Histological grading and staging of chronic hepatitis

Ishak, Kamal G.; Baptista, António M.; Bianchi, Leonardo; Callea, Francesco; Groote, J. De; Gudat, F; Denk, Helmut; Desmet, Valeer; Korb, G; Macsween, R. N. M.; Phillips, M. James; Portmann, B; Poulsen, Hemming; Scheuer, Peter J.; Schmid, Martin; Thaler, H

doi:10.1016/0168-8278(95)80226-6

Cited by 4,485 publications

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“…Several other observations have been made concerning the importance of resistin in chronic HCV infection. Tsochatzis and colleagues found an inverse association between resistin levels and the severity of fibrosis (according to Ishak) in chronic viral hepatitis; and a nearly significant trend towards higher resistin levels in patients with HCV genotype-3 compared to other genotypes [24,46]. Tiftikci et al confirmed the finding of higher resistin levels in HCV patients with limited fibrosis (METAVIR scoring system), but found no association to HCV genotype [25,47].…”

Section: Discussionmentioning

confidence: 94%

High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation

et al. 2012

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The presence of autoantibodies against C-reactive protein (anti-CRP) has been reported in association with autoimmunity and histopathology in chronic hepatitis C virus (HCV) infection. Resistin could play a role in the pathogenesis of hepatitis, although results on HCV infection are ambiguous. Here we retrospectively analyzed anti-CRP and resistin levels in the sera of 38 untreated and well-characterized HCV patients at the time of their first liver biopsy. HCV activity and general health were assessed by a physician at least yearly until follow-up ended. Anti-CRP and resistin were also measured in patients with autoimmune hepatitis (AIH) and nonalcoholic fatty liver disease (NAFLD). Anti-CRP antibodies were registered in all HCV patients, whereas only a few AIH (11%) and NAFLD (12%) sera were positive. Anti-CRP levels were related to histopathological severity and were highest in patients with cirrhosis at baseline. Resistin levels were similar in HCV, AIH, and NAFLD patients, but high levels of resistin were associated with early mortality in HCV patients. Neither anti-CRP nor resistin predicted a response to interferon-based therapy or cirrhosis development or was associated with liver-related mortality. We conclude that anti-CRP antibodies are frequently observed in chronic HCV infection and could be a useful marker of advanced fibrosis and portal inflammation.Funding Agencies|Swedish Society for Medical Research||Professor Nanna Svartz Foundation||King Gustaf V 80-Year Foundation||Sweden-America Foundation||County Council of Ostergotland||Clas Groschinsky||byggmastare Olle Engkvist||apotekare Hedberg|

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Section: Discussionmentioning

confidence: 94%

High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation

et al. 2012

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“…7, plotted as a function of their spectroscopically measured HLC. Simulated relationships between T 1 and HLC are also included for three different levels of liver fibrosis, characterized by the Ishak score 31. MOLLI T 1 values at 0% HLC for the three curves were taken from Banerjee et al, as shown in their fig.…”

Section: Resultsmentioning

confidence: 99%

Influence of fat on liver T₁ measurements using modified Look–Locker inversion recovery (MOLLI) methods at 3T

Mózes

Tunnicliffe

Pavlides

et al. 2016

Magnetic Resonance Imaging

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PurposeTo characterize the effect of fat on modified Look–Locker inversion recovery (MOLLI) T 1 maps of the liver. The balanced steady‐state free precession (bSSFP) sequence causes water and fat signals to have opposite phase when repetition time (TR) = 2.3 msec at 3T. In voxels that contain both fat and water, the MOLLI T 1 measurement is influenced by the choice of TR.Materials and MethodsMOLLI T 1 measurements of the liver were simulated using the Bloch equations while varying the hepatic lipid content (HLC). Phantom scans were performed on margarine phantoms, using both MOLLI and spin echo inversion recovery sequences. MOLLI T 1 at 3T and HLC were determined in patients (n = 8) before and after bariatric surgery.ResultsAt 3T, with HLC in the 0–35% range, higher fat fraction values lead to longer MOLLI T 1 values when TR = 2.3 msec. Patients were found to have higher MOLLI T 1 at elevated HLC (T 1 = 929 ± 97 msec) than at low HLC (T 1 = 870 ± 44 msec).ConclusionAt 3T, MOLLI T 1 values are affected by HLC, substantially changing MOLLI T 1 in a clinically relevant range of fat content. J. Magn. Reson. Imaging 2016;44:105–111.

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“…All liver biopsies were examined by an experienced histopathologist and lesions were graded (necroinflammation) and staged (fibrosis) according to the histological activity index (HAI). [19] Steatosis was defined and graded according to Brunt and colleagues. [20] Liver sections were stained with Hematoxylin and Eosin (H and E) and with special stains, namely reticulin (for reticular fibers) and periodic acid-Schiff (PAS) (for glycogenated nuclei) before being examined.…”

Section: Methodsmentioning

confidence: 99%

Insulin resistance, steatosis, and fibrosis in Egyptian patients with chronic Hepatitis C virus infection

Ahmed

Hassan

Abd‐Elsayed

et al. 2011

Saudi J Gastroenterol

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Background/Aim:Both nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C virus (HCV) infection are common in Egypt, and their coexistence is expected. There is controversy regarding the influence of NAFLD on chronic HCV disease progression. This study evaluates the effect of NAFLD on the severity of chronic hepatitis C (CHC) (necroinflammation and fibrosis) and assesses the relative contribution of insulin resistance syndrome to the occurrence of NAFLD in patients with chronic HCV infection.Patients and Methods:Untreated consecutive adults with chronic HCV infection admitted for liver biopsy were included in this study. Before liver biopsy, a questionnaire for risk factors was completed prospectively, and a blood sample was obtained for laboratory analysis.Results:Our study included 92 male patients. Their mean ± SD age and aspartate aminotransferase (AST) level were 42 ± 7.7 years (range 20-56) and 68 ± 41.7 U/L (range 16-214), respectively. The mean insulin level and insulin resistance index were 15.6 ± 18.3 mIU/mL (range 5.1-137.4) and 5.9 ± 15.2 (range 0.9-136.2), respectively. Fifty four percent of patients had steatosis and 65% had fibrosis. In multivariate analyses, steatosis was associated with insulin resistance and fibrosis was associated with high AST level, age ≥40 years, and steatosis.Conclusions:Steatosis is a histopathologic feature in >50% of patients with chronic HCV infection. Insulin resistance has an important role in the pathogenesis of steatosis, which represents a significant determinant of fibrosis together with high serum AST level and older age.

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Histological grading and staging of chronic hepatitis

Cited by 4,485 publications

References 8 publications

High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation

High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation

Influence of fat on liver T₁ measurements using modified Look–Locker inversion recovery (MOLLI) methods at 3T

Insulin resistance, steatosis, and fibrosis in Egyptian patients with chronic Hepatitis C virus infection

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Histological grading and staging of chronic hepatitis

Cited by 4,485 publications

References 8 publications

High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation

High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation

Influence of fat on liver T1 measurements using modified Look–Locker inversion recovery (MOLLI) methods at 3T

Insulin resistance, steatosis, and fibrosis in Egyptian patients with chronic Hepatitis C virus infection

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Influence of fat on liver T₁ measurements using modified Look–Locker inversion recovery (MOLLI) methods at 3T