Histological heterogeneity and distributional difference of gastric carcinosarcoma: report of 4 cases and literature review

Nie, Ling; Zhou, Xiaoli; Peng, Lijun; Fu, Yao; Cheng, Yuqing; Huang, Qin

doi:10.5114/pjp.2018.81696

Cited by 14 publications

(20 citation statements)

References 44 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…from Japan [9,10]. An evaluation of the sarcomatous component showed that sarcomas in 8 out of 76 cases contained at least 2 ectopic component types, and 2 cases contained 3 ectopic component types [3]. In the present case, we observed a unique histology, including more independently differentiated regions than in those reported in the literature.…”

Section: Reports Of Cases That Include An Afp-producing Gastric Carcisupporting

confidence: 51%

“…In general, for the histological findings of gastric carcinosarcoma, the carcinomatous and sarcomatous components are predominantly adenocarcinomatous and undifferentiated sarcoma, respectively. Of the 76 cases of gastric carcinosarcoma found in a literature review by Nie et al, 4 were adenosquamous carcinomas, and 7 were neuroendocrine carcinomas [3].…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Early-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence: a case report

Shioya

Kurose²,

Mizutani³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Carcinosarcoma is a rare neoplasm with a poor prognosis that is most often discovered at an advanced stage; a gastric carcinosarcoma is even rarer than carcinosarcomas originating in other organs, such as the uterus. We report our experience with an early-stage multi-differentiated gastric carcinosarcoma. Case presentation A 68-year-old male patient presented with anemia, and his fecal occult blood test was positive. An endoscopic examination was conducted which revealed a hemorrhagic, irregular, protruding lesion in the stomach. The lesion was diagnosed as an adenocarcinoma by histopathological examination of the biopsy specimen, and a segmental gastrectomy was performed. A 41 × 29 × 18 mm 3 protruding lesion was observed in the resection specimen, and histologically confirmed to be a gastric carcinosarcoma with mixed adenocarcinomatous and sarcomatous composition. Tumor invasion was limited to the submucosa. Besides the adenocarcinomatous portion, neuroendocrine differentiation and AFP-positive gastric carcinoma were present in the carcinomatous portion of the tumor; in the sarcomatous portion, chondrosarcomatous, leiomyosarcomatous, and rhabdomyosarcomatous components were observed in addition to the undifferentiated sarcomatous component. Furthermore, the tumor included SALL4-positive germ cell-like cells. Despite early-stage detection, the cancer recurred locally 14 months after tumor resection, which necessitated a total gastrectomy. At the 2-month follow-up after the total gastrectomy, the patient was alive. This patient had developed an esophageal squamous cell carcinoma and primary lung adenosquamous carcinoma, both of which were resected. Conclusions Few cases of early-stage gastric carcinosarcoma have been reported, but there are no reports of recurrence to date. Local recurrence as in this patient, and even in early-stage cases, requires cautious surveillance to check for post-resection recurrence and metastasis. The etiopathogenesis of carcinosarcoma has not yet been elucidated; however, in the present case, despite the tumor’s relatively small size, it exhibited various types of differentiation in both the carcinomatous and sarcomatous components and a proliferative germ cell-like portion, which suggests that the monoclonal origin hypothesis may be a valid theory for the carcinosarcoma.

show abstract

Section: Reports Of Cases That Include An Afp-producing Gastric Carcisupporting

confidence: 51%

Section: Discussionmentioning

confidence: 96%

Early-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence: a case report

Shioya

Kurose²,

Mizutani³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In general, for the histological ndings of gastric carcinosarcoma, the carcinomatous and sarcomatous components are predominantly adenocarcinomatous and undifferentiated sarcoma, respectively. Of the 76 cases of gastric carcinosarcoma found in a literature review by Nie et al, 4 were adenosquamous carcinomas, and 7 were neuroendocrine carcinomas [3]. Reports of cases that include an AFP-producing gastric carcinoma component are limited to 2 cases from Japan [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…The resected gastric tumor was subjected to histopathological examination. Macroscopically, the gastrectomy specimen had a protruding lesion measuring 41 × 29 × 18 mm 3 (Fig. 1b).…”

Section: Case Presentationmentioning

confidence: 99%

“…Typical sites of carcinosarcoma include the uterus, ovaries, breasts, esophagus, thyroid, lungs, larynx, and urinary tract [1,2]. However, only a few cases of primary gastric carcinosarcoma have been reported; to date, less than 100 cases have been reported since Queckenstadt's report in 1904 [3,4,5]. Kuroda et al reported a mean patient age of 62.5 years and male predominance (male: female ratio of 5:2.2) with regard to gastric carcinosarcoma.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Early-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence: a case report

Shioya

Kurose²,

Mizutani³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Carcinosarcoma is a rare neoplasm with a poor prognosis that is most often discovered at an advanced stage; a gastric carcinosarcoma is even rarer than carcinosarcomas originating in other organs, such as the uterus. We report our experience with an early-stage multi-differentiated gastric carcinosarcoma.Case presentation A 68-year-old male patient presented with anemia, and his fecal occult blood test was positive. An endoscopic examination was conducted which revealed a hemorrhagic, irregular, protruding lesion in the stomach. The lesion was diagnosed as an adenocarcinoma by histopathological examination of the biopsy specimen, and a segmental gastrectomy was performed. A 41 × 29 × 18 mm3 protruding lesion was observed in the resection specimen, and histologically confirmed to be a gastric carcinosarcoma with mixed adenocarcinomatous and sarcomatous composition. Tumor invasion was limited to the submucosa. Besides the adenocarcinomatous portion, neuroendocrine differentiation and AFP-positive gastric carcinoma were present in the carcinomatous portion of the tumor; in the sarcomatous portion, chondrosarcomatous, leiomyosarcomatous, and rhabdomyosarcomatous components were observed in addition to the undifferentiated sarcomatous component. Furthermore, the tumor included SALL4-positive germ cell-like cells. Despite early-stage detection, the cancer recurred locally 14 months after tumor resection, which necessitated a total gastrectomy. At the 2-month follow-up after the total gastrectomy, the patient was alive. This patient had developed an esophageal squamous cell carcinoma and primary lung adenosquamous carcinoma, both of which were resected. Conclusions Few cases of early-stage gastric carcinosarcoma have been reported, but there are no reports of recurrence to date. Local recurrence as in this patient, and even in early-stage cases, requires cautious surveillance to check for post-resection recurrence and metastasis. The etiopathogenesis of carcinosarcoma has not yet been elucidated; however, in the present case, despite the tumor’s relatively small size, it exhibited various types of differentiation in both the carcinomatous and sarcomatous components and a proliferative germ cell-like portion, which suggests that the monoclonal origin hypothesis may be a valid theory for the carcinosarcoma.

show abstract

Carcinosarcoma of the stomach: four cases that expand the morphologic spectrum of gastric cancer with a primitive phenotype

Yamazawa

Ushiku

2022

Virchows Arch

View full text Add to dashboard Cite

Histological heterogeneity and distributional difference of gastric carcinosarcoma: report of 4 cases and literature review

Cited by 14 publications

References 44 publications

Early-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence: a case report

Early-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence: a case report

Early-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence: a case report

Carcinosarcoma of the stomach: four cases that expand the morphologic spectrum of gastric cancer with a primitive phenotype

Contact Info

Product

Resources

About