Histological, Histochemical, and Ultrastructural Aspects of Interstitial Tissue from the Contralateral Testis in Infertile Men with Monolateral Varicocele

Spera, Giovanni; Medolago-Albani, L; Coia, Lawrence R.; Morgia, Chiara La; Gonnelli, Stefano; Ghilardi, C.

doi:10.3109/01485018308990174

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…A multinucleated cell containing several regularly outlined spherical nuclei (N 1 ), irregularly outlined nucleus (N 2 ) with indentations (thick arrows), interconnected mitochondria (thin arrow) and abundant lipid droplets (Li) are seen. 5875 Cameron et al 1980;Terguem and Dadoune 1981;Pujol et al 1982;Spera et al 1983;Haider et al 1986;Santoro et al 1999) studies. To our knowledge, however, the status of the testes after varicocelectomy has not been studied in detail at the ultrastructural level.…”

Section: Discussionmentioning

confidence: 98%

Ultrastructure of the seminiferous tubules in human testes before and after varicocelectomy

Özgür

Kaya

Doran

et al. 2003

Anatomy and Embryology

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Ultrastructure of the membrana propria and the seminiferous epithelium was studied in infertile human testis both before and 3-6 months after varicocelectomy. The frequent alterations, observed before and after the operation, were extremely thickened membrana propria, deep invaginations, multilamination and knob-like formation of basal laminae and formation of multinucleated spermatids, which were all considered as the common response of the testis to different noxious agents. Although the cells of the seminiferous epithelium were clearly affected by varicocele before varicocelectomy, many areas exhibited normal features after the operation. Furthermore, multinucleated cells, sharing common features of Sertoli cell and spermatogonium, were observed, as well as presence of well-developed annulate lamellae in the Sertoli cells, exhibiting centrioles in the vicinity of their nuclei after varicocelectomy. These multiple ultrastructural observations indicate that Sertoli cell division takes place. This study suggests that if the observation period of the tissue samples after varicocelectomy is long enough, the reversible changes of the tubular cells would be seen much more frequently.

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Section: Discussionmentioning

confidence: 98%

Ultrastructure of the seminiferous tubules in human testes before and after varicocelectomy

Özgür

Kaya

Doran

et al. 2003

Anatomy and Embryology

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“…Варикозное расширение вен семенного канатика рассматривается большинством специалистов как наиболее вероятная причина нарушения сперматогенеза, что определяет показания к оперативному лечению варикоцеле [11,[15][16][17]. При этом механизм влияния варикоцеле на сперматогенез до конца не выяснен [18][19][20][21][22]. С другой стороны, эффективность оперативного лечения варикоцеле для восстановления сперматогенеза крайне низкая и непродолжительная, а в ряде случаев не безвредная для сперматогенеза, что ставит под сомнение необходимость выполнения операции [23][24][25][26][27][28].…”

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Influence of operative treatment of variсocele on the development of arterial hypertension

et al. 2020

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Purpose of the research. To assess the incidence of arterial hypertension in men with varicocele and to identify the relationship between increased blood pressure and surgical treatment of varicocele. Material and methods. A survey of 412 men receiving treatment for arterial hypertension, 482 men previously operated on for varicocele and 68 patients with varicocele who had no surgical treatment was conducted. Results. Varicose veins of the spermatic cord in patients with arterial hypertension were detected in 44.6% of cases, which exceeds the incidence of varicocele occurrence in men of a comparable age category by 1.52 times. Surgical treatment of the left spermatic cord varicocele is combined with the development of arterial hypertension in 51.2% of patients, which is three times higher than the incidence of hypertension in men who didnt undergo surgical treatment for varicocele and twice the frequency of hypertension in the general population of men of comparable age. The more frequent occurrence of renal arterial hypertension in patients who underwent surgical treatment for varicocele may indicate an adverse effect of occlusion of the internal spermatic vein on the state of renal venous hemodynamics. Conclusion. Varicocele should be considered as a compensatory process for renal venous hypertension due to obstruction of blood flow through the renal vein, and elimination of compensatory blood flow can lead to renal venous hypertension, hypoxia and the development of arterial hypertension.

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The Effects of Unilateral, Experimental Varicocele Are Not Mediated Through the Ipsilateral Testis

Hurt

Howards

Turner

1987

Journal of Andrology

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Unilateral varicocele has been associated with diminished male fertility in humans and with bilateral physiologic and histologic changes in the testis of humans and laboratory animals. In particular, left varicocele in Sprague-Dawley rats results in bilateral increases in testicular temperature and blood flow. The mechanism by which unilateral varicocele can cause testicular changes is not known. The purpose of the present study was to determine whether or not the presence of either the ipsilateral or contralateral testicle is necessary for these effects of the varicocele to occur in the opposite testis. Varicoceles were created in adult, male rats by partial constriction of the left renal vein. Bilateral testicular blood flow was measured by a radiolabelled microsphere distribution technique and testicular temperature was taken with a needle probe thermometer. Right or left orchiectomies were performed on selected animals at the time of surgery to establish the unilateral left varicocele. Animals were studied 30 days after surgery. Mean testicular blood flow was significantly increased (P less than 0.01) in all animals having a left varicocele when compared with animals not having a varicocele regardless of whether a unilateral orchiectomy was performed. Likewise, the mean difference between intraabdominal temperature and intratesticular temperature (delta T) was significantly decreased in all groups of animals having varicoceles when compared with groups without varicoceles whether or not an orchiectomy had been performed. Thus, the studied bilateral effects of left-sided, experimental varicocele in the rat are not dependent upon the presence of a left testicle.

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Histological, Histochemical, and Ultrastructural Aspects of Interstitial Tissue from the Contralateral Testis in Infertile Men with Monolateral Varicocele

Cited by 6 publications

References 12 publications

Ultrastructure of the seminiferous tubules in human testes before and after varicocelectomy

Ultrastructure of the seminiferous tubules in human testes before and after varicocelectomy

Influence of operative treatment of variсocele on the development of arterial hypertension

The Effects of Unilateral, Experimental Varicocele Are Not Mediated Through the Ipsilateral Testis

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