2014
DOI: 10.1186/1471-2407-14-157
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Histological review of skin cancers in African Albinos: a 10-year retrospective review

Abstract: BackgroundSkin cancer is rare among Africans and albinism is an established risk for skin cancer in this population. Ultraviolet radiation is highest at the equator and African albinos living close to the equator have the highest risk of developing skin cancers.MethodsThis was a retrospective study that involved histological review of all specimens with skin cancers from African albinos submitted to The Regional Dermatology Training Center in Moshi, Tanzania from 2002 to 2011.ResultsA total of 134 biopsies fro… Show more

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Cited by 71 publications
(104 citation statements)
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“…Persons with albinism (PWAs) and xeroderma pigmentosum patients also contribute to the high prevalence of epithelial skin cancers observed in this region of Africa and further affect the relative distribution of SCC and BCC . The implementation of a successful comprehensive albino care programme at the RDTC lead in recent years to an improved diagnosis and management of skin cancers in this risk group . In western countries 80% of epithelial tumours are BCC and 20% SCC, however, in PWAs this ratio is inverted, influencing also our data.…”
Section: Discussionmentioning
confidence: 70%
“…Persons with albinism (PWAs) and xeroderma pigmentosum patients also contribute to the high prevalence of epithelial skin cancers observed in this region of Africa and further affect the relative distribution of SCC and BCC . The implementation of a successful comprehensive albino care programme at the RDTC lead in recent years to an improved diagnosis and management of skin cancers in this risk group . In western countries 80% of epithelial tumours are BCC and 20% SCC, however, in PWAs this ratio is inverted, influencing also our data.…”
Section: Discussionmentioning
confidence: 70%
“…revealed almost identical proportion of squamous cell carcinomas and basal cell carcinomas in African albinos. [5] Our patient had all features consistent with photodamage such as freckles, actinic keratosis, malignant lesions, predominantly affecting the photo-exposed parts of the body with histopathology consistent with basal cell carcinoma.…”
mentioning
confidence: 89%
“…Like whites, albino blacks get the same UV-induced DNA damage that keratinocytes accumulate, as shown by their higher rates of non-melanoma skin cancer at younger ages, but those DNA lesions do not transform their melanocytes. The fact that all 4 types of albinos, OCA1 (A&B), OCA2, OCA3, and OCA4 have drastically reduced production of melanin and its precursors 76 and have an almost non-existent incidence of CMM suggests that either melanin or its precursors are probably required for initiating melanoma. Strong evidence that melanoma initiation relies upon melanin content comes from the fact that the action spectrum for melanoma in a fish model (Xiphophorus) is identical to the action spectrum for photosensitized radicals that are only produced by the pigmented fish 77 …”
Section: Resultsmentioning
confidence: 99%