Histological findings in the Paterson-Kelly syndrome

Abstract

SYNOPSIS Forty-one specimens taken from lesions in the post-cricoid region of patients with the Paterson-Kelly syndrome have been examined. Most Forty-one specimens were obtained from post-cricoid lesions in 39 patients. The specimens were mostly small and contained epithelium and subepithelial elements superficial to the main muscular layers. In five instances, the biopsies consisted of epithelium alone. Deeper tissues were present in specimens from four necropsies, but in only one biopsy.Paraffin sections were stained by haematoxylin and eosin, periodic acid-Schiff (P.A.S.) for the detection of glycogen with control sections pretreated with salivary diastase at 37°C. for non-glycogen polysaccharides; Perls's reaction to identify haemosiderin, and van Gieson's stain for collagen. In post-mortem tissue, Luxolvan Gieson's stain was also used to demonstrate nerve and muscle changes.Arrangement of the material into the following three groups facilitates interpretation of the histological appearances in the different lesions.WEBS Twenty-six specimens were derived from postcricoid webs. The 22 women and two men were aged 29 to 74 years (mean 53 9 years) and their mean duration of dysphagia was 9 0 years. Nineteen patients had never required dilatation; five had had one previous dilatation, and the group includes as separate specimens tissues taken on the first occasion in two of these. All but four patients were anaemic either at the time of biopsy or before then. STRICTURES There were nine women with upper oeso-

Reconstruction of the cervical esophagus using a free transverse colonic graft: Report of a case with upper esophageal web and carcinoma

“…Dysphagia had been present for 30 years, but determination of whether the web was congenital is difficult. The pathophysiology of plication in patients diagnosed with esophageal web reportedly comprises the growth of connective tissues in the lamina propria, infiltration of lymphocytes, 6 and in this case the web surface was covered with mucosal carcinoma. Although the tumor in the posterior cervical esophageal wall was regional squamous cell carcinoma, it is difficult to determine whether this tumor originated from the web, or whether an esophageal carcinoma infiltrating into the mucosal layer de novo resulted in formation of the web.…”

Oesophagitis dissecans superficialis complicating repeated rigid oesophagoscopy and dilatation

“…It is known that the histology of a postcricoid web is essentially that of a fold of normal oesophageal epithelium with some underlying loose connective tissue. 11 We contemplate that the web had become less prominent after its epithelial layer sloughed off along with the oesophageal cast.…”

Congenital Esophageal Stenosis: A Case Report and Review of the Literature

“…Symptomatic webs are more often found in females and if associated with iron-deficiency anemia, koilonychias, and glossitis can be associated with Plummer-Vinson or Patterson-Kelly syndromes (2,6). Webs usually consist of mucosa and submucosa and involve a connective tissue band covered with normal epithelium (3). The exact etiology is not known, but it has been suggested that they occur as a consequence of incomplete vacuolization of esophageal columnar epithelium during embryological development (14).…”