Histological findings in skeletal muscle of SARS-CoV2 infected patient

Mageriu, Vlad; Zurac, Sabina; Bastian, Alexandra; Stăniceanu, Florica; Manole, Emilia

doi:10.1080/15321819.2020.1863819

Cited by 6 publications

(9 citation statements)

References 15 publications

(14 reference statements)

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“…The skeletal muscle displayed damage by the viral cytopathic effect and by elevated cytokines [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

“…Others like dementia [ 23 ], Immunosuppressive medication [ 24 ], Liver steatosis, and cerebral small vessel disease [ 31 ]. Gastric carcinoma, hepatocellular carcinoma, basal cell carcinoma [ 34 ] Graft-versus-host disease following cancer [ 44 ] Bone marrow transplantation (BMT) [ 44 ], and HIV positive status [ 45 ] Lungs Gross changes observed Thrombosis and embolic phenomenon in small- and large- sized arteries [ 4 – 6 , 9 , 14 , 17 , 18 , 24 , 36 , 40 , 42 , 43 , 45 , 46 , 48 , 51 , 52 , 59 , 60 , 66 , 68 , 70 , 76 , 80 , 83 , 86 , 88 , 92 – 94 , 97 , 104 , 105 ] Pulmonary infarction, haemorrhagic infarcts [ 6 , 27 , 78 , 80 , 83 ]. Fibrosis [ 5 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…Thrombosis and embolic phenomenon in small- and large- sized arteries [ 4 – 6 , 9 , 14 , 17 , 18 , 24 , 36 , 40 , 42 , 43 , 45 , 46 , 48 , 51 , 52 , 59 , 60 , 66 , 68 , 70 , 76 , 80 , 83 , 86 , 88 , 92 – 94 , 97 , 104 , 105 ]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Findings and inferences from full autopsies, minimally invasive autopsies and biopsy studies in patients who died as a result of COVID19 — A systematic review

Raviraj¹,

Shobhana²

2022

Forensic Sci Med Pathol

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Many articles on COVID19 deaths have been published since the pandemic has occurred. On reviewing the articles published until June 2021, the findings were very heterogeneous. Adding to the existing knowledge, there were also some unique observations made in the pathogenesis of COVID19. This review was done to determine the findings obtained and inferences drawn from various studies published globally among patients who died due to COVID19. PRISMA guidelines were used to conduct this systematic review. A search of databases like PubMed, ScienceDirect and Epistemonikos was done. The articles focusing on postmortem sample studies involving full autopsies, minimally invasive autopsies and tissue biopsy studies were screened and searched. The studies included were all the case reports, case series, narrative reviews and systematic reviews obtained in full text and in the English language containing study information, and samples obtained postmortem. The information obtained was tabulated using Microsoft excel sheets. The duplicates were removed at the beginning of the tabulation. Zotero referencing software was used for article sorting and citation and bibliography. Two authors independently reviewed the articles throughout the process to prevent bias. Adding to the heterogeneity of COVID19, the concept of lethality in preexisting disease conditions, the occurrence of secondary bacterial and fungal infections, and other pathogenetic mechanisms uniquely encountered are to be considered in treating the patients. Also, the presence of SARS-CoV-2 postmortem is established and should be considered a hazard.

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“…The skeletal muscle displayed damage by the viral cytopathic effect and by elevated cytokines [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Findings and inferences from full autopsies, minimally invasive autopsies and biopsy studies in patients who died as a result of COVID19 — A systematic review

Raviraj¹,

Shobhana²

2022

Forensic Sci Med Pathol

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“…Cabañes-Martínez et al also confirmed, through muscle biopsy ( quadriceps femoris and tibialis anterior ), a diagnosis of critical myopathy in 12 patients with severe COVID-19; however they related this condition to the long stay in ICU ( Cabañes-Martínez et al, 2020 ). Additionally, two studies carry out histological assays in muscle tissues ( rectus abdominis and psoas ) of patients, who died from severe COVID-19 ( Mageriu et al, 2020 ; Suh et al, 2021 ). The authors found signs of necrotizing myopathy, myositis and fiber atrophy in the analysed samples, which, according to them, can be a result of the pro-inflammatory cytokine release that occurs during SARS-CoV-2 infection ( Mageriu et al, 2020 ; Suh et al, 2021 ).…”

Section: The Lack Of Musculoskeletal Data Related To Mild To Moderate...mentioning

confidence: 99%

“…Additionally, two studies carry out histological assays in muscle tissues ( rectus abdominis and psoas ) of patients, who died from severe COVID-19 ( Mageriu et al, 2020 ; Suh et al, 2021 ). The authors found signs of necrotizing myopathy, myositis and fiber atrophy in the analysed samples, which, according to them, can be a result of the pro-inflammatory cytokine release that occurs during SARS-CoV-2 infection ( Mageriu et al, 2020 ; Suh et al, 2021 ). Lastly, a case report described histopathologic alterations (e.g., microthrombi, microhemorrhages, fiber degeneration and necrosis) in the skeletal muscle of a patient who died from COVID-19; however, they associated the observed changes to vascular damage and endothelial injury than to a direct myocite viral infection ( Hooper et al, 2021 ).…”

Section: The Lack Of Musculoskeletal Data Related To Mild To Moderate...mentioning

confidence: 99%

The Musculoskeletal Involvement After Mild to Moderate COVID-19 Infection

et al. 2022

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COVID-19, a disease caused by the novel coronavirus SARS-CoV-2, has been drastically affecting the daily lives of millions of people. COVID-19 is described as a multiorgan disease that affects not only the respiratory tract of infected individuals, but it has considerable effects on the musculoskeletal system, causing excessive fatigue, myalgia, arthralgia, muscle weakness and skeletal muscle damage. These symptoms can persist for months, decreasing the quality of life of numerous individuals. Curiously, most studies in the scientific literature focus on patients who were hospitalized due to SARS-CoV-2 infection and little is known about the mechanism of action of COVID-19 on skeletal muscles, especially of individuals who had the mild to moderate forms of the disease (non-hospitalized patients). In this review, we focus on the current knowledge about the musculoskeletal system in COVID-19, highlighting the lack of researches investigating the mild to moderate cases of infection and pointing out why it is essential to care for these patients. Also, we will comment about the need of more experimental data to assess the musculoskeletal manifestations on COVID-19-positive individuals.

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Muscle abnormalities worsen after post-exertional malaise in long COVID

Appelman,

Charlton,

Goulding

et al. 2024

Nat Commun

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A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is post-exertional malaise, which is associated with a worsening of fatigue- and pain-related symptoms after acute mental or physical exercise, but its underlying pathophysiology is unclear. With this longitudinal case-control study (NCT05225688), we provide new insights into the pathophysiology of post-exertional malaise in patients with long COVID. We show that skeletal muscle structure is associated with a lower exercise capacity in patients, and local and systemic metabolic disturbances, severe exercise-induced myopathy and tissue infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID worsen after induction of post-exertional malaise. This study highlights novel pathways that help to understand the pathophysiology of post-exertional malaise in patients suffering from long COVID and other post-infectious diseases.

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Histological findings in skeletal muscle of SARS-CoV2 infected patient

Cited by 6 publications

References 15 publications

Findings and inferences from full autopsies, minimally invasive autopsies and biopsy studies in patients who died as a result of COVID19 — A systematic review

Findings and inferences from full autopsies, minimally invasive autopsies and biopsy studies in patients who died as a result of COVID19 — A systematic review

The Musculoskeletal Involvement After Mild to Moderate COVID-19 Infection

Muscle abnormalities worsen after post-exertional malaise in long COVID

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