in sleep deprivation models.

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Section: Discussionsupporting

confidence: 66%

“…Photomicrographs were subsequently obtained using a digital camera. Neuronal density or neuronal count was also extrapolated from the photomicrographs as a ratio of viable neuronal cell counts to the square area of the circular view in a section (21).…”

Section: Histology and Estimation Of Neuronal Densitymentioning

confidence: 99%

Minocycline Attenuated Depressive-Like Phenotype in Sleep-Deprived Mice via its Antioxidant Effect

Anthony,

Kesiena,

Lily

et al. 2023

MJMHS

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“…The alteration of collagen metabolism contributes to the slow process of wound healing and this can also contribute to the aging process [ 10 ]. NIC has been linked to premature skin aging and delayed wound healing as a result of nicotine receptors located in keratinocytes of the skin [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Nicotine Exerts Cytotoxic Effects in a Panel of Healthy Cell Lines and Strong Irritating Potential on Blood Vessels

Chioran

Sitaru

Macaşoi

et al. 2022

IJERPH

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The use of tobacco products is a major global public health issue, as it is the leading cause of preventable death worldwide. In addition, nicotine (NIC) is a key component of electronic and conventional cigarettes. Although nicotine’s addictive potential is well known, its health effects are not entirely understood. Thus, the main objective of the present study was to evaluate its toxicological profile both in vitro, at the level of three healthy cell lines, and in ovo, at the level of the chorioallantoic membrane. Five different concentrations of nicotine were used in keratinocytes, cardiomyocytes, and hepatocytes for the purpose of evaluating cell viability, cell morphology, and its impact on nuclei. Additionally, the hen’s egg test on the chorioallantoic membrane (HET-CAM) method was used to assess the biocompatibility and irritant potential of the chorioallantoic membrane. Across all cell lines studied, nicotine was proven to be significantly damaging to cell viability, with the highest concentration tested resulting in less than 2% viable cells. Moreover, the morphology of cells changed dramatically, with alterations in their shape and confluence. Nicotine-induced cell death appears to be apoptotic, based on its impact on the nucleus. In addition, nicotine was also found to have a very strong irritating effect on the chorioallantoic membrane. In conclusion, nicotine has an extremely strong toxicological profile, as demonstrated by the drastic reduction of cell viability and the induction of morphological changes and nuclear alterations associated with cellular apoptosis. Additionally, the HET-CAM method led to the observation of a strong irritating effect associated with nicotine.

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“…Tobacco smoke causes oxidative stress so that insufficient oxygen is supplied to the skin resulting in tissue ischemia and blood vessel occlusion. 13 Our work showed that pruritus was of gradual onset in 93.3% and progressive course in 44.8% of cases, the mean duration of pruritus was 4.23± 4.9 months. Pruritus was generalized in 73.8% and localized in 26.2%.…”

Section: Discussionmentioning

confidence: 48%

Clinical and Laboratory Characteristics of Elderly Patients with Pruritus

Aboeldahab

Khalil

El-Dawla

2021

CCID

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Introduction For elderly, pruritus is considered the most common complaint in outpatient clinic. Pruritus occurs in association with primary skin disorders and can also be caused by many diseases and drugs. The aim of the work was to study clinical and laboratory characteristics of elderly patients with pruritus in Sohag, Egypt. Patients and Methods A cross-sectional study was conducted on 225 patients aged ≥60 years of both sexes complaining of pruritus and 160 age- and sex-matched patient group complaining of non-pruritic dermatological diseases. CBC, ESR, renal function tests, serology for HBV and HCV and blood glucose levels were done routinely in all patients (both groups). Skin biopsy was done in some selected cases. Results The mean duration of pruritus was 4.23 ± 4.9 months and was generalized in 73.8% of cases with moderate severity in 35.1% with winter exacerbation in 20%. Dermatological causes of pruritus were detected in 54.2%, followed by systemic causes in 29.8%. Eczema was the most common skin cause of senile itching in 33.7%, while renal diseases were the most common systemic cause in 46.2%. Conclusion Senile pruritus is a common problem in elderly. Early and proper management is mandatory to improve their quality of life.

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Histological study on the effect of nicotine on adult male guinea pig thin skin

Cited by 8 publications

References 45 publications

Minocycline Attenuated Depressive-Like Phenotype in Sleep-Deprived Mice via its Antioxidant Effect

Minocycline Attenuated Depressive-Like Phenotype in Sleep-Deprived Mice via its Antioxidant Effect

Nicotine Exerts Cytotoxic Effects in a Panel of Healthy Cell Lines and Strong Irritating Potential on Blood Vessels

Clinical and Laboratory Characteristics of Elderly Patients with Pruritus

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