Histological Studies of Subcutaneous and Intraperitoneal Implants of Trypsin-Prepared Dermal Collagen Allografts in the Rat

Rf, Oliver; Ra, Grant; Cox, Robert W.; Mj, Hulme; Mudie, A.

doi:10.1097/00003086-197603000-00047

Cited by 8 publications

(6 citation statements)

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“…The amount of cross linking might be another explanation for the high recurrence rate, because a non-cross-linked biological mesh was used in the majority of patients [ 22 ]. Cross-links are covalent bonds between the collagen and are supposed to resist collagen degradation by host or bacterial collagenase [ 23 , 24 ]. Thereby, cross linking increases tensile strength which is supposed to result in a lower rate of recurrent hernia compared to non-cross-linked meshes, especially in a contaminated field.…”

Section: Discussionmentioning

confidence: 99%

Is there a place for a biological mesh in perineal hernia repair?

Musters

Lapid

Stoker

et al. 2016

Hernia

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PurposeThis study aimed to determine the outcome of perineal hernia repair with a biological mesh after abdominoperineal resection (APR).MethodAll consecutive patients who underwent perineal hernia repair with a porcine acellular dermal mesh between 2010 and 2014 were included. Follow-up was performed by clinical examination and MRI.ResultsFifteen patients underwent perineal hernia repair after a median of 25 months from APR. Four patients had a concomitant contaminated perineal defect, for which a gluteal fasciocutaneous flap was added in three patients. Wound infection occurred in three patients. After a median follow-up of 17 months (IQR 12–24), a clinically recurrent perineal hernia developed in 7 patients (47 %): 6 of 11 patients after a non-cross-linked mesh and 1 of 4 patients after a cross-linked mesh (p = 0.57). Routine MRI at a median of 17 months revealed a recurrent perineal hernia in 7 of 10 evaluable patients, with clinical confirmation of recurrence in 5 of these 7 patients. No recurrent hernia was observed in the three patients with combined flap reconstruction for contaminated perineal defects.ConclusionA high recurrence rate was observed after biological mesh repair of a perineal hernia following APR.

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Section: Discussionmentioning

confidence: 99%

Is there a place for a biological mesh in perineal hernia repair?

Musters

Lapid

Stoker

et al. 2016

Hernia

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“…32,33 Experimental studies have demonstrated that collagen cross-linking with glutaraldehyde imparted resistance against the activity of collagenase. 34,35 Cross-linked biologic prostheses should therefore be relatively resistant to bacterial degradation, and therefore, safe to use in contaminated or infected hernia repair. Recent clinical reports described accelerated degradation of implanted Surgisis (non-cross-linked) when used to reconstruct abdominal wall defects in infected fields.…”

Section: Discussionmentioning

confidence: 99%

Experimental Evaluation of Four Biologic Prostheses for Ventral Hernia Repair

Gaertner

Bonsack

Delaney

2007

Journal of Gastrointestinal Surgery

139

103

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“…34,35 Furthermore, materials stabilized with GA have been in clinical use for many decades, for example, heart valves and vascular grafts with minimal short-term complications. 36 Because large amounts of GA are cytotoxic, 37,38 the exposure time to GA was minimized by short exposure to GA vapor. The GA vapor crosslinking of the collagenous scaffold was examined by direct contact cytotoxicity testing using murine L-929 fibroblasts.…”

Section: Discussionmentioning

confidence: 99%

Collagen–hydroxyapatite composite prepared by biomimetic process

Lickorish¹,

Ramshaw²,

Werkmeister³

et al. 2003

J Biomedical Materials Res

176

105

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Abstract:A novel bone graft substitute comprising a porous, collagenous scaffold was biomimetically coated with hydroxyapatite using a simulated body fluid solution chemistry method. The scaffold had a porosity of approximately 85%, with pore sizes between 30 m and 100 m. Glutaraldehyde vapor was used to stabilize the collagenous scaffold, giving a significantly increased thermal stability over an unstabilized scaffold, as shown by differential scanning calorimetry. A thin layer (Ͻ10 m) of crystalline hydroxyapatite was deposited onto the stabilized collagenous scaffold by soaking the collagenous construct in simulated body fluid in the presence of calcium silicate glass. The presence of crystalline hydroxyapatite was confirmed by X-ray diffraction, energy-dispersive X-ray spectroscopy, and scanning electron microscopy. In vitro cytotoxicity testing of the composite construct using L-929 fibroblasts (ISO 10993-5) and rabbit periosteal cells revealed a cytocompatible material that supported cellular attachment and proliferation.

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Histological Studies of Subcutaneous and Intraperitoneal Implants of Trypsin-Prepared Dermal Collagen Allografts in the Rat

Cited by 8 publications

References 0 publications

Is there a place for a biological mesh in perineal hernia repair?

Is there a place for a biological mesh in perineal hernia repair?

Experimental Evaluation of Four Biologic Prostheses for Ventral Hernia Repair

Collagen–hydroxyapatite composite prepared by biomimetic process

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