Histological mapping of porcine carotid arteries — An animal model for the assessment of artificial conduits suitable for coronary bypass grafting in humans

Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arteries

“…Comparing main results with the results obtained in this work, in both a decreasing of elastin content from proximal to distal zones can be observed. Respect to collagen content there is not reported a distinguishable tendency in Tomasek et al (2020), unlike this work, where an increment in the percentage of collagen is observed from proximal to distal zone. Therefore, from information provided by literature, it can be indicated that there is no a marked correlation in the histological results for the different arteries, which can be explained by the use of different animal models and by the condition of chronic hypoxia studied in this work.…”

“…Regard to vascular SMCs markers in abdominal zone are highest, which can be related with high cell nuclei density in DAA determined in this work. Tomasek et al (2020) perform a similar study in porcine common carotid artery aged 12-21 weeks, through of an extensive mapping along its length. Comparing main results with the results obtained in this work, in both a decreasing of elastin content from proximal to distal zones can be observed.…”

Using virtual microscopy for the development of sampling strategies in quantitative histology and design‐based stereology

“…Porcine common carotid arteries (B) Quantification of type I and type III collagen within tunica intima and media in porcine common carotid artery (Tomášek et al, 2020).…”

Decellularization of Porcine Carotid Arteries: From the Vessel to the High-Quality Scaffold in Five Hours

“…Vessels scoring 2 and 3 were discarded from this analysis as the mechanical properties might be affected by the remaining cellular material. As shown by previous studies ( Kochová et al, 2012 ; Tomášek et al, 2020 ), morphometric parameters and mechanical properties can significantly vary in different segments of the carotid artery; thus, we divided each vessel into three parts, namely, distal, middle, and proximal segments ( Figure 6A ). These segments were then tested and analyzed separately.…”

“…Its role is to provide stability to the wall, and its presence depends on the type of artery ( Holzapfel et al, 2000 ). Importantly, carotid arteries have been shown to vary between proximal and distal parts in the percentage of collagen, elastin, and actin ( Tomášek et al, 2020 ). The elastin content decreases in favor of the smooth muscle cells and collagen content from the proximal toward the distal part of the vessel wall and inevitably influences the mechanical properties of different vessel segments ( Tomášek et al, 2020 ).…”