Histological study of the possible protective action of platelet rich plasma on the injurious effect induced by aluminum chloride on albino male rat cerebellar cortex

Atorvastatin and ezetimibe protect against hypercholesterolemia-induced lung oxidative stress, inflammation, and fibrosis in rats

“…Hypercholesterolemia not only induces oxidative stress but also contributes to inflammation, as the oxidative stress resulting from dyslipidemia triggers an imbalance between pro-inflammatory and anti-inflammatory mediators by increasing the expression of numerous cytokines, including IL-1β, IL-6, TNF-α, and IL-10 ( 31 ). These changes contribute to inflammatory cell infiltration at the sites of lung injury, with consequent alveolar septa thickening and loss of air spaces ( 9 ). Several molecules secreted by inflammatory cells, including hydrogen peroxide, proteases, and phospholipase enzymes, damage lung epithelial cells and cell membrane integrity ( 32 , 33 ).…”

“…Hypercholesterolemia is the most common lipoprotein-related disorder, typically presenting with an increase in both plasma triglyceride and low-density lipoprotein cholesterol (LDL-C) levels and a decrease in high-density cholesterol (HDL-C) ( 6 , 7 ). Patients with PF often have reduced plasma HDL-C levels compared to healthy individuals ( 8 , 9 ). Lipids and lipoproteins are hypothesized to play roles in the early stages of pathogenesis of interstitial lung injury, inflammation, and fibrosis ( 4 ).…”